Question 1

Which type of protein S deficiency contains low levels of free, bound, and total protein S?

Accepted Answer

A)  Type I 
B)  Type IIa 
C)  Type IIb 
D)  All of the above 
E)  None of the above 
A)  Type I 
B)  Type IIa 
C)  Type IIb 
D)  All of the above 
E)  None of the above

Question 2

The most frequently encountered inherited thrombotic disorder in Caucasians (people of European descent) is _____________________.

Accepted Answer

A)  Protein C deficiency 
B)  Protein S deficiency 
C)  Antithrombin deficiency 
D)  APC-R 
E)  None of the above 
A)  Protein C deficiency 
B)  Protein S deficiency 
C)  Antithrombin deficiency 
D)  APC-R 
E)  None of the above

Question 3

Physiologic fibrinolysis results in the proteolytic degradation of polymerized __________.

Accepted Answer

A)  Fibrin 
B)  Plasmin 
C)  Fibrinogen 
D)  Thrombin 
E)  None of the above 
A)  Fibrin 
B)  Plasmin 
C)  Fibrinogen 
D)  Thrombin 
E)  None of the above

Question 4

Which of the following is not one of the criteria recommended by the International Society on Thrombosis and Hemostasis for the diagnosis of LA?

Accepted Answer

A)  Prolongation of at least one phospholipid-dependent clotting assay 
B)  Prolongation of at least one non-phospholipid-dependent clotting assay 
C)  Inhibition of clotting is seen in mixing studies. 
D)  Evidence that the clotting abnormality is phospholipid dependent 
E)  The diagnosis of LA makes sense based on the patient's clinical presentation and there is no reason to suspect a specific factor inhibitor. 
A)  Prolongation of at least one phospholipid-dependent clotting assay 
B)  Prolongation of at least one non-phospholipid-dependent clotting assay 
C)  Inhibition of clotting is seen in mixing studies. 
D)  Evidence that the clotting abnormality is phospholipid dependent 
E)  The diagnosis of LA makes sense based on the patient's clinical presentation and there is no reason to suspect a specific factor inhibitor.

Question 5

Which anticoagulant protein interacts with heparin resulting in conformational changes and the formation of a complex between itself and factors IIa, Xa, and heparin?

Accepted Answer

A)  Heparin cofactor 
B)  Antithrombin 
C)  Protein C 
D)  Protein S 
E)  None of the above 
A)  Heparin cofactor 
B)  Antithrombin 
C)  Protein C 
D)  Protein S 
E)  None of the above

Question 6

Unfractionated heparin (UH) therapy:

Accepted Answer

A)  Uses the same dose of heparin for all adult patients 
B)  Cannot be given by any route except intravenously 
C)  Requires monitoring approximately every 6 hours after dosing until the therapeutic interval has been achieved, after which daily monitoring is adequate 
D)  Has a wide therapeutic interval so there is little risk of bleeding or thrombosis if the dose is too high or too low 
E)  Can be monitored only via the APTT 
A)  Uses the same dose of heparin for all adult patients 
B)  Cannot be given by any route except intravenously 
C)  Requires monitoring approximately every 6 hours after dosing until the therapeutic interval has been achieved, after which daily monitoring is adequate 
D)  Has a wide therapeutic interval so there is little risk of bleeding or thrombosis if the dose is too high or too low 
E)  Can be monitored only via the APTT

Exam 28: Introduction to Thrombosis and Anticoagulant Therapy

Which type of protein S deficiency contains low levels of free, bound, and total protein S?

The most frequently encountered inherited thrombotic disorder in Caucasians (people of European descent) is _____________________.

Physiologic fibrinolysis results in the proteolytic degradation of polymerized __________.

Which of the following is not one of the criteria recommended by the International Society on Thrombosis and Hemostasis for the diagnosis of LA?

Which anticoagulant protein interacts with heparin resulting in conformational changes and the formation of a complex between itself and factors IIa, Xa, and heparin?

Unfractionated heparin (UH) therapy:

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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