Question 1

What does the "R" represent in Rh-Hr terminology?

Accepted Answer

A)  Absence of D antigen 
B)  Presence of D antigen 
C)  Presence of C antigen 
D)  Presence of e antigen 
A)  Absence of D antigen 
B)  Presence of D antigen 
C)  Presence of C antigen 
D)  Presence of e antigen B

Question 2

What is the basis of Rosenfield Rh terminology?

Accepted Answer

A)  Each gene produces one product or antigen. 
B)  The positive (+) or negative (-) sign demonstrates the presence or absence of antigen on a red blood cell. 
C)  The Rh gene produces at least three factors within an agglutinogen. 
D)  The Rh gene produces at least five factors within an agglutinogen. 
A)  Each gene produces one product or antigen. 
B)  The positive (+) or negative (-) sign demonstrates the presence or absence of antigen on a red blood cell. 
C)  The Rh gene produces at least three factors within an agglutinogen. 
D)  The Rh gene produces at least five factors within an agglutinogen. B

Question 3

Which of the following Rh phenotypes invites Cw antigen testing?

Accepted Answer

A)  C+c+ 
B)  E+e- 
C)  E-e+ 
D)  C+c- 
A)  C+c+ 
B)  E+e- 
C)  E-e+ 
D)  C+c- D

Question 4

Which gene combination is expressed in the greatest frequency in the black population?

Accepted Answer

A)  DCe 
B)  dce 
C)  Dce 
D)  DCE 
A)  DCe 
B)  dce 
C)  Dce 
D)  DCE

Question 5

The antigen ceCF is known as:

Accepted Answer

A)  Wrights antigen 
B)  Crawford antigen 
C)  D mosaic 
D)  V antigen 
A)  Wrights antigen 
B)  Crawford antigen 
C)  D mosaic 
D)  V antigen

Question 6

Which of the following statements regarding anti-LW is true?

Accepted Answer

A)  Anti-LW reacts poorly with cord cells. 
B)  Anti-LW reacts stronger with Rh-positive cells than with Rh-negative cells. 
C)  Rh-null individuals lack the LW gene. 
D)  The gene coding for LW is located on the same chromosome as the Rh genes. 
A)  Anti-LW reacts poorly with cord cells. 
B)  Anti-LW reacts stronger with Rh-positive cells than with Rh-negative cells. 
C)  Rh-null individuals lack the LW gene. 
D)  The gene coding for LW is located on the same chromosome as the Rh genes.

Question 7

Which IgG subclasses carry the most significance with regard to Rh antibodies?

Accepted Answer

A)  IgG1/IgG4 
B)  IgG2/IgG4 
C)  IgG3/IgG4 
D)  IgG1/IgG3 
A)  IgG1/IgG4 
B)  IgG2/IgG4 
C)  IgG3/IgG4 
D)  IgG1/IgG3

Question 8

The biochemical structure of the Rh antigens is a nonglycosylated protein, meaning:

Accepted Answer

A)  lipids are not attached to protein structure. 
B)  carbohydrates are not attached to protein structure. 
C)  glucose is attached to protein. 
D)  glycerol is attached to protein. 
A)  lipids are not attached to protein structure. 
B)  carbohydrates are not attached to protein structure. 
C)  glucose is attached to protein. 
D)  glycerol is attached to protein.

Question 9

Why is determination of Rh status crucial for obstetric patients?

Accepted Answer

A)  An Rh-positive mother can form anti-D, which will destroy D-positive red blood cells of the fetus. 
B)  All Rh-positive mothers are possible candidates for Rh immune globulin. 
C)  All Rh-negative mothers are possible candidates for Rh immune globulin. 
D)  An Rh-negative mother can form anti-D if she gives birth to an Rh-negative baby. 
A)  An Rh-positive mother can form anti-D, which will destroy D-positive red blood cells of the fetus. 
B)  All Rh-positive mothers are possible candidates for Rh immune globulin. 
C)  All Rh-negative mothers are possible candidates for Rh immune globulin. 
D)  An Rh-negative mother can form anti-D if she gives birth to an Rh-negative baby.

Question 10

In which population is the genetic Du usually found?

Accepted Answer

A)  White 
B)  Asian 
C)  Black 
D)  Native American 
A)  White 
B)  Asian 
C)  Black 
D)  Native American

Question 11

Which of the following genotypes is consistent with f antigen expression?

Accepted Answer

A)  DcE/DCe 
B)  Dce/DCE 
C)  DCe/DcE 
D)  DCe/dCE 
A)  DcE/DCe 
B)  Dce/DCE 
C)  DCe/DcE 
D)  DCe/dCE

Question 12

Which of the following statements is false?

Accepted Answer

A)  Anti-D usually stimulates complement. 
B)  Anti-D is mostly IgG. 
C)  Anti-D can cause hemolytic disease of the newborn. 
D)  None of the above 
A)  Anti-D usually stimulates complement. 
B)  Anti-D is mostly IgG. 
C)  Anti-D can cause hemolytic disease of the newborn. 
D)  None of the above

Question 13

Anti-LW will react most strongly with:

Accepted Answer

A)  adult Rh-positive RBCs. 
B)  Rh-negative RBCs. 
C)  Rh-null RBCs. 
D)  Rh-negative cord blood. 
A)  adult Rh-positive RBCs. 
B)  Rh-negative RBCs. 
C)  Rh-null RBCs. 
D)  Rh-negative cord blood.

Question 14

What is the frequency of E antigen in the general population?

Accepted Answer

A)  85% 
B)  15% 
C)  98% 
D)  30% 
A)  85% 
B)  15% 
C)  98% 
D)  30%

Question 15

What clinical manifestation may be associated with the Rh-null syndrome?

Accepted Answer

A)  Reticulocytosis 
B)  Stomatocytosis 
C)  Low hemoglobin 
D)  All of the above 
A)  Reticulocytosis 
B)  Stomatocytosis 
C)  Low hemoglobin 
D)  All of the above

Question 16

When one or more D epitopes within the entire D protein is missing it is termed.

Accepted Answer

A)  weak D 
B)  C in trans to Rh(
D)  
C)  Del 
D)  partial D 
A)  weak D 
B)  C in trans to Rh(
D)  
C)  Del 
D)  partial D

Question 17

Why must there be alpha designations in the Rosenfield system?

Accepted Answer

A)  Nomenclature applies to other blood group systems besides Rh. 
B)  Rosenfield nomenclature is only used in the Rh blood system. 
C)  Weiner and Fisher-Race use alpha designations. 
D)  None of the above 
A)  Nomenclature applies to other blood group systems besides Rh. 
B)  Rosenfield nomenclature is only used in the Rh blood system. 
C)  Weiner and Fisher-Race use alpha designations. 
D)  None of the above

Question 18

When a patient has Rh-null syndrome, what kind of packed RBCs need to be transfused?

Accepted Answer

A)  ABO compatible Rh-positive blood 
B)  ABO compatible Rh-negative blood 
C)  ABO compatible Rh-null blood 
D)  O-negative PRBCs 
A)  ABO compatible Rh-positive blood 
B)  ABO compatible Rh-negative blood 
C)  ABO compatible Rh-null blood 
D)  O-negative PRBCs

Question 19

How are the Rh antigens inherited?

Accepted Answer

A)  X-linked recessive 
B)  Codominant alleles 
C)  X-linked dominant 
D)  None of the above 
A)  X-linked recessive 
B)  Codominant alleles 
C)  X-linked dominant 
D)  None of the above

Question 20

A male patient was seen in the emergency room with an acute bleed. The recommendation from the blood supplier is to give O-positive RBCs as uncrossmatched blood. This patient has already been exposed to Rh-positive blood after a previous accident. What is a possible outcome?

Accepted Answer

A)  The patient may have a hemolytic transfusion reaction from an allo-immunized anti-D. 
B)  Anti-D is not immunogenic, and the patient probably would not have formed an anti-D. 
C)  Anti-D is not hemolytic, and even with the circulating antibody there would be no danger to the patient. 
D)  The anti-D would activate complement, and a strong intravascular transfusion reaction would occur. 
A)  The patient may have a hemolytic transfusion reaction from an allo-immunized anti-D. 
B)  Anti-D is not immunogenic, and the patient probably would not have formed an anti-D. 
C)  Anti-D is not hemolytic, and even with the circulating antibody there would be no danger to the patient. 
D)  The anti-D would activate complement, and a strong intravascular transfusion reaction would occur.

Exam 7: The Rh Blood Group System

What does the "R" represent in Rh-Hr terminology?

What is the basis of Rosenfield Rh terminology?

Which of the following Rh phenotypes invites Cw antigen testing?

Which gene combination is expressed in the greatest frequency in the black population?

The antigen ceCF is known as:

Which of the following statements regarding anti-LW is true?

Which IgG subclasses carry the most significance with regard to Rh antibodies?

The biochemical structure of the Rh antigens is a nonglycosylated protein, meaning:

Why is determination of Rh status crucial for obstetric patients?

In which population is the genetic Du usually found?

Which of the following genotypes is consistent with f antigen expression?

Which of the following statements is false?

Anti-LW will react most strongly with:

What is the frequency of E antigen in the general population?

What clinical manifestation may be associated with the Rh-null syndrome?

When one or more D epitopes within the entire D protein is missing it is termed.

Why must there be alpha designations in the Rosenfield system?

When a patient has Rh-null syndrome, what kind of packed RBCs need to be transfused?

How are the Rh antigens inherited?

A male patient was seen in the emergency room with an acute bleed. The recommendation from the blood supplier is to give O-positive RBCs as uncrossmatched blood. This patient has already been exposed to Rh-positive blood after a previous accident. What is a possible outcome?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters

Which of the following Rh phenotypes invites C^w antigen testing?

When a patient has Rh-nullsyndrome, what kind of packed RBCs need to be transfused?