Question 1

In the black population, a mosaic form of which antigen may be found?

Accepted Answer

A)  c 
B)  E 
C)  e 
D)  C 
A)  c 
B)  E 
C)  e 
D)  C

Question 2

Rh-immune globulin is effective is preventing which type of hemolytic disease of the newborn (HDN)?

Accepted Answer

A)  Anti-c 
B)  Anti-E 
C)  Anti-D 
D)  Anti-C 
A)  Anti-c 
B)  Anti-E 
C)  Anti-D 
D)  Anti-C

Question 3

The Rh testing on a blood donor was negative at immediate spin. The tube was incubated at 37°C for 15 minutes. The tube was centrifuged and read macroscopically. The test was negative at 37°C. The tube was washed three times with saline, and two drops of AHG were added. After centrifugation, the tube yielded a 2+ reaction. How is this Rh type reported on the donor unit?

Accepted Answer

A)  Rh-positive 
B)  Rh-negative 
C)  Du-positive 
D)  Rh-variable 
A)  Rh-positive 
B)  Rh-negative 
C)  Du-positive 
D)  Rh-variable

Question 4

Why do false-negative Rh testing results occur in babies with severe hemolytic disease of the newborn due to anti-D?

Accepted Answer

A)  The cord cells may be contaminated with Wharton's jelly. 
B)  All D sites are covered by maternal anti-D, which blocks the reagent. 
C)  Antigens are not expressed yet. 
D)  None of the above 
A)  The cord cells may be contaminated with Wharton's jelly. 
B)  All D sites are covered by maternal anti-D, which blocks the reagent. 
C)  Antigens are not expressed yet. 
D)  None of the above

Question 5

Most Rh antibodies are of what immunoglobulin class?

Accepted Answer

A)  IgM 
B)  IgG 
C)  IgA 
D)  IgE 
A)  IgM 
B)  IgG 
C)  IgA 
D)  IgE

Question 6

Which of the following Rh antigens is the most immunogenic?

Accepted Answer

A)  D 
B)  C 
C)  e 
D)  E 
A)  D 
B)  C 
C)  e 
D)  E

Question 7

Of the three following categories of altered D antigen, in which variation of D antigen expression are you more likely to encounter an allo-anti-D?

Accepted Answer

A)  C in Trans to RhD 
B)  Weak D 
C)  Partial D 
D)  None of the above 
A)  C in Trans to RhD 
B)  Weak D 
C)  Partial D 
D)  None of the above

Question 8

What are the dangers of transfusing donor Rh-negative RBCs to an Rh-positive patient?

Accepted Answer

A)  There are no dangers. 
B)  A hemolytic transfusion reaction will occur. 
C)  A patient will be sensitized and will develop an Anti-D. 
D)  Most Rh-negative blood is c- and e-positive, and because of their immunogenicity the patient may form an antibody to those antigens. 
A)  There are no dangers. 
B)  A hemolytic transfusion reaction will occur. 
C)  A patient will be sensitized and will develop an Anti-D. 
D)  Most Rh-negative blood is c- and e-positive, and because of their immunogenicity the patient may form an antibody to those antigens.

Question 9

On which chromosome are the genes that code for RH proteins, namely, RHD and RHCE located?

Accepted Answer

A)  Chromosome 1 
B)  Chromosome 19 
C)  Chromosome 20 
D)  Chromosome 9 
A)  Chromosome 1 
B)  Chromosome 19 
C)  Chromosome 20 
D)  Chromosome 9

Question 10

All of the following may cause a false-negative reaction in Rh typing except:

Accepted Answer

A)  omission of reagent. 
B)  immunoglobulin coating cells. 
C)  rouleaux. 
D)  cell suspension that is too heavy. 
A)  omission of reagent. 
B)  immunoglobulin coating cells. 
C)  rouleaux. 
D)  cell suspension that is too heavy.

Question 11

The Rh antibody agglutinates what percentage of RBCs?

Accepted Answer

A)  15% 
B)  85% 
C)  50% 
D)  35% 
A)  15% 
B)  85% 
C)  50% 
D)  35%

Question 12

In the Fisher-Race nomenclature what does "d" refer to?

Accepted Answer

A)  Amorph 
B)  Silent allele 
C)  Absence of D 
D)  All of the above 
A)  Amorph 
B)  Silent allele 
C)  Absence of D 
D)  All of the above

Question 13

What does Rh genotype refer to?

Accepted Answer

A)  Antigens detected on a red blood cell by serologic methods 
B)  Antibodies detected in serum by serologic methods 
C)  Rh genes inherited from both parents 
D)  Rh genes inherited from the mother 
A)  Antigens detected on a red blood cell by serologic methods 
B)  Antibodies detected in serum by serologic methods 
C)  Rh genes inherited from both parents 
D)  Rh genes inherited from the mother

Question 14

Which antigen represents Rh3 in Rosenfield terminology?

Accepted Answer

A)  D 
B)  E 
C)  C 
D)  e 
A)  D 
B)  E 
C)  C 
D)  e

Question 15

All of the following are true regarding Rh antibodies except:

Accepted Answer

A)  Rh antibodies can bind complement on the red blood cell membrane. 
B)  An individual with a low titer Rh antibody may experience a secondary immune response on antigen exposure. 
C)  Rh antibodies may cause a delayed hemolytic transfusion reaction. 
D)  Red blood cell destruction is usually extravascular. 
A)  Rh antibodies can bind complement on the red blood cell membrane. 
B)  An individual with a low titer Rh antibody may experience a secondary immune response on antigen exposure. 
C)  Rh antibodies may cause a delayed hemolytic transfusion reaction. 
D)  Red blood cell destruction is usually extravascular.

Question 16

Where is the Rh antigen located relative to the red blood cell membrane?

Accepted Answer

A)  Integrally 
B)  Peripherally 
C)  Centrally 
D)  None of the above 
A)  Integrally 
B)  Peripherally 
C)  Centrally 
D)  None of the above

Question 17

What is the principle of the Rh-Hr (Weiner) terminology?

Accepted Answer

A)  The Rh gene produces at least three factors within an agglutinogen. 
B)  Each gene (D, C, c, E, e) produces one product or antigen. 
C)  The Rh gene produces at least three factors within an agglutinin. 
D)  Each gene is independent of the others. 
A)  The Rh gene produces at least three factors within an agglutinogen. 
B)  Each gene (D, C, c, E, e) produces one product or antigen. 
C)  The Rh gene produces at least three factors within an agglutinin. 
D)  Each gene is independent of the others.

Question 18

What does hr' refer to in the Weiner nomenclature?

Accepted Answer

A)  c 
B)  e 
C)  C 
D)  E 
A)  c 
B)  e 
C)  C 
D)  E

Question 19

What is an advantage of using chemically modified anti-D?

Accepted Answer

A)  It provides a low-protein medium. 
B)  Rh control is not necessary. 
C)  Few false-negative results are obtained. 
D)  Du testing is eliminated. 
A)  It provides a low-protein medium. 
B)  Rh control is not necessary. 
C)  Few false-negative results are obtained. 
D)  Du testing is eliminated.

Question 20

Which of the following genotypes would demonstrate the strongest expression of D antigen?

Accepted Answer

A)  Dce/dCE 
B)  DCe/dce 
C)  dce/dce 
D)  dCe/dcE 
A)  Dce/dCE 
B)  DCe/dce 
C)  dce/dce 
D)  dCe/dcE

Exam 7: The Rh Blood Group System

In the black population, a mosaic form of which antigen may be found?

Rh-immune globulin is effective is preventing which type of hemolytic disease of the newborn (HDN)?

Why do false-negative Rh testing results occur in babies with severe hemolytic disease of the newborn due to anti-D?

Most Rh antibodies are of what immunoglobulin class?

Which of the following Rh antigens is the most immunogenic?

Of the three following categories of altered D antigen, in which variation of D antigen expression are you more likely to encounter an allo-anti-D?

What are the dangers of transfusing donor Rh-negative RBCs to an Rh-positive patient?

On which chromosome are the genes that code for RH proteins, namely, RHD and RHCE located?

All of the following may cause a false-negative reaction in Rh typing except:

The Rh antibody agglutinates what percentage of RBCs?

In the Fisher-Race nomenclature what does "d" refer to?

What does Rh genotype refer to?

Which antigen represents Rh3 in Rosenfield terminology?

All of the following are true regarding Rh antibodies except:

Where is the Rh antigen located relative to the red blood cell membrane?

What is the principle of the Rh-Hr (Weiner) terminology?

What does hr' refer to in the Weiner nomenclature?

What is an advantage of using chemically modified anti-D?

Which of the following genotypes would demonstrate the strongest expression of D antigen?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

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