Question 1

Which of the following is a meta- director?

Accepted Answer

A) -OH 
B) -Br 
C) -CH2CH2CH3 
D) -COCH3 
A) -OH 
B) -Br 
C) -CH2CH2CH3 
D) -COCH3

Question 2

Exhibit 16-6
To answer the following question(s),refer to the data below:
Isobutylbenzene is the starting material for the industrial synthesis of the NSAID,ibuprofen.  
-Refer to Exhibit 16-6.Attempts to prepare isobutylbenzene by direct Friedel-Crafts alkylation of benzene result in tert-butylbenzene as the major product.Write the complete stepwise mechanism for this reaction,showing all electron flow with arrows and showing all intermediate structures.

Accepted Answer

The answer of Exhibit 16-6
To answer the following question(s),refer to...

Question 3

Exhibit 16-2
Consider the Friedel-Crafts alkylation reaction below to answer the following question(s):  
-Refer to Exhibit 16-2.Draw the structure of the electrophilic intermediate in this reaction.

Accepted Answer

The answer of Exhibit 16-2
Consider the Friedel-Crafts alkylation reaction below...

Question 4

Exhibit 16-7
Consider the reaction below to answer the following question(s).  
-Refer to Exhibit 16-7.Draw the structure of product D.

Accepted Answer

The answer of Exhibit 16-7
Consider the reaction below to answer...

Question 5

Exhibit 16-7
Consider the reaction below to answer the following question(s).  
-Refer to Exhibit 16-7.This reaction proceeds _____ (faster or slower) than benzene.

Accepted Answer

The answer of Exhibit 16-7
Consider the reaction below to answer...

Question 6

On the structural intermediates below,show all electron flow with arrows for the nucleophilic aromatic substitution reaction of p-nitrochlorobenzene with KOH.

Accepted Answer

The answer of On the structural intermediates below,show all electron...

Question 7

Exhibit 16-2
Consider the Friedel-Crafts alkylation reaction below to answer the following question(s):  
-Refer to Exhibit 16-2.What is the role of the AlCl3 in the reaction?

Accepted Answer

The AlCl₃ is a Lewis acid catal

Question 8

Exhibit 16-1
MATCH a structure or term from the following list with each description below.Place the letter of the structure or term in the blank to the left of the description.
-______ The electrophile in aromatic nitration.

Accepted Answer

A) benzyne 
B) +NO2 
C) R3C+ 
D) electron-donating 
E) +NO
F)Meisenheimer complex
G) 
H)electron-withdrawing
I)F-TEDA-BF4 
A) benzyne 
B) +NO2 
C) R3C+ 
D) electron-donating 
E) +NO
F)Meisenheimer complex
G) 
H)electron-withdrawing
I)F-TEDA-BF4

Question 9

Exhibit 16-1
MATCH a structure or term from the following list with each description below.Place the letter of the structure or term in the blank to the left of the description.
-______ Groups which activate aromatic rings towards electrophilic substitution.

Accepted Answer

A) benzyne 
B) +NO2 
C) R3C+ 
D) electron-donating 
E) +NO
F)Meisenheimer complex
G) 
H)electron-withdrawing
I)F-TEDA-BF4 
A) benzyne 
B) +NO2 
C) R3C+ 
D) electron-donating 
E) +NO
F)Meisenheimer complex
G) 
H)electron-withdrawing
I)F-TEDA-BF4

Question 10

Which of the following is an ortho- and para- director?

Accepted Answer

A) -NO2 
B) -NH2 
C) -CN 
D) -CO2CH3 
A) -NO2 
B) -NH2 
C) -CN 
D) -CO2CH3

Exam 16: Chemistry of Benzene: Electrophilic Aromatic Substitution

Which of the following is a meta- director?

Exhibit 16-2 Consider the Friedel-Crafts alkylation reaction below to answer the following question(s): -Refer to Exhibit 16-2.Draw the structure of the electrophilic intermediate in this reaction.

Exhibit 16-7 Consider the reaction below to answer the following question(s). -Refer to Exhibit 16-7.Draw the structure of product D.

Exhibit 16-7 Consider the reaction below to answer the following question(s). -Refer to Exhibit 16-7.This reaction proceeds _____ (faster or slower) than benzene.

On the structural intermediates below,show all electron flow with arrows for the nucleophilic aromatic substitution reaction of p-nitrochlorobenzene with KOH.

Exhibit 16-2 Consider the Friedel-Crafts alkylation reaction below to answer the following question(s): -Refer to Exhibit 16-2.What is the role of the AlCl3 in the reaction?

Exhibit 16-1 MATCH a structure or term from the following list with each description below.Place the letter of the structure or term in the blank to the left of the description. -______ The electrophile in aromatic nitration.

Exhibit 16-1 MATCH a structure or term from the following list with each description below.Place the letter of the structure or term in the blank to the left of the description. -______ Groups which activate aromatic rings towards electrophilic substitution.

Which of the following is an ortho- and para- director?

Structure and Bonding

Polar Covalent Bonds;acids and Bases

Organic Compounds: Alkanes and Their Stereochemistry

Organic Compounds: Cycloalkanes and Their Stereochemistry

Stereochemistry at Tetrahedral Centers

An Overview of Organic Reactions

Par 1

Alkenes: Structure and Reactivity

Alkenes: Reactions and Synthesis

Alkynes: an Introduction to Organic Synthesis

Organohalides

Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations

Par 2

Structure Determination: Mass Spectrometry and Infrared Spectroscopy

Structure Determination: Nuclear Magnetic Resonance Spectroscopy

Conjugated Compounds and Ultraviolet Spectroscopy

Par 3

Benzene and Aromaticity

Alcohols and Phenols

Ethers and Epoxides;thiols and Sulfides

Aldehydes and Ketones: Nucleophilic Addition Reactions

Par 4

Carboxylic Acids and Nitriles

Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Carbonyl Alpha-Substitution Reactions

Carbonyl Condensation Reactions

Par 5

Amines and Heterocycles

Biomolecules: Carbohydrates

Biomolecules: Amino Acids,peptides,and Proteins

Par 7

Biomolecules: Lipids

Biomolecules: Nucleic Acids

The Organic Chemistry of Metabolic Pathways

Orbitals and Organic Chemistry: Pericyclic Reactions

Synthetic Polymers

Par 1

Filters

Exhibit 16-2 Consider the Friedel-Crafts alkylation reaction below to answer the following question(s): -Refer to Exhibit 16-2.What is the role of the AlCl₃ in the reaction?