Question 1

Serologic tests determine a person's:

Accepted Answer

A)  genotype. 
B)  haplotype. 
C)  phenotype. 
D)  all of the above. 
A)  genotype. 
B)  haplotype. 
C)  phenotype. 
D)  all of the above.

Question 2

Dithiothreitol (DTT), when used alone, can destroy antigens in which blood group system?

Accepted Answer

A)  Duffy 
B)  Kell 
C)  Kidd 
D)  Lewis 
A)  Duffy 
B)  Kell 
C)  Kidd 
D)  Lewis

Question 3

How is Leb substance formed?

Accepted Answer

A)  L-fucose is added to subterminal N-acetylglucosamine of type 1 H substance. 
B)  L-fucose is added to subterminal N-acetylglucosamine of type 2 H substance. 
C)  Lea and Leb are codominant alleles located on chromosome 19. 
D)  Leb is secreted into plasma in the absence of fucosyltransferase. 
A)  L-fucose is added to subterminal N-acetylglucosamine of type 1 H substance. 
B)  L-fucose is added to subterminal N-acetylglucosamine of type 2 H substance. 
C)  Lea and Leb are codominant alleles located on chromosome 19. 
D)  Leb is secreted into plasma in the absence of fucosyltransferase.

Question 4

The Ii antigens are found on the membranes of which structures?

Accepted Answer

A)  Platelets 
B)  Leukocytes 
C)  Red blood cells 
D)  All of the above 
A)  Platelets 
B)  Leukocytes 
C)  Red blood cells 
D)  All of the above

Question 5

Which of the following is known to enhance K antigen expression in the antihuman globulin test?

Accepted Answer

A)  LISS 
B)  DTT 
C)  Albumin 
D)  Polyethylene glycol 
A)  LISS 
B)  DTT 
C)  Albumin 
D)  Polyethylene glycol

Question 6

Where are the Duffy antigens found?

Accepted Answer

A)  Red blood cells 
B)  Platelets 
C)  Lymphocytes 
D)  All of the above 
A)  Red blood cells 
B)  Platelets 
C)  Lymphocytes 
D)  All of the above

Question 7

Hemolysis associated with ficin-treated cells is more common with which red blood cells?

Accepted Answer

A)  Jk(a+b+) 
B)  Jk(a-b+) 
C)  Jk(a+b-) 
D)  All of the above 
A)  Jk(a+b+) 
B)  Jk(a-b+) 
C)  Jk(a+b-) 
D)  All of the above

Question 8

The genes that code for GPA and GPB are closely linked on the long arm of which chromosome?

Accepted Answer

A)  9 
B)  11 
C)  4 
D)  15 
A)  9 
B)  11 
C)  4 
D)  15

Question 9

Which of the following may be a possible cause for the lack of expression of Lewis antigens during pregnancy?

Accepted Answer

A)  Increased ratio of plasma lipoproteins to RBC mass 
B)  Decreased ratio of plasma lipoproteins to RBC mass 
C)  Antigenic sites blocked by IgG antibody 
D)  Antigenic sites blocked by IgM antibody 
A)  Increased ratio of plasma lipoproteins to RBC mass 
B)  Decreased ratio of plasma lipoproteins to RBC mass 
C)  Antigenic sites blocked by IgG antibody 
D)  Antigenic sites blocked by IgM antibody

Question 10

What name is attached to the Ena antigen?

Accepted Answer

A)  Envelope 
B)  Enterprise 
C)  Envision 
D)  Epitope 
A)  Envelope 
B)  Enterprise 
C)  Envision 
D)  Epitope

Question 11

A patient presented in the emergency room needing to be transfused ASAP. According to the computer, the patient had a Kell antibody 5 years ago. The antibody screen is negative now. Of the following, the best procedure to obtain suitable blood for transfusion is:

Accepted Answer

A)  to use immediate spin crossmatch compatible blood. 
B) to take the time to crossmatch the units of blood through the AHG phase. 
C) 
To antigen type the units for Kell and completely crossmatch the negative ones. 
D) 
To assume the electronic crossmatch is acceptable. 
A)  to use immediate spin crossmatch compatible blood. 
B) to take the time to crossmatch the units of blood through the AHG phase. 
C) 
To antigen type the units for Kell and completely crossmatch the negative ones. 
D) 
To assume the electronic crossmatch is acceptable.

Question 12

Why is it strongly recommended that only homozygous cells be used when ruling out Kidd antibodies?

Accepted Answer

A)  Anti-Jka may appear compatible with homozygous cells [Jk(a+b-)]. 
B)  Anti-Jka may appear compatible with heterozygous cells [Jk(a+b+)]. 
C)  It will reduce the number of false-positive results. 
D)  Options A and C 
A)  Anti-Jka may appear compatible with homozygous cells [Jk(a+b-)]. 
B)  Anti-Jka may appear compatible with heterozygous cells [Jk(a+b+)]. 
C)  It will reduce the number of false-positive results. 
D)  Options A and C

Question 13

What will happen to I antigen expression when ABH sugars are removed from red blood cells?

Accepted Answer

A)  Increased expression 
B)  Decreased expression 
C)  No effect 
D)  None of the above 
A)  Increased expression 
B)  Decreased expression 
C)  No effect 
D)  None of the above

Question 14

Persons who phenotype negative for U antigen lack Ss-SGP because of a partial or complete deletion of .

Accepted Answer

A)  GPA 
B)  GPB 
C)  N-acetylneuraminic acid 
D)  N-acetylgalactosamine 
A)  GPA 
B)  GPB 
C)  N-acetylneuraminic acid 
D)  N-acetylgalactosamine

Question 15

Which of the following are written in the order of allele, antigen, and phenotype?

Accepted Answer

A)  A1, A1, A1 
B)  A1, A1, A1 
C)  A1, A1, A1 
D)  A1, A1, A1 
A)  A1, A1, A1 
B)  A1, A1, A1 
C)  A1, A1, A1 
D)  A1, A1, A1

Question 16

The M and N antigens are found in which glycoprotein?

Accepted Answer

A)  Glycophorin A 
B)  Glycophorin B 
C)  Glycophorin C 
D)  Band 3 
A)  Glycophorin A 
B)  Glycophorin B 
C)  Glycophorin C 
D)  Band 3

Question 17

Which blood group system is not based on carbohydrates?

Accepted Answer

A)  Lewis 
B)  Rh 
C)  P 
D)  ABO 
A)  Lewis 
B)  Rh 
C)  P 
D)  ABO

Question 18

I and i antigens are found in plasma, serum, and what other possible source?

Accepted Answer

A)  Breast milk 
B)  Urine 
C)  Saliva 
D)  All of the above 
A)  Breast milk 
B)  Urine 
C)  Saliva 
D)  All of the above

Question 19

Which of the following is not involved in the Kell blood group system?

Accepted Answer

A)  Jsa 
B)  K 
C)  Kpb 
D)  Jka 
A)  Jsa 
B)  K 
C)  Kpb 
D)  Jka

Question 20

Why are Lewis antibodies not generally implicated in hemolytic disease of the newborn?

Accepted Answer

A)  Lewis antigens are well developed at birth. 
B)  Lewis antibodies are IgM and cannot cross the placenta. 
C)  Lewis antigens can readily dissociate from the red blood cell upon transfusion of Lewis-positive cells. 
D)  Lewis antibodies do not bind complement. 
A)  Lewis antigens are well developed at birth. 
B)  Lewis antibodies are IgM and cannot cross the placenta. 
C)  Lewis antigens can readily dissociate from the red blood cell upon transfusion of Lewis-positive cells. 
D)  Lewis antibodies do not bind complement.

Exam 8: Blood Group Terminology and Common Blood Groups

Serologic tests determine a person's:

Dithiothreitol (DTT), when used alone, can destroy antigens in which blood group system?

How is Leb substance formed?

The Ii antigens are found on the membranes of which structures?

Which of the following is known to enhance K antigen expression in the antihuman globulin test?

Where are the Duffy antigens found?

Hemolysis associated with ficin-treated cells is more common with which red blood cells?

The genes that code for GPA and GPB are closely linked on the long arm of which chromosome?

Which of the following may be a possible cause for the lack of expression of Lewis antigens during pregnancy?

What name is attached to the Ena antigen?

A patient presented in the emergency room needing to be transfused ASAP. According to the computer, the patient had a Kell antibody 5 years ago. The antibody screen is negative now. Of the following, the best procedure to obtain suitable blood for transfusion is:

Why is it strongly recommended that only homozygous cells be used when ruling out Kidd antibodies?

What will happen to I antigen expression when ABH sugars are removed from red blood cells?

Persons who phenotype negative for U antigen lack Ss-SGP because of a partial or complete deletion of .

Which of the following are written in the order of allele, antigen, and phenotype?

The M and N antigens are found in which glycoprotein?

Which blood group system is not based on carbohydrates?

I and i antigens are found in plasma, serum, and what other possible source?

Which of the following is not involved in the Kell blood group system?

Why are Lewis antibodies not generally implicated in hemolytic disease of the newborn?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters

How is Le^b substance formed?

What name is attached to the En^a antigen?