Question 1

Why are donors deferred for 6 months following receipt of blood products?

Accepted Answer

A)  To permit adequate screening for transfusion-acquired viral infections 
B)  Because donation may cause recurrence of the condition that required transfusion 
C)  To allow clearance of all transfused cells in the donor 
D)  To allow donor recovery from the condition that required transfusion 
A)  To permit adequate screening for transfusion-acquired viral infections 
B)  Because donation may cause recurrence of the condition that required transfusion 
C)  To allow clearance of all transfused cells in the donor 
D)  To allow donor recovery from the condition that required transfusion A

Question 2

Pathogen reduction systems may not be effective against which agents?

Accepted Answer

A)  Prions 
B)  Low-titer viruses 
C)  Enveloped viruses 
D)  Bacteria without spores 
A)  Prions 
B)  Low-titer viruses 
C)  Enveloped viruses 
D)  Bacteria without spores A

Question 3

Which of the following patients would be at a greater risk for CMV infection?

Accepted Answer

A)  An autologous transplant recipient 
B)  A low-birth-weight infant transfused with CMV-negative blood 
C)  An allogenic bone marrow transplant recipient 
D)  None of the above 
A)  An autologous transplant recipient 
B)  A low-birth-weight infant transfused with CMV-negative blood 
C)  An allogenic bone marrow transplant recipient 
D)  None of the above C

Question 4

Which of the following findings is not part of the typical pattern of hepatitis A infection?

Accepted Answer

A)  Anti-HAV IgM antibodies 
B)  Anti-HAV IgG antibodies 
C)  Virus in stool 
D)  Elevated ALT 
A)  Anti-HAV IgM antibodies 
B)  Anti-HAV IgG antibodies 
C)  Virus in stool 
D)  Elevated ALT

Question 5

A person infected with HIV-1 is diagnosed with AIDS-related condition (ARC). What antibodies will be present in the patient's serum at this stage?

Accepted Answer

A)  Anti-p24 
B)  Anti-gp41 
C)  Anti-p26 
D)  Anti-p24 and anti-gp41 
A)  Anti-p24 
B)  Anti-gp41 
C)  Anti-p26 
D)  Anti-p24 and anti-gp41

Question 6

What is the source of hepatitis B immune globulin (HBIG)?

Accepted Answer

A)  Persons with a high titer of anti-HBc(IgG) 
B)  Persons with a high titer of anti-HBe 
C)  Persons with a high titer of anti-HBs 
D)  Persons with a high titer of anti-HBc(IgM) 
A)  Persons with a high titer of anti-HBc(IgG) 
B)  Persons with a high titer of anti-HBe 
C)  Persons with a high titer of anti-HBs 
D)  Persons with a high titer of anti-HBc(IgM)

Question 7

Which test can reveal an asymptomatic patient with TAH?

Accepted Answer

A)  BUN 
B)  AST 
C)  ALT 
D)  Amylase 
A)  BUN 
B)  AST 
C)  ALT 
D)  Amylase

Question 8

Which of the following is indicated when a recipient of blood or blood components develops a viral disease?

Accepted Answer

A)  Transfusion-reaction investigation 
B)  Donor look-back 
C)  Incident report 
D)  Type and screen 
A)  Transfusion-reaction investigation 
B)  Donor look-back 
C)  Incident report 
D)  Type and screen

Question 9

This disease can be transmitted through blood transfusion and is characterized by sponge-like lesions of the brain.

Accepted Answer

A)  Cytomegalovirus 
B)  Epstein-Barr virus 
C)  Creutzfeldt-Jakob disease 
D)  Chagas' disease 
A)  Cytomegalovirus 
B)  Epstein-Barr virus 
C)  Creutzfeldt-Jakob disease 
D)  Chagas' disease

Question 10

Which of the following viral infections poses a severe threat to chronically transfused individuals who carry the hepatitis B virus (HBV)?

Accepted Answer

A)  Superinfection by hepatitis C virus (HCV) 
B)  Infection with hepatitis G virus (HGV) 
C)  Superinfection by hepatitis D virus (HDV) 
D)  Non-A, non-B, non-C virus (NANBNC virus) 
A)  Superinfection by hepatitis C virus (HCV) 
B)  Infection with hepatitis G virus (HGV) 
C)  Superinfection by hepatitis D virus (HDV) 
D)  Non-A, non-B, non-C virus (NANBNC virus)

Question 11

A blood donor's serologic tests were reactive for HIV-1/2 antibodies. The test was repeated, and both were reactive. A Western blot confirmatory test was done and was negative. What is the protocol for this donor?

Accepted Answer

A)  Unit is discarded. 
B)  Health department is notified. 
C)  Unit is OK to use. 
D)  Donor is permanently deferred. 
A)  Unit is discarded. 
B)  Health department is notified. 
C)  Unit is OK to use. 
D)  Donor is permanently deferred.

Question 12

Which of the following parasites has not been associated with transmission via blood transfusion?

Accepted Answer

A)  Trypanosoma cruzi 
B)  Plasmodium spp. 
C)  Leishmania 
D)  None of the above 
A)  Trypanosoma cruzi 
B)  Plasmodium spp. 
C)  Leishmania 
D)  None of the above

Question 13

A single donor tested positive for HIV-1 via enzyme immunoassay screening techniques. The blood was retested and found to be nonreactive. What is the status of the donor whole blood unit?

Accepted Answer

A)  A confirmatory test should be performed. 
B)  Blood and components are okay for use. 
C)  The unit should be discarded. 
D)  The donor should be placed on the re-entry list. 
A)  A confirmatory test should be performed. 
B)  Blood and components are okay for use. 
C)  The unit should be discarded. 
D)  The donor should be placed on the re-entry list.

Question 14

Which test is now used in the processing of all source plasmas for pathogen inactivation verification?

Accepted Answer

A)  DAT 
B)  ELISA 
C)  HPLC 
D)  NAT 
A)  DAT 
B)  ELISA 
C)  HPLC 
D)  NAT

Question 15

The cytomegalovirus and Epstein-Barr virus belong to which family of viruses?

Accepted Answer

A)  Flaviviridae 
B)  Retroviridae 
C)  Herpesviridae 
D)  Picornaviridae 
A)  Flaviviridae 
B)  Retroviridae 
C)  Herpesviridae 
D)  Picornaviridae

Question 16

HBsAg is what part of the hepatitis B virus?

Accepted Answer

A)  Core protein 
B)  Coat protein 
C)  Dane particle 
D)  Capsid protein 
A)  Core protein 
B)  Coat protein 
C)  Dane particle 
D)  Capsid protein

Question 17

Which two infectious agents share the same vector?

Accepted Answer

A)  Rickettsia and Leishmania 
B)  Babesia and Borrelia 
C)  Borrelia and Plasmodium 
D)  Babesia and Trypanosoma 
A)  Rickettsia and Leishmania 
B)  Babesia and Borrelia 
C)  Borrelia and Plasmodium 
D)  Babesia and Trypanosoma

Question 18

What treatment is recommended for chronic liver disease due to hepatitis C virus infection?

Accepted Answer

A)  Gamma globulin 
B)  Prednisone 
C)  Alpha interferon 
D)  Gamma interferon 
A)  Gamma globulin 
B)  Prednisone 
C)  Alpha interferon 
D)  Gamma interferon

Question 19

HIV belongs to which family?

Accepted Answer

A)  Flaviviridae 
B)  Retroviridae 
C)  Hepadnaviridae 
D)  Picornaviridae 
A)  Flaviviridae 
B)  Retroviridae 
C)  Hepadnaviridae 
D)  Picornaviridae

Question 20

The hepatitis B virus belongs to which family?

Accepted Answer

A)  Picornaviridae 
B)  Hepadnaviridae 
C)  Flaviviridae 
D)  Retroviridae 
A)  Picornaviridae 
B)  Hepadnaviridae 
C)  Flaviviridae 
D)  Retroviridae

Exam 14: Transfusion-Transmitted Diseases

Why are donors deferred for 6 months following receipt of blood products?

Pathogen reduction systems may not be effective against which agents?

Which of the following patients would be at a greater risk for CMV infection?

Which of the following findings is not part of the typical pattern of hepatitis A infection?

A person infected with HIV-1 is diagnosed with AIDS-related condition (ARC). What antibodies will be present in the patient's serum at this stage?

What is the source of hepatitis B immune globulin (HBIG)?

Which test can reveal an asymptomatic patient with TAH?

Which of the following is indicated when a recipient of blood or blood components develops a viral disease?

This disease can be transmitted through blood transfusion and is characterized by sponge-like lesions of the brain.

Which of the following viral infections poses a severe threat to chronically transfused individuals who carry the hepatitis B virus (HBV)?

A blood donor's serologic tests were reactive for HIV-1/2 antibodies. The test was repeated, and both were reactive. A Western blot confirmatory test was done and was negative. What is the protocol for this donor?

Which of the following parasites has not been associated with transmission via blood transfusion?

A single donor tested positive for HIV-1 via enzyme immunoassay screening techniques. The blood was retested and found to be nonreactive. What is the status of the donor whole blood unit?

Which test is now used in the processing of all source plasmas for pathogen inactivation verification?

The cytomegalovirus and Epstein-Barr virus belong to which family of viruses?

HBsAg is what part of the hepatitis B virus?

Which two infectious agents share the same vector?

What treatment is recommended for chronic liver disease due to hepatitis C virus infection?

HIV belongs to which family?

The hepatitis B virus belongs to which family?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

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