Question 1

Alloimmunization may result from which of the following?

Accepted Answer

A)  Bacterial contaminated red blood cells 
B)  Prior exposure to donor blood components 
C)  Transfusing an O-positive recipient with A-negative packed cells 
D)  Circulatory overload 
A)  Bacterial contaminated red blood cells 
B)  Prior exposure to donor blood components 
C)  Transfusing an O-positive recipient with A-negative packed cells 
D)  Circulatory overload B

Question 2

Which of the following symptoms are consistent with hemosiderosis?

Accepted Answer

A)  Hemoglobinuria, anemia, fever, shock 
B)  Tachycardia, fever, renal failure, shock 
C)  Anemia, jaundice, fatigue, muscle weakness 
D)  Hypotension, bloody diarrhea, renal failure, disseminated intravascular coagulation (DI
C)  
A)  Hemoglobinuria, anemia, fever, shock 
B)  Tachycardia, fever, renal failure, shock 
C)  Anemia, jaundice, fatigue, muscle weakness 
D)  Hypotension, bloody diarrhea, renal failure, disseminated intravascular coagulation (DI
C)  C

Question 3

A 35-year-old woman was transfused with 1 unit of packed red blood cells. The nurse monitoring the transfusion noticed hives on the patient's arm and an increase in body temperature. What is the choice of treatment for this patient?

Accepted Answer

A)  Leukopoor blood products 
B)  Antihistamines 
C)  Premedication with aspirin 
D)  None of the above 
A)  Leukopoor blood products 
B)  Antihistamines 
C)  Premedication with aspirin 
D)  None of the above B

Question 4

Which of the following statements is true?

Accepted Answer

A)  Dimethyl sulfoxide is toxic. 
B)  Dimethyl sulfoxide is the preservative used to prevent damage to hematopoietic progenitor cells during the freezing process. 
C)  5% to 10% dimethyl sulfoxide is the final concentration allowed before freezing. 
D)  All of the above 
A)  Dimethyl sulfoxide is toxic. 
B)  Dimethyl sulfoxide is the preservative used to prevent damage to hematopoietic progenitor cells during the freezing process. 
C)  5% to 10% dimethyl sulfoxide is the final concentration allowed before freezing. 
D)  All of the above

Question 5

Which of the following describes the etiology of GVHD?

Accepted Answer

A)  Anti-PLA1 attaches to platelet surface, permitting extravascular destruction by RES 
B)  B lymphocytes from donor blood react with major and minor histocompatibility antigens in the patient 
C)  T lymphocytes from donor blood react with major and minor histocompatibility antigens in the patient 
D)  Alloantibody in patient serum reacts with donor red blood cells 
A)  Anti-PLA1 attaches to platelet surface, permitting extravascular destruction by RES 
B)  B lymphocytes from donor blood react with major and minor histocompatibility antigens in the patient 
C)  T lymphocytes from donor blood react with major and minor histocompatibility antigens in the patient 
D)  Alloantibody in patient serum reacts with donor red blood cells

Question 6

Treatment in the event of an anaphylactic or anaphylactoid reaction should include all of the following except:

Accepted Answer

A)  stopping the transfusion. 
B)  immediately administering PPF. 
C)  keeping the intravenous line open with normal saline. 
D)  immediately administering epinephrine. 
A)  stopping the transfusion. 
B)  immediately administering PPF. 
C)  keeping the intravenous line open with normal saline. 
D)  immediately administering epinephrine.

Question 7

What is a cause of death in GVHD?

Accepted Answer

A)  Anemia 
B)  Infection 
C)  Cardiac arrest 
D)  Renal failure 
A)  Anemia 
B)  Infection 
C)  Cardiac arrest 
D)  Renal failure

Question 8

What is a possible mechanism for noncardiogenic pulmonary edema reactions?

Accepted Answer

A)  Antileukocyte antibody reacts with leukocytes and activates the reticuloendothelial system 
B)  Histamine is released from mast cells, increasing vascular dilation and fluidity to tissues 
C)  Antileukocyte antibody reacts in donor or patient plasma, initiating complement mediated pulmonary capillary endothelial injury 
D)  None of the above 
A)  Antileukocyte antibody reacts with leukocytes and activates the reticuloendothelial system 
B)  Histamine is released from mast cells, increasing vascular dilation and fluidity to tissues 
C)  Antileukocyte antibody reacts in donor or patient plasma, initiating complement mediated pulmonary capillary endothelial injury 
D)  None of the above

Question 9

All of the following are immediate nonhemolytic transfusion reactions, except:

Accepted Answer

A)  being febrile. 
B)  PTP. 
C)  anaphylaxis. 
D)  an allergic response. 
A)  being febrile. 
B)  PTP. 
C)  anaphylaxis. 
D)  an allergic response.

Question 10

Hematopoietic progenitor cell transplantation has been used to treat which of the following diseases?

Accepted Answer

A)  Aplastic anemia 
B)  Wiskott-Aldricht syndrome 
C)  Adrenoleukodystrophy 
D)  Lysosomal disorders 
E)  All of the above 
A)  Aplastic anemia 
B)  Wiskott-Aldricht syndrome 
C)  Adrenoleukodystrophy 
D)  Lysosomal disorders 
E)  All of the above

Question 11

An O-positive patient transfused with A-positive red blood cells would experience which of the following clinical manifestations?

Accepted Answer

A)  Acute hemolysis 
B)  Delayed hemolytic transfusion reaction 
C)  Anaphylaxis 
D)  External hemolysis 
A)  Acute hemolysis 
B)  Delayed hemolytic transfusion reaction 
C)  Anaphylaxis 
D)  External hemolysis

Question 12

Which of the following may be a factor in a nonimmune transfusion reaction?

Accepted Answer

A)  Post-transfusion purpura 
B)  Circulatory overload 
C)  Allergic reaction 
D)  Immediate hemolytic transfusion reaction 
A)  Post-transfusion purpura 
B)  Circulatory overload 
C)  Allergic reaction 
D)  Immediate hemolytic transfusion reaction

Question 13

Iron overload is synonymous with which of the following terms?

Accepted Answer

A)  Circulatory overload 
B)  Transfusion hemosiderosis 
C)  Pulmonary edema 
D)  Transferrin saturation 
A)  Circulatory overload 
B)  Transfusion hemosiderosis 
C)  Pulmonary edema 
D)  Transferrin saturation

Question 14

For a patient who has suffered an acute hemolytic transfusion reaction, the primary treatment goal should be to:

Accepted Answer

A)  prevent alloimmunization. 
B)  diminish chills and fever and make the patient comfortable. 
C)  prevent hemoglobinemia. 
D)  reverse hypotension and minimize renal damage. 
A)  prevent alloimmunization. 
B)  diminish chills and fever and make the patient comfortable. 
C)  prevent hemoglobinemia. 
D)  reverse hypotension and minimize renal damage.

Question 15

The principle clinical signs of extravascular hemolysis include:

Accepted Answer

A)  bilirubinemia mostly of the direct type. 
B)  hemoglobinuria. 
C)  positive DAT. 
D)  bilirubinemia and positive DAT. 
A)  bilirubinemia mostly of the direct type. 
B)  hemoglobinuria. 
C)  positive DAT. 
D)  bilirubinemia and positive DAT.

Question 16

What is a common finding in a DHTR?

Accepted Answer

A)  DIC 
B)  Jaundice 
C)  Renal failure 
D)  Hypotension 
A)  DIC 
B)  Jaundice 
C)  Renal failure 
D)  Hypotension

Question 17

Which of the following is consistent with bacterial contamination reactions?

Accepted Answer

A)  The organism is a fastidious anaerobe. 
B)  The organism thrives in warm temperatures. 
C)  The organism thrives in cold temperatures. 
D)  The organism exhibits motility. 
A)  The organism is a fastidious anaerobe. 
B)  The organism thrives in warm temperatures. 
C)  The organism thrives in cold temperatures. 
D)  The organism exhibits motility.

Question 18

A negative direct antiglobulin test (DAT) is found in all of the following transfusion reactions except:

Accepted Answer

A)  Acute nonimmune hemolytic transfusion reaction 
B)  Febrile nonhemolytic transfusion reaction 
C)  Acute immune hemolytic transfusion reaction 
D)  Transfusion-associated sepsis 
A)  Acute nonimmune hemolytic transfusion reaction 
B)  Febrile nonhemolytic transfusion reaction 
C)  Acute immune hemolytic transfusion reaction 
D)  Transfusion-associated sepsis

Question 19

Which of the following is an indicator of acute immune hemolytic transfusion reaction?

Accepted Answer

A)  Increased haptoglobin 
B)  Increased hemoglobin 
C)  Decreased LDH 
D)  Increased bilirubin 
A)  Increased haptoglobin 
B)  Increased hemoglobin 
C)  Decreased LDH 
D)  Increased bilirubin

Question 20

Which of the following is characterized by a rapid onset of thrombocytopenia due to anamnestic production of platelet antibody?

Accepted Answer

A)  GVHD 
B)  Alloimmunization 
C)  PTP 
D)  Iron overload 
A)  GVHD 
B)  Alloimmunization 
C)  PTP 
D)  Iron overload

Exam 17: Cellular Therapy

Alloimmunization may result from which of the following?

Which of the following symptoms are consistent with hemosiderosis?

A 35-year-old woman was transfused with 1 unit of packed red blood cells. The nurse monitoring the transfusion noticed hives on the patient's arm and an increase in body temperature. What is the choice of treatment for this patient?

Which of the following statements is true?

Which of the following describes the etiology of GVHD?

Treatment in the event of an anaphylactic or anaphylactoid reaction should include all of the following except:

What is a cause of death in GVHD?

What is a possible mechanism for noncardiogenic pulmonary edema reactions?

All of the following are immediate nonhemolytic transfusion reactions, except:

Hematopoietic progenitor cell transplantation has been used to treat which of the following diseases?

An O-positive patient transfused with A-positive red blood cells would experience which of the following clinical manifestations?

Which of the following may be a factor in a nonimmune transfusion reaction?

Iron overload is synonymous with which of the following terms?

For a patient who has suffered an acute hemolytic transfusion reaction, the primary treatment goal should be to:

The principle clinical signs of extravascular hemolysis include:

What is a common finding in a DHTR?

Which of the following is consistent with bacterial contamination reactions?

A negative direct antiglobulin test (DAT) is found in all of the following transfusion reactions except:

Which of the following is an indicator of acute immune hemolytic transfusion reaction?

Which of the following is characterized by a rapid onset of thrombocytopenia due to anamnestic production of platelet antibody?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

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