Question 1

In order for an individual to express Leb antigen on their red blood cells, they must have inherited which gene?

Accepted Answer

A)  Le 
B)  Se 
C)  H 
D)  All of the above 
A)  Le 
B)  Se 
C)  H 
D)  All of the above

Question 2

What amino acid is specific for S antigen?

Accepted Answer

A)  Glycine 
B)  Threonine 
C)  Methionine 
D)  Aspartic acid 
A)  Glycine 
B)  Threonine 
C)  Methionine 
D)  Aspartic acid

Question 3

Individuals who are Le(a-b-) and can develop Lewis antibodies without exposure to Lewis antigens are called:

Accepted Answer

A)  immune mediated. 
B)  biphasic. 
C)  naturally occurring. 
D)  autoantibodies. 
A)  immune mediated. 
B)  biphasic. 
C)  naturally occurring. 
D)  autoantibodies.

Question 4

An individual from Bombay who has inherited the Le gene will have a phenotype of:

Accepted Answer

A)  Le(a-b-). 
B)  Le(a+b+). 
C)  Le(a+b-). 
D)  Le(a-b+). 
A)  Le(a-b-). 
B)  Le(a+b+). 
C)  Le(a+b-). 
D)  Le(a-b+).

Question 5

All of the following characteristics regarding the Kell antigen are true except:

Accepted Answer

A)  it is well-developed at birth. 
B)  it exhibits dosage. 
C)  it is destroyed by ficin treatment. 
D)  it is strongly immunogenic. 
A)  it is well-developed at birth. 
B)  it exhibits dosage. 
C)  it is destroyed by ficin treatment. 
D)  it is strongly immunogenic.

Question 6

Which of the following techniques/reagents may be useful in increasing the reactivity of anti-M?

Accepted Answer

A)  Papain pretreated cells 
B)  Anticomplement AHG reagents 
C)  Acidified serum techniques 
D)  Heterozygous MN Cells 
A)  Papain pretreated cells 
B)  Anticomplement AHG reagents 
C)  Acidified serum techniques 
D)  Heterozygous MN Cells

Question 7

Antibodies to the blood groups below exhibit dosage EXCEPT:

Accepted Answer

A)  Duffy 
B)  Kell 
C)  Kidd 
D)  MNS 
A)  Duffy 
B)  Kell 
C)  Kidd 
D)  MNS

Question 8

Persons who inherit the In(Lu) gene will exhibit:

Accepted Answer

A)  Jk(a-b+) red blood cells that can elute anti-Jk3. 
B)  Jk(a+b-) red blood cells that can elute anti-Jka. 
C)  Jk(a+b-) red blood cells that can absorb anti-Jk3. 
D)  Jk(a-b-) red blood cells that can absorb anti-Jka. 
A)  Jk(a-b+) red blood cells that can elute anti-Jk3. 
B)  Jk(a+b-) red blood cells that can elute anti-Jka. 
C)  Jk(a+b-) red blood cells that can absorb anti-Jk3. 
D)  Jk(a-b-) red blood cells that can absorb anti-Jka.

Question 9

Which population has the greatest frequency of the Fy(a-b-) phenotype?

Accepted Answer

A)  White 
B)  Black 
C)  Asian 
D)  Native American 
A)  White 
B)  Black 
C)  Asian 
D)  Native American

Question 10

RBCs from an adult are suspected of having a rare i-antigen. Which of the follow reactions is expected with these cells?

Accepted Answer

A)  Anti-I strong; Anti-I weak; Anti-IT- weak 
B)  Anti-I weak; Anti-I strong; Anti-IT- strong 
C)  Anti-I weak; Anti-I strong; Anti-IT- weak 
D)  Anti-I weak; Anti-I weak; Anti-IT- strong 
A)  Anti-I strong; Anti-I weak; Anti-IT- weak 
B)  Anti-I weak; Anti-I strong; Anti-IT- strong 
C)  Anti-I weak; Anti-I strong; Anti-IT- weak 
D)  Anti-I weak; Anti-I weak; Anti-IT- strong

Question 11

How does anti-Lea differ from anti-Leb?

Accepted Answer

A)  Only anti-Lea will be produced in Le(a-b-) individuals. 
B)  Anti-Lea can bind complement more efficiently. 
C)  Anti-Leb is an IgG antibody. 
D)  Anti-Lea is an IgM antibody. 
A)  Only anti-Lea will be produced in Le(a-b-) individuals. 
B)  Anti-Lea can bind complement more efficiently. 
C)  Anti-Leb is an IgG antibody. 
D)  Anti-Lea is an IgM antibody.

Question 12

Duffy antigens are destroyed by:

Accepted Answer

A)  AET. 
B)  ficin. 
C)  neuraminidase. 
D)  neuraminidase and AET. 
A)  AET. 
B)  ficin. 
C)  neuraminidase. 
D)  neuraminidase and AET.

Question 13

Which of the follow lists of phenotypes is written correctly?

Accepted Answer

A)  S+s+, K-; Fy(a+b-) 
B)  S+s+ / K- / Fy(a+b-) 
C)  S+s+; K-; Fy(a+b-) 
D)  S+s+: K-: Fy(a+b-) 
A)  S+s+, K-; Fy(a+b-) 
B)  S+s+ / K- / Fy(a+b-) 
C)  S+s+; K-; Fy(a+b-) 
D)  S+s+: K-: Fy(a+b-)

Question 14

What portion of GPA reacts with anti- EnaFR?

Accepted Answer

A)  Phenylalanine resistant 
B)  Phenylalanine sensitive 
C)  Ficin resistant 
D)  Ficin sensitive 
A)  Phenylalanine resistant 
B)  Phenylalanine sensitive 
C)  Ficin resistant 
D)  Ficin sensitive

Question 15

How can pathologic anti-I be differentiated from benign anti-I?

Accepted Answer

A)  Immunoglobulin class 
B)  Binding of complement 
C)  Broad thermal range of reactivity 
D)  All of the above 
A)  Immunoglobulin class 
B)  Binding of complement 
C)  Broad thermal range of reactivity 
D)  All of the above

Question 16

What is found in secretions of Le(a-b-) individuals?

Accepted Answer

A)  Lea 
B)  Leb 
C)  Both a and b 
D)  None of the above 
A)  Lea 
B)  Leb 
C)  Both a and b 
D)  None of the above

Question 17

What is the definition of a blood group system?

Accepted Answer

A)  A group of antibodies produced by alleles at a single gene locus 
B)  A group of antigens produced by alleles at a single gene locus 
C)  A group of antibodies produced by alleles at multiple genetic loci 
D)  A group of antigens produced by alleles at multiple genetic loci 
A)  A group of antibodies produced by alleles at a single gene locus 
B)  A group of antigens produced by alleles at a single gene locus 
C)  A group of antibodies produced by alleles at multiple genetic loci 
D)  A group of antigens produced by alleles at multiple genetic loci

Question 18

All of the following are characteristic of anti-P1 except:

Accepted Answer

A)  the antibody is IgM. 
B)  the antibody reacts strongly at room temperature. 
C)  the antibody is not neutralized by soluble P1 substance. 
D)  the antibody may be detected in AHG phase of antiglobulin test if polyspecific antiserum is used. 
A)  the antibody is IgM. 
B)  the antibody reacts strongly at room temperature. 
C)  the antibody is not neutralized by soluble P1 substance. 
D)  the antibody may be detected in AHG phase of antiglobulin test if polyspecific antiserum is used.

Question 19

What does the U in U antigen stand for?

Accepted Answer

A)  unusual 
B)  universal 
C)  uniform 
D)  unique 
A)  unusual 
B)  universal 
C)  uniform 
D)  unique

Question 20

What is the ISBT designation for the Ii blood groups?

Accepted Answer

A)  200 
B)  207 
C)  300 
D)  310 
A)  200 
B)  207 
C)  300 
D)  310

Exam 8: Blood Group Terminology and Common Blood Groups

In order for an individual to express Leb antigen on their red blood cells, they must have inherited which gene?

What amino acid is specific for S antigen?

Individuals who are Le(a-b-) and can develop Lewis antibodies without exposure to Lewis antigens are called:

An individual from Bombay who has inherited the Le gene will have a phenotype of:

All of the following characteristics regarding the Kell antigen are true except:

Which of the following techniques/reagents may be useful in increasing the reactivity of anti-M?

Antibodies to the blood groups below exhibit dosage EXCEPT:

Persons who inherit the In(Lu) gene will exhibit:

Which population has the greatest frequency of the Fy(a-b-) phenotype?

RBCs from an adult are suspected of having a rare i-antigen. Which of the follow reactions is expected with these cells?

How does anti-Lea differ from anti-Leb?

Duffy antigens are destroyed by:

Which of the follow lists of phenotypes is written correctly?

What portion of GPA reacts with anti- EnaFR?

How can pathologic anti-I be differentiated from benign anti-I?

What is found in secretions of Le(a-b-) individuals?

What is the definition of a blood group system?

All of the following are characteristic of anti-P1 except:

What does the U in U antigen stand for?

What is the ISBT designation for the Ii blood groups?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters

In order for an individual to express Le^b antigen on their red blood cells, they must have inherited which gene?

How does anti-Le^a differ from anti-Le^b?

What portion of GPA reacts with anti- En^aFR?

All of the following are characteristic of anti-P₁ except: