Question 1

Which of the following indicates a hemolytic process?

Accepted Answer

A)  Pre-transfusion plasma is yellow; post-transfusion plasma is red. 
B)  Pre-transfusion plasma is yellow; post-transfusion plasma is yellow. 
C)  Pre-transfusion plasma is red; post-transfusion plasma is yellow. 
D)  None of the above. 
A)  Pre-transfusion plasma is yellow; post-transfusion plasma is red. 
B)  Pre-transfusion plasma is yellow; post-transfusion plasma is yellow. 
C)  Pre-transfusion plasma is red; post-transfusion plasma is yellow. 
D)  None of the above.

Question 2

The final bacterial culture was positive for hematopoietic progenitor cell batch. What must be done with this batch?

Accepted Answer

A)  The batch must be discarded. 
B)  Broad spectrum antibiotics can be given to the patient and the batch infused. 
C)  Have a sensitivity done on the culture and administer the batch, as well as provide antibiotics to which the bacteria are sensitive to the patient. 
D)  The batch can be irradiated and then transfused. 
A)  The batch must be discarded. 
B)  Broad spectrum antibiotics can be given to the patient and the batch infused. 
C)  Have a sensitivity done on the culture and administer the batch, as well as provide antibiotics to which the bacteria are sensitive to the patient. 
D)  The batch can be irradiated and then transfused.

Question 3

Which of the following should be collected 5 to 7 hours after transfusion for unconjugated bilirubin determination?

Accepted Answer

A)  EDTA blood specimen 
B)  Clotted blood specimen 
C)  Post-transfusion urine specimen 
D)  Heparinized blood specimen 
A)  EDTA blood specimen 
B)  Clotted blood specimen 
C)  Post-transfusion urine specimen 
D)  Heparinized blood specimen

Question 4

Which of the following questions should be asked when investigating a transfusion reaction?

Accepted Answer

A)  How many milliliters of red blood cells were transfused? 
B)  What time of day was the donor unit collected? 
C)  What methodology was used for serologic testing? 
D)  What was the donor unit hematocrit? 
A)  How many milliliters of red blood cells were transfused? 
B)  What time of day was the donor unit collected? 
C)  What methodology was used for serologic testing? 
D)  What was the donor unit hematocrit?

Question 5

What symptom would not usually be found in a bacterial contamination reaction?

Accepted Answer

A)  Tachycardia 
B)  Hypotension 
C)  Hemoglobinuria 
D)  Fever 
A)  Tachycardia 
B)  Hypotension 
C)  Hemoglobinuria 
D)  Fever

Question 6

Bone marrow transplants and peripheral blood stem cell transplantation (PBSCT) are most commonly used in the treatment of which of the following diseases?

Accepted Answer

A)  Lymphoma 
B)  Multiple myeloma 
C)  Neuroblastoma 
D)  All of the above 
A)  Lymphoma 
B)  Multiple myeloma 
C)  Neuroblastoma 
D)  All of the above

Question 7

When not all of the recipient's hematopoietic progenitor cells are destroyed prior to transplantation, it is called:

Accepted Answer

A)  myeloablative conditioning. 
B)  nonmyeloablative conditioning. 
C)  syngeneic conditioning. 
D)  chimerism. 
A)  myeloablative conditioning. 
B)  nonmyeloablative conditioning. 
C)  syngeneic conditioning. 
D)  chimerism.

Question 8

Which of the following is a cytokine used to stimulate hematopoietic progenitor cell production for harvest by apheresis?

Accepted Answer

A)  Filgrastrim 
B)  Naproxen 
C)  Progesterone 
D)  Erythropoietin 
A)  Filgrastrim 
B)  Naproxen 
C)  Progesterone 
D)  Erythropoietin

Question 9

Persons with a documented history of anaphylactic reactions should be transfused with _____blood products.

Accepted Answer

A)  IgE-deficient 
B)  leukodepleted 
C)  washed 
D)  irradiated 
A)  IgE-deficient 
B)  leukodepleted 
C)  washed 
D)  irradiated

Question 10

Which of the following is compromised by iron overload?

Accepted Answer

A)  Heart 
B)  Liver 
C)  Endocrine glands 
D)  All of the above 
A)  Heart 
B)  Liver 
C)  Endocrine glands 
D)  All of the above

Question 11

What groups are at risk for graft-versus-host disease (GVHD) as a result of transfusion?

Accepted Answer

A)  Polycythemia vera patients undergoing a therapeutic phlebotomy 
B)  Fetuses receiving an intrauterine transfusion 
C)  Patients receiving a directed donation from a first-degree relative 
D)  Options B and C 
A)  Polycythemia vera patients undergoing a therapeutic phlebotomy 
B)  Fetuses receiving an intrauterine transfusion 
C)  Patients receiving a directed donation from a first-degree relative 
D)  Options B and C

Question 12

All of the following are symptoms of an allergic reaction except:

Accepted Answer

A)  pruritus. 
B)  local erythema. 
C)  anemia. 
D)  hives. 
A)  pruritus. 
B)  local erythema. 
C)  anemia. 
D)  hives.

Question 13

Which of the following clinical manifestations is not included in the physically or chemically induced transfusion reactions?

Accepted Answer

A)  Citrate toxicity 
B)  Hyperkalemia 
C)  Hemosiderosis 
D)  Factor VIII depletion 
A)  Citrate toxicity 
B)  Hyperkalemia 
C)  Hemosiderosis 
D)  Factor VIII depletion

Question 14

Upon investigation of a DHTR, what should be included in the medical history?

Accepted Answer

A)  Previous transfusion 
B)  Pregnancies 
C)  Transfusion reactions 
D)  All of the above 
A)  Previous transfusion 
B)  Pregnancies 
C)  Transfusion reactions 
D)  All of the above

Question 15

What treatment is recommended following a bacterial contamination reaction?

Accepted Answer

A)  Plasma protein fraction (PPF) 
B)  Broad-spectrum antibiotics 
C)  Aspirin 
D)  Epinephrine 
A)  Plasma protein fraction (PPF) 
B)  Broad-spectrum antibiotics 
C)  Aspirin 
D)  Epinephrine

Question 16

The presence of intact red blood cells in microscopic urinalysis examination indicates:

Accepted Answer

A)  bleeding. 
B)  hemolysis. 
C)  hemosiderinuria. 
D)  bilirubinemia. 
A)  bleeding. 
B)  hemolysis. 
C)  hemosiderinuria. 
D)  bilirubinemia.

Question 17

What type of hemolysis is implicated in a DHTR caused by primary alloimmunization?

Accepted Answer

A)  Extravascular 
B)  Intravascular 
C)  Nonimmune 
D)  None of the above 
A)  Extravascular 
B)  Intravascular 
C)  Nonimmune 
D)  None of the above

Question 18

Treatment of post-transfusion purpura (PTP) with_____ is not advocated in medical practice.

Accepted Answer

A)  plasmapheresis 
B)  prednisone 
C)  platelet transfusions 
D)  exchange transfusions 
A)  plasmapheresis 
B)  prednisone 
C)  platelet transfusions 
D)  exchange transfusions

Question 19

What type of hemolysis accompanies an anaphylactic reaction?

Accepted Answer

A)  Intravascular 
B)  Extravascular 
C)  Acute 
D)  None of the above 
A)  Intravascular 
B)  Extravascular 
C)  Acute 
D)  None of the above

Question 20

What is the physiologic mechanism of histamine?

Accepted Answer

A)  Histamine is released when the allergen-reagin complex attaches to the surface of basophils, increasing vascular dilation and permeability 
B)  Histamine is released when the allergen-reagin complex attaches to the surface of tissue mast cells, increasing vascular dilation and permeability 
C)  Histamine is released when the allergen-reagin complex attaches to the surface of eosinophils, increasing vascular dilation and permeability 
D)  Histamine is released when the allergen-reagin complex attaches to the surface of tissue mast cells, decreasing vascular dilation and permeability 
A)  Histamine is released when the allergen-reagin complex attaches to the surface of basophils, increasing vascular dilation and permeability 
B)  Histamine is released when the allergen-reagin complex attaches to the surface of tissue mast cells, increasing vascular dilation and permeability 
C)  Histamine is released when the allergen-reagin complex attaches to the surface of eosinophils, increasing vascular dilation and permeability 
D)  Histamine is released when the allergen-reagin complex attaches to the surface of tissue mast cells, decreasing vascular dilation and permeability

Exam 17: Cellular Therapy

Which of the following indicates a hemolytic process?

The final bacterial culture was positive for hematopoietic progenitor cell batch. What must be done with this batch?

Which of the following should be collected 5 to 7 hours after transfusion for unconjugated bilirubin determination?

Which of the following questions should be asked when investigating a transfusion reaction?

What symptom would not usually be found in a bacterial contamination reaction?

Bone marrow transplants and peripheral blood stem cell transplantation (PBSCT) are most commonly used in the treatment of which of the following diseases?

When not all of the recipient's hematopoietic progenitor cells are destroyed prior to transplantation, it is called:

Which of the following is a cytokine used to stimulate hematopoietic progenitor cell production for harvest by apheresis?

Persons with a documented history of anaphylactic reactions should be transfused with _____blood products.

Which of the following is compromised by iron overload?

What groups are at risk for graft-versus-host disease (GVHD) as a result of transfusion?

All of the following are symptoms of an allergic reaction except:

Which of the following clinical manifestations is not included in the physically or chemically induced transfusion reactions?

Upon investigation of a DHTR, what should be included in the medical history?

What treatment is recommended following a bacterial contamination reaction?

The presence of intact red blood cells in microscopic urinalysis examination indicates:

What type of hemolysis is implicated in a DHTR caused by primary alloimmunization?

Treatment of post-transfusion purpura (PTP) with_____ is not advocated in medical practice.

What type of hemolysis accompanies an anaphylactic reaction?

What is the physiologic mechanism of histamine?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

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