Question 1

Delayed hemolysis of recipient RBCs due to passenger lymphocyte syndrome can be seen in which ABO incompatibility?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these

Question 2

Which of these techniques best helps to reduce infections with cytomegalovirus?

Accepted Answer

A)  Collection from CMV seronegative donors 
B)  Leukoreduction 
C)  A combination of both of these 
D)  Neither of these can reduce CMV. 
A)  Collection from CMV seronegative donors 
B)  Leukoreduction 
C)  A combination of both of these 
D)  Neither of these can reduce CMV.

Question 3

Dimethyl sulfoxide (DMSO) is used to wash HPC product in order to remove which cells?

Accepted Answer

A)  Progenitor cells 
B)  Red blood cells 
C)  White blood cells 
D)  None of these. 
A)  Progenitor cells 
B)  Red blood cells 
C)  White blood cells 
D)  None of these.

Question 4

For recipients with a minor mismatch, HPC products of which group are usually selected until the recipient antibodies that are incompatible with HPC product are no longer detected?

Accepted Answer

A)  O 
B)  A 
C)  B 
D)  AB 
A)  O 
B)  A 
C)  B 
D)  AB

Question 5

Hematopoietic progenitor cell transplantation has been used to treat which of the following diseases?

Accepted Answer

A)  Adrenoleukodystrophy 
B)  Aplastic anemia 
C)  Lysosomal disorders 
D)  All of the above 
A)  Adrenoleukodystrophy 
B)  Aplastic anemia 
C)  Lysosomal disorders 
D)  All of the above

Question 6

HPC-A collections are performed:

Accepted Answer

A)  using a needle to access the marrow space of the posterior iliac crest. 
B)  employing apheresis technology. 
C)  with an automated device to process blood and collect peripheral blood. 
D)  by all of these methods. 
A)  using a needle to access the marrow space of the posterior iliac crest. 
B)  employing apheresis technology. 
C)  with an automated device to process blood and collect peripheral blood. 
D)  by all of these methods.

Question 7

Acute hemolysis of recipient RBCs may occur by ABO-incompatible antibodies in the recipient that lyse donor red blood, in which ABO incompatibility?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  None of these

Question 8

HPC transplantation using HPCs from another individual is referred to as:

Accepted Answer

A)  Allogeneic 
B)  Autologous 
C)  Syngeneic 
D)  None of these 
A)  Allogeneic 
B)  Autologous 
C)  Syngeneic 
D)  None of these

Question 9

What concentration of dimethyl sulfoxide (DMSO) is used to wash HPC product?

Accepted Answer

A)  1% 
B)  2% 
C)  5% 
D)  10% 
A)  1% 
B)  2% 
C)  5% 
D)  10%

Question 10

Donors of autologous HPC products have to be carefully screened for which of these?

Accepted Answer

A)  Congenital immune deficiencies 
B)  Human leukocyte antigen (HL
A)  type 
C)  Infectious diseases 
D)  Sickle cell disease 
A)  Congenital immune deficiencies 
B)  Human leukocyte antigen (HL
A)  type 
C)  Infectious diseases 
D)  Sickle cell disease

Question 11

What is the purpose of recipient conditioning?

Accepted Answer

A)  Destroys tumor cells 
B)  Creates a niche for donor HPC to occupy 
C)  Ensures engraftment of allogeneic product 
D)  All of these 
A)  Destroys tumor cells 
B)  Creates a niche for donor HPC to occupy 
C)  Ensures engraftment of allogeneic product 
D)  All of these

Question 12

What cells are produced as a result of hematopoiesis?

Accepted Answer

A)  Red blood cells 
B)  Platelets 
C)  White blood cells 
D)  All of these 
A)  Red blood cells 
B)  Platelets 
C)  White blood cells 
D)  All of these

Question 13

HPC products are typically manipulated to reduce the total number of contaminating red blood cells (RBCs) for recipients with which ABO incompatibility?

Accepted Answer

A)  Bidirectional 
B)  Major 
C)  Minor 
D)  All of these 
A)  Bidirectional 
B)  Major 
C)  Minor 
D)  All of these

Question 14

Which of these infectious diseases is not included in screening tests for donors of allogeneic HPC products?

Accepted Answer

A)  Hepatitis B virus (HBV) 
B)  Hepatitis C virus (HCV) 
C)  Human immunodeficiency virus (HIV) 
D)  Human papilloma virus (HPV) 
A)  Hepatitis B virus (HBV) 
B)  Hepatitis C virus (HCV) 
C)  Human immunodeficiency virus (HIV) 
D)  Human papilloma virus (HPV)

Question 15

Donor screening for HPC products includes:

Accepted Answer

A)  a physical examination. 
B)  completion of screening questionnaire. 
C)  review of relevant medical records. 
D)  all of these. 
A)  a physical examination. 
B)  completion of screening questionnaire. 
C)  review of relevant medical records. 
D)  all of these.

Question 16

Group AB plasma is best used for which type of mismatch situation?

Accepted Answer

A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  All of these 
A)  Bidirectional ABO incompatibility 
B)  Major ABO incompatibility 
C)  Minor ABO incompatibility 
D)  All of these

Question 17

HPC transplant recipients require significant blood product support because they:

Accepted Answer

A)  often have a period of hypoproliferative cytopenia. 
B)  are experiencing complications of refractoriness. 
C)  either of these 
D)  neither or these 
A)  often have a period of hypoproliferative cytopenia. 
B)  are experiencing complications of refractoriness. 
C)  either of these 
D)  neither or these

Question 18

Which type of graft-versus-host disease results if contaminating donor lymphocytes are not recognized and destroyed by the recipient's immune system?

Accepted Answer

A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  All of these 
A)  Acute 
B)  Chronic 
C)  Transfusion-associated 
D)  All of these

Question 19

What is the target collection goal for CD34 positive cells in an HPC product?

Accepted Answer

A)  1 × 106 to 2 × 106 CD34 positive cells per kilogram of recipient body weight 
B)  2 × 106 to 6 × 106 CD34 positive cells per kilogram of recipient body weight 
C)  6 × 106 to 10 × 106 CD34 positive cells per kilogram of recipient body weight 
D)  10 × 106 to 15 × 106 CD34 positive cells per kilogram of recipient body weight 
A)  1 × 106 to 2 × 106 CD34 positive cells per kilogram of recipient body weight 
B)  2 × 106 to 6 × 106 CD34 positive cells per kilogram of recipient body weight 
C)  6 × 106 to 10 × 106 CD34 positive cells per kilogram of recipient body weight 
D)  10 × 106 to 15 × 106 CD34 positive cells per kilogram of recipient body weight

Question 20

Which protein surface marker is used to assess the concentration of HPCs?

Accepted Answer

A)  CD 16 
B)  CD 34 
C)  FMC-7 
D)  HLA-DR 
A)  CD 16 
B)  CD 34 
C)  FMC-7 
D)  HLA-DR

Exam 19: Cellular Therapy in the Transplant Setting

Delayed hemolysis of recipient RBCs due to passenger lymphocyte syndrome can be seen in which ABO incompatibility?

Which of these techniques best helps to reduce infections with cytomegalovirus?

Dimethyl sulfoxide (DMSO) is used to wash HPC product in order to remove which cells?

For recipients with a minor mismatch, HPC products of which group are usually selected until the recipient antibodies that are incompatible with HPC product are no longer detected?

Hematopoietic progenitor cell transplantation has been used to treat which of the following diseases?

HPC-A collections are performed:

Acute hemolysis of recipient RBCs may occur by ABO-incompatible antibodies in the recipient that lyse donor red blood, in which ABO incompatibility?

HPC transplantation using HPCs from another individual is referred to as:

What concentration of dimethyl sulfoxide (DMSO) is used to wash HPC product?

Donors of autologous HPC products have to be carefully screened for which of these?

What is the purpose of recipient conditioning?

What cells are produced as a result of hematopoiesis?

HPC products are typically manipulated to reduce the total number of contaminating red blood cells (RBCs) for recipients with which ABO incompatibility?

Which of these infectious diseases is not included in screening tests for donors of allogeneic HPC products?

Donor screening for HPC products includes:

Group AB plasma is best used for which type of mismatch situation?

HPC transplant recipients require significant blood product support because they:

Which type of graft-versus-host disease results if contaminating donor lymphocytes are not recognized and destroyed by the recipient's immune system?

What is the target collection goal for CD34 positive cells in an HPC product?

Which protein surface marker is used to assess the concentration of HPCs?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

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