Question 1

Acute hemolysis of recipient RBCs may occur by ABO-incompatible antibodies in the transplant product, in which ABO incompatibility?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these

Question 2

Which of the following statement concerning graft-versus-host disease (GVHD) is TRUE?

Accepted Answer

A)  GVHD can be avoided by using leuko-reduced HPC product. 
B)  GVHD is a nonimmune-mediated disease. 
C)  GVHD results from a failure of the autologous HPC to engraft. 
D)  GVHD results from mismatches in HLA types between the donor and recipient. 
A)  GVHD can be avoided by using leuko-reduced HPC product. 
B)  GVHD is a nonimmune-mediated disease. 
C)  GVHD results from a failure of the autologous HPC to engraft. 
D)  GVHD results from mismatches in HLA types between the donor and recipient.

Question 3

Myeloablative conditioning means

Accepted Answer

A)  intervention uses reduced amounts of chemotherapy and/or radiation. 
B)  without intervention the bone marrow would not recover without HPC transplantation. 
C)  without intervention immune function is able to recover without HPC transplantation. 
D)  none of these. 
A)  intervention uses reduced amounts of chemotherapy and/or radiation. 
B)  without intervention the bone marrow would not recover without HPC transplantation. 
C)  without intervention immune function is able to recover without HPC transplantation. 
D)  none of these.

Question 4

Reduction of TA-GVHD risk is accomplished through all of the following EXCEPT:

Accepted Answer

A)  damaging donor lymphocyte DNA. 
B)  irradiation of blood products. 
C)  leukocyte reduction 
D)  pathogen-reduction techniques. 
A)  damaging donor lymphocyte DNA. 
B)  irradiation of blood products. 
C)  leukocyte reduction 
D)  pathogen-reduction techniques.

Question 5

Which incompatibility complication is most common in HPC transplant recipients?

Accepted Answer

A)  ABO 
B)  HLA 
C)  Rh 
D)  None of these 
A)  ABO 
B)  HLA 
C)  Rh 
D)  None of these

Question 6

HPC transplant recipients can be at risk for delayed granulocyte production in which ABO incompatibility?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these

Question 7

HPC-M collections are performed:

Accepted Answer

A)  using a needle to access the marrow space of the posterior iliac crest. 
B)  employing apheresis technology. 
C)  with an automated device to process blood and collect peripheral blood. 
D)  by all of these methods. 
A)  using a needle to access the marrow space of the posterior iliac crest. 
B)  employing apheresis technology. 
C)  with an automated device to process blood and collect peripheral blood. 
D)  by all of these methods.

Question 8

Autologous HPC donation is used to treat all of the following EXCEPT:

Accepted Answer

A)  Lymphoproliferative 
B)  Malignant myeloproliferative processes 
C)  Plasma cell disorders 
D)  Solid tumors 
A)  Lymphoproliferative 
B)  Malignant myeloproliferative processes 
C)  Plasma cell disorders 
D)  Solid tumors

Question 9

Transfused lymphocytes escape detection and are able to divide and harm the recipient's tissues, resulting in which type of graft-versus-host disease?

Accepted Answer

A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  None of these 
A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  None of these

Question 10

Which of the following is a cytokine used to stimulate hematopoietic progenitor cell production for harvest by apheresis?

Accepted Answer

A)  Filgrastrim 
B)  Naproxen 
C)  Progesterone 
D)  Erythropoietin 
A)  Filgrastrim 
B)  Naproxen 
C)  Progesterone 
D)  Erythropoietin

Question 11

Which type of graft-versus-host disease is usually fatal?

Accepted Answer

A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  All of these 
A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  All of these

Question 12

What percent of HPC transplants have a bidirectional ABO incompatibility?

Accepted Answer

A)  1% to 5 % 
B)  6% to 14 % 
C)  15% to 19 % 
D)  20% to 25 % 
A)  1% to 5 % 
B)  6% to 14 % 
C)  15% to 19 % 
D)  20% to 25 %

Question 13

Allogeneic HPC donation is commonly used to treat which of the following?

Accepted Answer

A)  Lymphoproliferative 
B)  Malignant myeloproliferative processes 
C)  Plasma cell disorders 
D)  Solid tumors 
A)  Lymphoproliferative 
B)  Malignant myeloproliferative processes 
C)  Plasma cell disorders 
D)  Solid tumors

Question 14

When not all of the recipient's hematopoietic progenitor cells are destroyed prior to transplantation, it is called:

Accepted Answer

A)  myeloablative conditioning. 
B)  nonmyeloablative conditioning. 
C)  syngeneic conditioning. 
D)  xerographic conditioning. 
A)  myeloablative conditioning. 
B)  nonmyeloablative conditioning. 
C)  syngeneic conditioning. 
D)  xerographic conditioning.

Question 15

What is involved in the cryopreservation of HPCs?

Accepted Answer

A)  addition of a cryoprotectant to the HPC product 
B)  freezing in a controlled-rate freezer 
C)  long-term storage in a liquid nitrogen freezer 
D)  All of these 
A)  addition of a cryoprotectant to the HPC product 
B)  freezing in a controlled-rate freezer 
C)  long-term storage in a liquid nitrogen freezer 
D)  All of these

Question 16

HPC transplant recipients can be at risk for delayed platelet production in which ABO incompatibility?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these

Question 17

What is the overall incidence of graft-versus-host disease?

Accepted Answer

A)  0% to 10% 
B)  10% to 30 % 
C)  30% to 50 % 
D)  60% to 80 % 
A)  0% to 10% 
B)  10% to 30 % 
C)  30% to 50 % 
D)  60% to 80 %

Question 18

What term is used if an HPC donor is an identical twin?

Accepted Answer

A)  Allogeneic 
B)  Autologous 
C)  Syngeneic 
D)  None of these 
A)  Allogeneic 
B)  Autologous 
C)  Syngeneic 
D)  None of these

Question 19

A transplant recipient has developed pancytopenia, with an elevation in liver enzymes and is experiencing bouts of diarrhea. This patient has most likely developed which form of GVHD?

Accepted Answer

A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  None of these 
A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  None of these

Question 20

The myeloid line of hematopoietic progenitor cells (HPC-M) includes all but which of the following?

Accepted Answer

A)  Erythrocytes 
B)  Monocytes 
C)  Dendritic cells 
D)  Basophils 
A)  Erythrocytes 
B)  Monocytes 
C)  Dendritic cells 
D)  Basophils

Exam 19: Cellular Therapy in the Transplant Setting

Acute hemolysis of recipient RBCs may occur by ABO-incompatible antibodies in the transplant product, in which ABO incompatibility?

Which of the following statement concerning graft-versus-host disease (GVHD) is TRUE?

Myeloablative conditioning means

Reduction of TA-GVHD risk is accomplished through all of the following EXCEPT:

Which incompatibility complication is most common in HPC transplant recipients?

HPC transplant recipients can be at risk for delayed granulocyte production in which ABO incompatibility?

HPC-M collections are performed:

Autologous HPC donation is used to treat all of the following EXCEPT:

Transfused lymphocytes escape detection and are able to divide and harm the recipient's tissues, resulting in which type of graft-versus-host disease?

Which of the following is a cytokine used to stimulate hematopoietic progenitor cell production for harvest by apheresis?

Which type of graft-versus-host disease is usually fatal?

What percent of HPC transplants have a bidirectional ABO incompatibility?

Allogeneic HPC donation is commonly used to treat which of the following?

When not all of the recipient's hematopoietic progenitor cells are destroyed prior to transplantation, it is called:

What is involved in the cryopreservation of HPCs?

HPC transplant recipients can be at risk for delayed platelet production in which ABO incompatibility?

What is the overall incidence of graft-versus-host disease?

What term is used if an HPC donor is an identical twin?

A transplant recipient has developed pancytopenia, with an elevation in liver enzymes and is experiencing bouts of diarrhea. This patient has most likely developed which form of GVHD?

The myeloid line of hematopoietic progenitor cells (HPC-M) includes all but which of the following?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

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