Question 1

Persons who phenotype negative for U antigen lack Ss-SGP because of a partial or complete deletion of _______________.

Accepted Answer

A)  GPA 
B)  GPB 
C)  N-acetylneuraminic acid 
D)  N-acetylgalactosamine 
A)  GPA 
B)  GPB 
C)  N-acetylneuraminic acid 
D)  N-acetylgalactosamine

Question 2

Anti-N is known to occur in_______________ patients undergoing dialysis with equipment sterilized by formaldehyde?

Accepted Answer

A)  cancer 
B)  thyroid 
C)  renal 
D)  immunocompromised 
A)  cancer 
B)  thyroid 
C)  renal 
D)  immunocompromised

Question 3

What will happen to I antigen expression when ABH sugars are removed from red blood cells?

Accepted Answer

A)  Increased expression 
B)  Decreased expression 
C)  No effect 
D)  None of the above 
A)  Increased expression 
B)  Decreased expression 
C)  No effect 
D)  None of the above

Question 4

When red blood cells are placed in a solution of 2M urea, the red blood cells will lyse. However, it has been shown that which red blood cells are resistant to lysis?

Accepted Answer

A)  Jk(a+b-) 
B)  Jk(a+b+) 
C)  Jk(a-b-) 
D)  Jk(a-b+) 
A)  Jk(a+b-) 
B)  Jk(a+b+) 
C)  Jk(a-b-) 
D)  Jk(a-b+)

Question 5

Which of the following techniques/reagents may be useful in increasing the reactivity of anti-M?

Accepted Answer

A)  Papain pretreated cells 
B)  Anticomplement AHG reagents 
C)  Acidified serum techniques 
D)  Heterozygous MN Cells 
A)  Papain pretreated cells 
B)  Anticomplement AHG reagents 
C)  Acidified serum techniques 
D)  Heterozygous MN Cells

Question 6

What criteria must be met for an antigen to be assigned to a blood group system?

Accepted Answer

A)  Must be a red blood cell antigen 
B)  Must be assigned to a unique chromosomal locus 
C)  Must be controlled by a single gene or two closely linked genes 
D)  All of the above 
A)  Must be a red blood cell antigen 
B)  Must be assigned to a unique chromosomal locus 
C)  Must be controlled by a single gene or two closely linked genes 
D)  All of the above

Question 7

What class of immunoglobulin makes up anti-Lua?

Accepted Answer

A)  IgA 
B)  IgM 
C)  IgG 
D)  All of the above 
A)  IgA 
B)  IgM 
C)  IgG 
D)  All of the above

Question 8

What type of hemolytic transfusion reaction (HTR) occurs more frequently in patients with Jk antibodies?

Accepted Answer

A)  Febrile 
B)  Delayed 
C)  Immediate 
D)  Bacterial 
A)  Febrile 
B)  Delayed 
C)  Immediate 
D)  Bacterial

Question 9

The gene for which blood group antigen is located on the petite arm of the X chromosome?

Accepted Answer

A)  Sc1 
B)  Xga 
C)  Coa 
D)  Doa 
A)  Sc1 
B)  Xga 
C)  Coa 
D)  Doa

Question 10

Units that were positive for P² antigen had to be crossmatched with serum of a patient containing the corresponding antibody because of a short supply of blood. Which of the following crossmatch results would be considered acceptable for transfusion?

Accepted Answer

A)  IS=2+, 37=1+, AHG=0 
B)  IS=0, 37=2+, AHG=1+ 
C)  IS=1+, 37=0, AHG=0 
D)  IS=0, 37=2+, AHG=3+ 
A)  IS=2+, 37=1+, AHG=0 
B)  IS=0, 37=2+, AHG=1+ 
C)  IS=1+, 37=0, AHG=0 
D)  IS=0, 37=2+, AHG=3+

Question 11

Individuals who are Le(a-b-) and can develop Lewis antibodies without exposure to Lewis antigens are called:

Accepted Answer

A)  immune mediated. 
B)  biphasic. 
C)  naturally occurring. 
D)  autoantibodies. 
A)  immune mediated. 
B)  biphasic. 
C)  naturally occurring. 
D)  autoantibodies.

Question 12

What adult phenotype is rich in i antigen and common to the white population?

Accepted Answer

A)  I1 
B)  I2 
C)  i1 
D)  i2 
A)  I1 
B)  I2 
C)  i1 
D)  i2

Question 13

Name the substance used to neutralize antibodies to P1.

Accepted Answer

A)  Papain 
B)  Hydatid cyst fluid 
C)  Dolichos biflorus 
D)  Milk 
A)  Papain 
B)  Hydatid cyst fluid 
C)  Dolichos biflorus 
D)  Milk

Question 14

What is the most common Kidd phenotype in the black population?

Accepted Answer

A)  Jk(a+b-) 
B)  Jk(a+b+) 
C)  Jk(a-b+) 
D)  Jk(a-b-) 
A)  Jk(a+b-) 
B)  Jk(a+b+) 
C)  Jk(a-b+) 
D)  Jk(a-b-)

Question 15

The M and N antigens are found in which glycoprotein?

Accepted Answer

A)  Glycophorin A 
B)  Glycophorin B 
C)  Glycophorin C 
D)  Band 3 
A)  Glycophorin A 
B)  Glycophorin B 
C)  Glycophorin C 
D)  Band 3

Question 16

How is Le(y) formed?

Accepted Answer

A)  Fucose-B(1-4) GlcNAc is added to type 1 chain oligosaccharide. 
B)  Fucose-A(1-3) GlcNAc is added to type 2H precursor substance. 
C)  Fucose-A(1-4) GlcNAc is added to type 2H precursor substance. 
D)  Fucose-B(1-3) GlcNAc is added to type 2 chain oligosaccharide. 
A)  Fucose-B(1-4) GlcNAc is added to type 1 chain oligosaccharide. 
B)  Fucose-A(1-3) GlcNAc is added to type 2H precursor substance. 
C)  Fucose-A(1-4) GlcNAc is added to type 2H precursor substance. 
D)  Fucose-B(1-3) GlcNAc is added to type 2 chain oligosaccharide.

Question 17

What substances would be present in the saliva of a person with the LeLe HH SeSe AA genotype?

Accepted Answer

A)  A, H 
B)  A, B, H 
C)  H, B, Lea, Leb 
D)  A, H, Lea, Leb 
A)  A, H 
B)  A, B, H 
C)  H, B, Lea, Leb 
D)  A, H, Lea, Leb

Question 18

The Fy5 antigen has been shown to be the result of an interaction between Duffy genes and:

Accepted Answer

A)  Lewis 
B)  ABO 
C)  Rh 
D)  Kidd 
A)  Lewis 
B)  ABO 
C)  Rh 
D)  Kidd

Question 19

What is the ISBT designation for the Ii blood groups?

Accepted Answer

A)  200 
B)  207 
C)  300 
D)  310 
A)  200 
B)  207 
C)  300 
D)  310

Question 20

Which of the following statements regarding individuals who are Fy(a-b-) is true?

Accepted Answer

A)  The presence of Fyb in the tissue of individuals who are black who are Fy(a-b-) prevents those individuals from forming Anti-Fyb. 
B)  The presence of Fya substance in individuals who are white who are Fy(a-b-) prevents those individuals from forming Anti-Fya. 
C)  All individuals that are Fy(a-b-) are likely to form anti Fyb if exposed to the Fyb antigen. 
D)  Anti Fyb can only be produced from individuals that have inherited the Duffy gene. 
A)  The presence of Fyb in the tissue of individuals who are black who are Fy(a-b-) prevents those individuals from forming Anti-Fyb. 
B)  The presence of Fya substance in individuals who are white who are Fy(a-b-) prevents those individuals from forming Anti-Fya. 
C)  All individuals that are Fy(a-b-) are likely to form anti Fyb if exposed to the Fyb antigen. 
D)  Anti Fyb can only be produced from individuals that have inherited the Duffy gene.

Exam 8: Blood Group Terminology and the Other Blood Groups

Persons who phenotype negative for U antigen lack Ss-SGP because of a partial or complete deletion of _______________.

Anti-N is known to occur in_______________ patients undergoing dialysis with equipment sterilized by formaldehyde?

What will happen to I antigen expression when ABH sugars are removed from red blood cells?

When red blood cells are placed in a solution of 2M urea, the red blood cells will lyse. However, it has been shown that which red blood cells are resistant to lysis?

Which of the following techniques/reagents may be useful in increasing the reactivity of anti-M?

What criteria must be met for an antigen to be assigned to a blood group system?

What class of immunoglobulin makes up anti-Lua?

What type of hemolytic transfusion reaction (HTR) occurs more frequently in patients with Jk antibodies?

The gene for which blood group antigen is located on the petite arm of the X chromosome?

Units that were positive for P² antigen had to be crossmatched with serum of a patient containing the corresponding antibody because of a short supply of blood. Which of the following crossmatch results would be considered acceptable for transfusion?

Individuals who are Le(a-b-) and can develop Lewis antibodies without exposure to Lewis antigens are called:

What adult phenotype is rich in i antigen and common to the white population?

Name the substance used to neutralize antibodies to P1.

What is the most common Kidd phenotype in the black population?

The M and N antigens are found in which glycoprotein?

How is Le(y) formed?

What substances would be present in the saliva of a person with the LeLe HH SeSe AA genotype?

The Fy5 antigen has been shown to be the result of an interaction between Duffy genes and:

What is the ISBT designation for the Ii blood groups?

Which of the following statements regarding individuals who are Fy(a-b-) is true?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

What class of immunoglobulin makes up anti-Lu^a?