Question 1

Which of the following statements about dimethyl sulfoxide (DMSO) is true?

Accepted Answer

A)  DMSO is nontoxic. 
B)  DMSO prevents damage to HPCs during the freezing process. 
C)  DMSO destroys non-HPC white blood cells. 
D)  All of the above 
A)  DMSO is nontoxic. 
B)  DMSO prevents damage to HPCs during the freezing process. 
C)  DMSO destroys non-HPC white blood cells. 
D)  All of the above B

Question 2

What is the first cell in the formation of all blood cells?

Accepted Answer

A)  Hematopoietic stem cell 
B)  Hematopoietic progenitor cell 
C)  Multipotent progenitor cell 
D)  Pluripotent progenitor cell 
A)  Hematopoietic stem cell 
B)  Hematopoietic progenitor cell 
C)  Multipotent progenitor cell 
D)  Pluripotent progenitor cell A

Question 3

Which symptom is NOT likely to have been caused by chronic GVHD?

Accepted Answer

A)  Dry mouth 
B)  Gastroenteritis 
C)  Joint contractures 
D)  Lung damage 
A)  Dry mouth 
B)  Gastroenteritis 
C)  Joint contractures 
D)  Lung damage B

Question 4

Donor plasma antibodies can bind to and cause destruction of recipient RBCs in which ABO incompatibility?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these

Question 5

The use of one's own HPCs for transplantation is referred to as:

Accepted Answer

A)  Allogeneic 
B)  Autologous 
C)  Syngeneic 
D)  None of these 
A)  Allogeneic 
B)  Autologous 
C)  Syngeneic 
D)  None of these

Question 6

Group O hematopoietic progenitor cell products are best used for which type of mismatch situation?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  All of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  All of these

Question 7

For a recipients with a major mismatch, HPC products of which group are usually selected until the recipient antibodies that are incompatible with HPC product are no longer detected?

Accepted Answer

A)  O 
B)  A 
C)  B 
D)  AB 
A)  O 
B)  A 
C)  B 
D)  AB

Question 8

Nonmyeloablative conditioning means:

Accepted Answer

A)  intervention uses reduced amounts of chemotherapy and/or radiation. 
B)  without intervention the bone marrow would not recover without HPC transplantation. 
C)  without intervention immune function would not recover without HPC transplantation. 
D)  none of these. 
A)  intervention uses reduced amounts of chemotherapy and/or radiation. 
B)  without intervention the bone marrow would not recover without HPC transplantation. 
C)  without intervention immune function would not recover without HPC transplantation. 
D)  none of these.

Question 9

Laboratory tests performed on HPC products include the enumeration of all of these EXCEPT:

Accepted Answer

A)  Plasma cells 
B)  Progenitors 
C)  Viable cells 
D)  WBC percentages 
A)  Plasma cells 
B)  Progenitors 
C)  Viable cells 
D)  WBC percentages

Question 10

The final bacterial culture was positive for hematopoietic progenitor cell batch. What must be done with this batch?

Accepted Answer

A)  The batch must be discarded. 
B)  Broad spectrum antibiotics can be given to the patient and the batch infused. 
C)  Have a sensitivity done on the culture and administer the batch, as well as provide antibiotics to which the bacteria are sensitive to the patient. 
D)  The batch can be irradiated and then transfused. 
A)  The batch must be discarded. 
B)  Broad spectrum antibiotics can be given to the patient and the batch infused. 
C)  Have a sensitivity done on the culture and administer the batch, as well as provide antibiotics to which the bacteria are sensitive to the patient. 
D)  The batch can be irradiated and then transfused.

Question 11

Which of these infectious diseases is not included in screening tests for donors of allogeneic HPC products?

Accepted Answer

A)  cytomegalovirus (CMV) 
B)  human T-cell lymphotrophic virus (HTLV) 
C)  respiratory syncytial virus (RSV) 
D)  syphilis 
A)  cytomegalovirus (CMV) 
B)  human T-cell lymphotrophic virus (HTLV) 
C)  respiratory syncytial virus (RSV) 
D)  syphilis

Question 12

What percent of HPC transplants have a minor ABO incompatibility?

Accepted Answer

A)  1% to 5 % 
B)  6% to 14 % 
C)  15% to 19 % 
D)  20% to 25 % 
A)  1% to 5 % 
B)  6% to 14 % 
C)  15% to 19 % 
D)  20% to 25 %

Question 13

Which symptom is NOT likely to have been caused by acute GVHD?

Accepted Answer

A)  Gastroenteritis 
B)  Reduced mobility 
C)  Skin rash 
D)  Transaminitis 
A)  Gastroenteritis 
B)  Reduced mobility 
C)  Skin rash 
D)  Transaminitis

Question 14

Minor hemolysis of recipient RBCs due to passenger lymphocyte syndrome can be seen in which ABO incompatibility?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these

Question 15

HPC transplant recipients can be at risk for delayed red blood cell production in which ABO incompatibility?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  none of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  none of these

Question 16

What is the target collection goal for CD34 positive cells in an HPC products?

Accepted Answer

A)  CD34 enumeration 
B)  Complete blood count 
C)  White blood cell differential 
D)  All of these 
A)  CD34 enumeration 
B)  Complete blood count 
C)  White blood cell differential 
D)  All of these

Question 17

Donors of allogeneic HPC products have to be carefully screened for which of these?

Accepted Answer

A)  Sickle cell disease 
B)  Human leukocyte antigen (HL
A)  type 
C)  Congenital immune deficiencies 
D)  All of these 
A)  Sickle cell disease 
B)  Human leukocyte antigen (HL
A)  type 
C)  Congenital immune deficiencies 
D)  All of these

Question 18

Both autologous and allogeneic HPC transplant recipients are at an increased risk for which type of graft-versus-host disease?

Accepted Answer

A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  None of these 
A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  None of these

Question 19

For recipients with a bidirectional incompatibility, HPC products of which group are usually selected until the recipient antibodies that are incompatible with HPC product are no longer detected?

Accepted Answer

A)  O 
B)  A 
C)  B 
D)  AB 
A)  O 
B)  A 
C)  B 
D)  AB

Question 20

What percent of HPC transplants have major ABO incompatibility?

Accepted Answer

A)  1% to 5 % 
B)  6% to 14 % 
C)  15% to 19 % 
D)  20% to 25 % 
A)  1% to 5 % 
B)  6% to 14 % 
C)  15% to 19 % 
D)  20% to 25 %

Exam 19: Cellular Therapy in the Transplant Setting

Which of the following statements about dimethyl sulfoxide (DMSO) is true?

What is the first cell in the formation of all blood cells?

Which symptom is NOT likely to have been caused by chronic GVHD?

Donor plasma antibodies can bind to and cause destruction of recipient RBCs in which ABO incompatibility?

The use of one's own HPCs for transplantation is referred to as:

Group O hematopoietic progenitor cell products are best used for which type of mismatch situation?

For a recipients with a major mismatch, HPC products of which group are usually selected until the recipient antibodies that are incompatible with HPC product are no longer detected?

Nonmyeloablative conditioning means:

Laboratory tests performed on HPC products include the enumeration of all of these EXCEPT:

The final bacterial culture was positive for hematopoietic progenitor cell batch. What must be done with this batch?

Which of these infectious diseases is not included in screening tests for donors of allogeneic HPC products?

What percent of HPC transplants have a minor ABO incompatibility?

Which symptom is NOT likely to have been caused by acute GVHD?

Minor hemolysis of recipient RBCs due to passenger lymphocyte syndrome can be seen in which ABO incompatibility?

HPC transplant recipients can be at risk for delayed red blood cell production in which ABO incompatibility?

What is the target collection goal for CD34 positive cells in an HPC products?

Donors of allogeneic HPC products have to be carefully screened for which of these?

Both autologous and allogeneic HPC transplant recipients are at an increased risk for which type of graft-versus-host disease?

For recipients with a bidirectional incompatibility, HPC products of which group are usually selected until the recipient antibodies that are incompatible with HPC product are no longer detected?

What percent of HPC transplants have major ABO incompatibility?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

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