Question 1

One of the most important controls of hemoglobin's affinity for oxygen is:

Accepted Answer

A)  glucose. 
B)  2,3-diphosphoglycerate (2,3-DPG). 
C)  K+. 
D)  Ca++. 
A)  glucose. 
B)  2,3-diphosphoglycerate (2,3-DPG). 
C)  K+. 
D)  Ca++. B

Question 2

The RBC membrane is relatively permeable to all of the following except:

Accepted Answer

A)  chloride. 
B)  sodium. 
C)  bicarbonate. 
D)  water. 
A)  chloride. 
B)  sodium. 
C)  bicarbonate. 
D)  water. B

Question 3

Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?

Accepted Answer

A)  Pentose phosphate shunt 
B)  Luebering-Rapoport shunt 
C)  Glycolysis 
D)  Methemoglobin reductase 
A)  Pentose phosphate shunt 
B)  Luebering-Rapoport shunt 
C)  Glycolysis 
D)  Methemoglobin reductase C

Question 4

Name the main lipid components of a red blood cell membrane.

Accepted Answer

A)  Phospholipid 
B)  Sphingomyelin 
C)  Glycolipid 
D)  Glycophorin A 
A)  Phospholipid 
B)  Sphingomyelin 
C)  Glycolipid 
D)  Glycophorin A

Question 5

Which of the following is not a commercial system approved by the FDA for screening for bacterial contamination in platelet collections?

Accepted Answer

A)  BacT/ALERT 
B)  eBDS 
C)  BACTEC 
D)  Scansytems 
A)  BacT/ALERT 
B)  eBDS 
C)  BACTEC 
D)  Scansytems

Question 6

Red blood cells frozen using the high-concentration glycerol technique are usually stored at

Accepted Answer

A)  0oC 
B)  -20oC 
C)  -65oC 
D)  -80oC 
A)  0oC 
B)  -20oC 
C)  -65oC 
D)  -80oC

Question 7

Proper agitation of platelets while they are being stored is:

Accepted Answer

A)  important because when not agitated properly the platelets will stick together and not perform properly when transfused. 
B)  important because the pH of the stored platelets will increase and the platelets will lose functionality. 
C)  important because the pH of the stored platelets will decrease and the platelets will lose functionality. 
D)  not important because it has been deemed unnecessary by the FDA. 
A)  important because when not agitated properly the platelets will stick together and not perform properly when transfused. 
B)  important because the pH of the stored platelets will increase and the platelets will lose functionality. 
C)  important because the pH of the stored platelets will decrease and the platelets will lose functionality. 
D)  not important because it has been deemed unnecessary by the FDA.

Question 8

Which type of blood storage container is no longer available for use in the United States because it may limit the viability of RBCs?

Accepted Answer

A)  Glass bottles 
B)  PVC plastic bags with DEHP 
C)  DEHP-free polyolefin containers 
D)  Latex-free plastic containers 
A)  Glass bottles 
B)  PVC plastic bags with DEHP 
C)  DEHP-free polyolefin containers 
D)  Latex-free plastic containers

Question 9

Which of the following is licensed additive solutions approved for the storage of red blood cells for 42 days?

Accepted Answer

A)  Adsol (AS-1) 
B)  Nutricel (AS-3) 
C)  Optisol (AS-5) 
D)  All of the above 
A)  Adsol (AS-1) 
B)  Nutricel (AS-3) 
C)  Optisol (AS-5) 
D)  All of the above

Question 10

All of the following areas of red blood cell biology are crucial for normal erythrocyte survival except:

Accepted Answer

A)  cellular metabolism. 
B)  RBC membrane. 
C)  site of the ABO antigen attachment. 
D)  hemoglobin structure. 
A)  cellular metabolism. 
B)  RBC membrane. 
C)  site of the ABO antigen attachment. 
D)  hemoglobin structure.

Question 11

Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?

Accepted Answer

A)  Glycolysis 
B)  Luebering-Rapoport shunt 
C)  Pentose phosphate shunt 
D)  Methemoglobin reductase 
A)  Glycolysis 
B)  Luebering-Rapoport shunt 
C)  Pentose phosphate shunt 
D)  Methemoglobin reductase

Question 12

What is the major biochemical consideration in platelet storage?

Accepted Answer

A)  Glucose metabolism 
B)  Oxygen supply 
C)  Production of carbon dioxide 
D)  Regulation of pH 
A)  Glucose metabolism 
B)  Oxygen supply 
C)  Production of carbon dioxide 
D)  Regulation of pH

Question 13

The ABO blood groups were discovered in 1901 by whom?

Accepted Answer

A)  Charles Drew 
B)  Karl Landsteiner 
C)  Loutit and Mollison 
D)  Edward Lindeman 
A)  Charles Drew 
B)  Karl Landsteiner 
C)  Loutit and Mollison 
D)  Edward Lindeman

Question 14

What does the term autologous transfusion refer to?

Accepted Answer

A)  A parent donating blood for his or her child 
B)  An individual donating blood for a friend 
C)  An individual donating blood for a relative 
D)  An individual donating blood for his or her own transfusion 
A)  A parent donating blood for his or her child 
B)  An individual donating blood for a friend 
C)  An individual donating blood for a relative 
D)  An individual donating blood for his or her own transfusion

Question 15

Which of the following is a possible future method in pathogen reduction to treat platelet components?

Accepted Answer

A)  UV light and amotosalen 
B)  Amphotericin B 
C)  Vitamin B12 and UV light 
D)  Penicillin 
A)  UV light and amotosalen 
B)  Amphotericin B 
C)  Vitamin B12 and UV light 
D)  Penicillin

Question 16

The normal position of the oxygen dissociation curve depends on three ligands normally found within the RBC. Which one of the following is not one of these ligands?

Accepted Answer

A)  H+ ions 
B)  CO2 
C)  2,3-diphosphoglycerate (2,3-DPG) 
D)  Na+ 
A)  H+ ions 
B)  CO2 
C)  2,3-diphosphoglycerate (2,3-DPG) 
D)  Na+

Question 17

What is the normal life span of an RBC?

Accepted Answer

A)  100 days 
B)  120 days 
C)  120 hours 
D)  2 days 
A)  100 days 
B)  120 days 
C)  120 hours 
D)  2 days

Question 18

Why are platelet transfusions performed?

Accepted Answer

A)  Therapeutically to stop bleeding 
B)  Prophylactically to prevent bleeding 
C)  Both reasons. 
D)  Neither reason. 
A)  Therapeutically to stop bleeding 
B)  Prophylactically to prevent bleeding 
C)  Both reasons. 
D)  Neither reason.

Question 19

All of the following biochemical changes are associated with loss of red blood cell viability upon storage except:

Accepted Answer

A)  decreased pH. 
B)  loss of red blood cell function. 
C)  increased ATP level. 
D)  decreased glucose consumption. 
A)  decreased pH. 
B)  loss of red blood cell function. 
C)  increased ATP level. 
D)  decreased glucose consumption.

Question 20

What is the correct biochemical composition of the RBC membrane?

Accepted Answer

A)  52% protein, 40% lipid, 8% carbohydrate 
B)  40% protein, 8% lipid, 52% carbohydrate 
C)  8% protein, 52% lipid, 40% carbohydrate 
D)  8% lipid, 40% carbohydrate, 52% protein 
A)  52% protein, 40% lipid, 8% carbohydrate 
B)  40% protein, 8% lipid, 52% carbohydrate 
C)  8% protein, 52% lipid, 40% carbohydrate 
D)  8% lipid, 40% carbohydrate, 52% protein

Exam 1: Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

One of the most important controls of hemoglobin's affinity for oxygen is:

The RBC membrane is relatively permeable to all of the following except:

Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?

Name the main lipid components of a red blood cell membrane.

Which of the following is not a commercial system approved by the FDA for screening for bacterial contamination in platelet collections?

Red blood cells frozen using the high-concentration glycerol technique are usually stored at

Proper agitation of platelets while they are being stored is:

Which type of blood storage container is no longer available for use in the United States because it may limit the viability of RBCs?

Which of the following is licensed additive solutions approved for the storage of red blood cells for 42 days?

All of the following areas of red blood cell biology are crucial for normal erythrocyte survival except:

Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?

What is the major biochemical consideration in platelet storage?

The ABO blood groups were discovered in 1901 by whom?

What does the term autologous transfusion refer to?

Which of the following is a possible future method in pathogen reduction to treat platelet components?

The normal position of the oxygen dissociation curve depends on three ligands normally found within the RBC. Which one of the following is not one of these ligands?

What is the normal life span of an RBC?

Why are platelet transfusions performed?

All of the following biochemical changes are associated with loss of red blood cell viability upon storage except:

What is the correct biochemical composition of the RBC membrane?

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters