Exam 29: The Organic Chemistry of Metabolic Pathways

Olive oil is comprised of 80% oleic acid,CH₃(CH₂)₇CH=CH(CH₂)₇COOH.How many molecules of acetyl CoA are produced by catabolism of one molecule of oleic acid and how many passages of the β-oxidation pathway are needed for its complete catabolism?

Exhibit 29-3 Use the data below to answer the following question(s). Mevalonate is an important intermediate in the biosynthesis of cholesterol.This six-carbon compound can be formed from acetyl CoA utilizing two separate pathways.The most significant one involves the intermediate β-hydroxy-β-methylglutaryl-CoA. -Refer to Exhibit 29-3.In step 1 of the mevalonate biosynthesis,acetyl CoA is converted into acetoacetyl CoA.This reaction is analogous to:

Exhibit 29-1 MATCH a term or structure from the list below to each of the following definitions or names.Place the letter of the term or structure in the blank to the left of the definition or name which it describes. -_____ Uses the energy produced in the citric acid cycle to make ATP.

Which of the following statements about catabolism is false?

In coupled reactions,the net reaction has:

Exhibit 29-1 MATCH a term or structure from the list below to each of the following definitions or names.Place the letter of the term or structure in the blank to the left of the definition or name which it describes. -_____ Coenzyme NAD⁺ required in the β-oxidation of fatty acids,glycolysis,and the citric acid cycle.

Which of the following correctly describes glycolysis?

Exhibit 29-2 Use the data below to answer the following question(s): Under certain metabolic conditions associated with a high rate of fatty acid oxidation,the liver produces considerable quantities of acetoacetate and β-hydroxybutyrate.Acetoacetate continually undergoes spontaneous decarboxylation to yield acetone.The interrelationship of these compounds is shown below. -Refer to Exhibit 29-2.Write a mechanism for the decarboxylation of acetoacetate to yield acetone.