Question 1

Individuals with group B blood are more common among which populations?

Accepted Answer

A)  Black/Asian 
B)  Asian/white 
C)  White/black 
D)  Hispanic/white 
A)  Black/Asian 
B)  Asian/white 
C)  White/black 
D)  Hispanic/white A

Question 2

What is the biochemical structure of secreted A, B, and H substances?

Accepted Answer

A)  Glycolipid 
B)  Glycoprotein 
C)  Sphingolipid 
D)  Ceramide 
A)  Glycolipid 
B)  Glycoprotein 
C)  Sphingolipid 
D)  Ceramide B

Question 3

Persons who inherit the h allele do not produce transferase necessary for formation of the H structure.

Accepted Answer

A)  L-fucosyl 
B)  N-acetylgalactosaminyl 
C)  D-galactosyl 
D)  D-glucosyl 
A)  L-fucosyl 
B)  N-acetylgalactosaminyl 
C)  D-galactosyl 
D)  D-glucosyl A

Question 4

Approximately how many antigen sites can be found on A2 cells?

Accepted Answer

A)  1 million 
B)  10,000 
C)  260,000 
D)  500,000 
A)  1 million 
B)  10,000 
C)  260,000 
D)  500,000

Question 5

Weak agglutination with anti-A typing sera is to be expected with which of the following blood groups?

Accepted Answer

A)  A1 
B)  A2 
C)  A3
D A2B 
A)  A1 
B)  A2 
C)  A3
D A2B

Question 6

If a group O mother gives birth to a group A baby, which of the following antibodies is usually responsible for crossing the placenta and causing hemolytic disease of the newborn (HDN)?

Accepted Answer

A)  Anti-AB 
B)  Anti-B 
C)  Anti-A 
D)  Anti-H 
A)  Anti-AB 
B)  Anti-B 
C)  Anti-A 
D)  Anti-H

Question 7

What is a lectin?

Accepted Answer

A)  A protein produced from immunized rabbits and cloned for specificity 
B)  A foreign protein that will elicit an immune response in most individuals 
C)  Seed extracts that agglutinate human cells with moderate specificity 
D)  A substance that will agglutinate sensitized cells in the presence of complement 
A)  A protein produced from immunized rabbits and cloned for specificity 
B)  A foreign protein that will elicit an immune response in most individuals 
C)  Seed extracts that agglutinate human cells with moderate specificity 
D)  A substance that will agglutinate sensitized cells in the presence of complement

Question 8

What percentage of A2 individuals produce anti-A1?

Accepted Answer

A)  5% 
B)  20% 
C)  50% 
D)  80% 
A)  5% 
B)  20% 
C)  50% 
D)  80%

Question 9

All of the following is consistent with A3 individuals except:

Accepted Answer

A)  "A" substance in saliva. 
B)  mixed field agglutination with anti-A. 
C)  4,000 antigenic sites on red blood cells. 
D)  a variable amount of "A" transferase in serum. 
A)  "A" substance in saliva. 
B)  mixed field agglutination with anti-A. 
C)  4,000 antigenic sites on red blood cells. 
D)  a variable amount of "A" transferase in serum.

Question 10

Which substance must be formed first before A or B specificity is determined?

Accepted Answer

A)  I 
B)  O 
C)  Bombay 
D)  H 
A)  I 
B)  O 
C)  Bombay 
D)  H

Question 11

Which of the following is not characteristic of antibodies within the ABO system?

Accepted Answer

A)  Antibodies are of IgM Class. 
B)  Antibodies are naturally occurring. 
C)  ABO antibodies do not activate complement. 
D)  ABO antibodies may cause immediate intravascular hemolysis. 
A)  Antibodies are of IgM Class. 
B)  Antibodies are naturally occurring. 
C)  ABO antibodies do not activate complement. 
D)  ABO antibodies may cause immediate intravascular hemolysis.

Question 12

What is the most important use for anti-B lectin?

Accepted Answer

A)  Differentiating B1 from B2 
B)  Differentiating secretors from nonsecretors 
C)  Differentiating a true B from an acquired-like B 
D)  All of the above 
A)  Differentiating B1 from B2 
B)  Differentiating secretors from nonsecretors 
C)  Differentiating a true B from an acquired-like B 
D)  All of the above

Question 13

Two drops of serum are added to one drop of A1 cells, and two drops are added to one drop of B cells; the two tubes are centrifuged. The tubes show reactivity when read macroscopically. This is an example of:

Accepted Answer

A)  forward grouping. 
B)  reverse grouping. 
C)  antibody screen. 
D)  crossmatch. 
A)  forward grouping. 
B)  reverse grouping. 
C)  antibody screen. 
D)  crossmatch.

Question 14

What would be a possible genotype of an A2B individual?

Accepted Answer

A)  A1B 
B)  A2B 
C)  A2O 
D)  A2A2 
A)  A1B 
B)  A2B 
C)  A2O 
D)  A2A2

Question 15

Which ABO group's reaction will be the weakest with anti-H lectin?

Accepted Answer

A)  A1 
B)  B 
C)  A2B 
D)  AB 
A)  A1 
B)  B 
C)  A2B 
D)  AB

Question 16

Cord blood was sent to the laboratory for blood type determination on twins A and B. Baby A demonstrated mixed-field reactions with anti-A and anti-AB and no reactivity with anti-B. Reverse grouping was not performed. Baby B showed a 1+ reaction with anti-A and anti-AB. What could be the reason for the variable reactions?

Accepted Answer

A)  Chimerism 
B)  A dimorphic cell population 
C)  Dispermy 
D)  All of the above 
A)  Chimerism 
B)  A dimorphic cell population 
C)  Dispermy 
D)  All of the above

Question 17

Which of the following indicates secretor gene control overproduction of H substance?

Accepted Answer

A)  L-fucosyltransferase is found in the saliva of secretors. 
B)  D-galactosyltransferase is found in saliva of secretors. 
C)  N-acetylgalactosaminyltransferase is found in saliva of secretors. 
D)  D-glycosyltransferase is found in saliva of secretors. 
A)  L-fucosyltransferase is found in the saliva of secretors. 
B)  D-galactosyltransferase is found in saliva of secretors. 
C)  N-acetylgalactosaminyltransferase is found in saliva of secretors. 
D)  D-glycosyltransferase is found in saliva of secretors.

Question 18

All of the following may depress antigen expression except:

Accepted Answer

A)  leukemia. 
B)  lymphoma. 
C)  coronary heart disease. 
D)  Hodgkin's disease. 
A)  leukemia. 
B)  lymphoma. 
C)  coronary heart disease. 
D)  Hodgkin's disease.

Question 19

What percentage of the type A population is A2?

Accepted Answer

A)  1% 
B)  10% 
C)  20% 
D)  80% 
A)  1% 
B)  10% 
C)  20% 
D)  80%

Question 20

What percentage of the type-A population are A1?

Accepted Answer

A)  80% 
B)  50% 
C)  20% 
D)  10% 
A)  80% 
B)  50% 
C)  20% 
D)  10%

Exam 6: The Abo Blood Group System

Individuals with group B blood are more common among which populations?

What is the biochemical structure of secreted A, B, and H substances?

Persons who inherit the h allele do not produce transferase necessary for formation of the H structure.

Approximately how many antigen sites can be found on A2 cells?

Weak agglutination with anti-A typing sera is to be expected with which of the following blood groups?

If a group O mother gives birth to a group A baby, which of the following antibodies is usually responsible for crossing the placenta and causing hemolytic disease of the newborn (HDN)?

What is a lectin?

What percentage of A2 individuals produce anti-A1?

All of the following is consistent with A3 individuals except:

Which substance must be formed first before A or B specificity is determined?

Which of the following is not characteristic of antibodies within the ABO system?

What is the most important use for anti-B lectin?

Two drops of serum are added to one drop of A1 cells, and two drops are added to one drop of B cells; the two tubes are centrifuged. The tubes show reactivity when read macroscopically. This is an example of:

What would be a possible genotype of an A2B individual?

Which ABO group's reaction will be the weakest with anti-H lectin?

Which of the following indicates secretor gene control overproduction of H substance?

All of the following may depress antigen expression except:

What percentage of the type A population is A2?

What percentage of the type-A population are A1?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters

Approximately how many antigen sites can be found on A₂ cells?

What percentage of A₂ individuals produce anti-A₁?

Two drops of serum are added to one drop of A₁ cells, and two drops are added to one drop of B cells; the two tubes are centrifuged. The tubes show reactivity when read macroscopically. This is an example of:

What would be a possible genotype of an A₂B individual?

What percentage of the type A population is A₂?

What percentage of the type-A population are A₁?