Question 1

What is the pathophysiological cause surrounding anaphylactic and anaphylactoid reactions?

Accepted Answer

A)  Antibody in patient serum is detected 3 to 7 days after transfusion, reacting with donor red blood cells 
B)  Donor plasma has reagins (IgE or Ig
A)  that combine with allergens in patient plasma 
C)  A patient who is deficient in IgE develops IgE antibodies via sensitization from transfusion or pregnancy 
D)  A patient who is deficient in IgA develops IgA antibodies via sensitization from transfusion or pregnancy 
A)  Antibody in patient serum is detected 3 to 7 days after transfusion, reacting with donor red blood cells 
B)  Donor plasma has reagins (IgE or Ig
A)  that combine with allergens in patient plasma 
C)  A patient who is deficient in IgE develops IgE antibodies via sensitization from transfusion or pregnancy 
D)  A patient who is deficient in IgA develops IgA antibodies via sensitization from transfusion or pregnancy

Question 2

Besides hemoglobin, what other protein can cause a pink discoloration of serum or plasma in association with muscle trauma?

Accepted Answer

A)  Myosin 
B)  Albumin 
C)  Haptoglobin 
D)  Myoglobin 
A)  Myosin 
B)  Albumin 
C)  Haptoglobin 
D)  Myoglobin

Question 3

The morbidity and mortality is highest for which adverse reaction to hematopoietic progenitor cell transplantation?

Accepted Answer

A)  CMV 
B)  HIV 
C)  TA-GVHD 
D)  ABO incompatibility 
A)  CMV 
B)  HIV 
C)  TA-GVHD 
D)  ABO incompatibility

Question 4

Which of the following types of blood should be transfused if necessary prior to a patient receiving a hematopoietic progenitor cell transplant?

Accepted Answer

A)  Leukoreduced 
B)  CMV-negative 
C)  Gamma irradiated 
D)  All of the above 
A)  Leukoreduced 
B)  CMV-negative 
C)  Gamma irradiated 
D)  All of the above

Question 5

Which of the following is the most common transfusion reaction reported to blood banks?

Accepted Answer

A)  Anaphylactic reaction 
B)  Febrile reaction 
C)  Intravascular hemolytic reaction 
D)  Extravascular hemolytic reaction 
A)  Anaphylactic reaction 
B)  Febrile reaction 
C)  Intravascular hemolytic reaction 
D)  Extravascular hemolytic reaction

Question 6

How could a potential alloimmunizaton due to Anti-K be prevented?

Accepted Answer

A)  Matching of donor and recipient red blood cell phenotype 
B)  Use of third-generation bedside leukocyte filters 
C)  Use of washed red blood cells 
D)  Use of apheresed platelets 
A)  Matching of donor and recipient red blood cell phenotype 
B)  Use of third-generation bedside leukocyte filters 
C)  Use of washed red blood cells 
D)  Use of apheresed platelets

Question 7

Immediate transfusion reaction procedures consist of all of the following except:

Accepted Answer

A)  clerical check. 
B)  DAT. 
C)  serum haptoglobin. 
D)  visual check. 
A)  clerical check. 
B)  DAT. 
C)  serum haptoglobin. 
D)  visual check.

Question 8

What may be found in the serum of a person who is exhibiting signs of a noncardiogenic pulmonary edema reaction?

Accepted Answer

A)  Red blood cell alloantibody 
B)  IgA antibody 
C)  Antileukocyte antibody 
D)  Allergen 
A)  Red blood cell alloantibody 
B)  IgA antibody 
C)  Antileukocyte antibody 
D)  Allergen

Question 9

What should be done in the transfusion process when the patient temperature spikes from 37.5°C to 38.5°C within 30 minutes of transfusion?

Accepted Answer

A)  Continue the transfusion. 
B)  Stop the transfusion and keep the intravenous line open. 
C)  Treat with diphenhydramine (Benadryl). 
D)  Affix a leukocyte filter to transfusion line. 
A)  Continue the transfusion. 
B)  Stop the transfusion and keep the intravenous line open. 
C)  Treat with diphenhydramine (Benadryl). 
D)  Affix a leukocyte filter to transfusion line.

Question 10

Persons diagnosed with chronic renal failure and hemosiderosis should be treated with:

Accepted Answer

A)  prednisone. 
B)  desferrioxamine. 
C)  neocyte transfusion. 
D)  washed red blood cells. 
A)  prednisone. 
B)  desferrioxamine. 
C)  neocyte transfusion. 
D)  washed red blood cells.

Question 11

Which of the following is not a symptom of noncardiogenic pulmonary edema?

Accepted Answer

A)  Hypervolemia 
B)  Fever 
C)  Hypotension 
D)  Coughing 
A)  Hypervolemia 
B)  Fever 
C)  Hypotension 
D)  Coughing

Question 12

Which mechanism may play a role in fever development in an FNHTR?

Accepted Answer

A)  Release of pyrogens from transfused white blood cells 
B)  The production of interleukin-6 by the complement system 
C)  Synthesis of prostaglandins (PGE±) in hypothalamic cells by interleukin-6 
D)  None of the above 
A)  Release of pyrogens from transfused white blood cells 
B)  The production of interleukin-6 by the complement system 
C)  Synthesis of prostaglandins (PGE±) in hypothalamic cells by interleukin-6 
D)  None of the above

Question 13

When checking out a unit of blood to the floor:

Accepted Answer

A)  the nurse must provide a piece of paper with at least two patient identifiers and preferably, depending on the system, a unique blood bank band number 
B)  you must visually check and document that the unit is free from hemolysis or possible bacterial contamination 
C)  you must document who is checking out the blood and transporting it 
D)  All of the above 
A)  the nurse must provide a piece of paper with at least two patient identifiers and preferably, depending on the system, a unique blood bank band number 
B)  you must visually check and document that the unit is free from hemolysis or possible bacterial contamination 
C)  you must document who is checking out the blood and transporting it 
D)  All of the above

Question 14

Which of the following best describes a transfusion reaction?

Accepted Answer

A)  An urticarial response to blood products occurring 1 to 2 hours after infusion 
B)  A physiologic response to a blood product transfused 5 to 10 days before host symptoms 
C)  Any unfavorable transfusion-related event occurring in a patient during or after transfusion of blood components 
D)  None of the above 
A)  An urticarial response to blood products occurring 1 to 2 hours after infusion 
B)  A physiologic response to a blood product transfused 5 to 10 days before host symptoms 
C)  Any unfavorable transfusion-related event occurring in a patient during or after transfusion of blood components 
D)  None of the above

Question 15

All of the following are diseases that can mimic a transfusion reaction except:

Accepted Answer

A)  AML. 
B)  hemoglobin C disease. 
C)  G6PD deficiency. 
D)  PNH. 
A)  AML. 
B)  hemoglobin C disease. 
C)  G6PD deficiency. 
D)  PNH.

Question 16

Which patients are not at risk for circulatory overload?

Accepted Answer

A)  Patients with iron-deficiency anemia 
B)  Pediatric patients 
C)  Geriatric patients 
D)  Persons homozygous for hemoglobin S 
A)  Patients with iron-deficiency anemia 
B)  Pediatric patients 
C)  Geriatric patients 
D)  Persons homozygous for hemoglobin S

Question 17

Alloimmunization is categorized as what type of transfusion reaction?

Accepted Answer

A)  Immediate nonhemolytic 
B)  Immediate hemolytic 
C)  Delayed nonhemolytic 
D)  Delayed hemolytic 
A)  Immediate nonhemolytic 
B)  Immediate hemolytic 
C)  Delayed nonhemolytic 
D)  Delayed hemolytic

Question 18

Which of the following organisms have been implicated in bacterial contamination reactions?

Accepted Answer

A)  Corynebacterium flavescens 
B)  Yersinia enterocolitica 
C)  Enterobacter aerogenes 
D)  Clostridium perfringens 
A)  Corynebacterium flavescens 
B)  Yersinia enterocolitica 
C)  Enterobacter aerogenes 
D)  Clostridium perfringens

Question 19

Persons with PTP exhibit thrombocytopenia with platelet counts as low as 10,000 per µL. What other complications might be present?

Accepted Answer

A)  Hematuria 
B)  Hypotension 
C)  Fever 
D)  DIC 
A)  Hematuria 
B)  Hypotension 
C)  Fever 
D)  DIC

Question 20

What is the purpose of performing serial hemoglobin and hematocrit after a blood transfusion?

Accepted Answer

A)  To detect the presence of hemoglobinemia 
B)  To monitor platelet refractoriness 
C)  To monitor the therapeutic or nontherapeutic response 
D)  To monitor the efficacy of clotting factors 
A)  To detect the presence of hemoglobinemia 
B)  To monitor platelet refractoriness 
C)  To monitor the therapeutic or nontherapeutic response 
D)  To monitor the efficacy of clotting factors

Exam 17: Cellular Therapy

What is the pathophysiological cause surrounding anaphylactic and anaphylactoid reactions?

Besides hemoglobin, what other protein can cause a pink discoloration of serum or plasma in association with muscle trauma?

The morbidity and mortality is highest for which adverse reaction to hematopoietic progenitor cell transplantation?

Which of the following types of blood should be transfused if necessary prior to a patient receiving a hematopoietic progenitor cell transplant?

Which of the following is the most common transfusion reaction reported to blood banks?

How could a potential alloimmunizaton due to Anti-K be prevented?

Immediate transfusion reaction procedures consist of all of the following except:

What may be found in the serum of a person who is exhibiting signs of a noncardiogenic pulmonary edema reaction?

What should be done in the transfusion process when the patient temperature spikes from 37.5°C to 38.5°C within 30 minutes of transfusion?

Persons diagnosed with chronic renal failure and hemosiderosis should be treated with:

Which of the following is not a symptom of noncardiogenic pulmonary edema?

Which mechanism may play a role in fever development in an FNHTR?

When checking out a unit of blood to the floor:

Which of the following best describes a transfusion reaction?

All of the following are diseases that can mimic a transfusion reaction except:

Which patients are not at risk for circulatory overload?

Alloimmunization is categorized as what type of transfusion reaction?

Which of the following organisms have been implicated in bacterial contamination reactions?

Persons with PTP exhibit thrombocytopenia with platelet counts as low as 10,000 per µL. What other complications might be present?

What is the purpose of performing serial hemoglobin and hematocrit after a blood transfusion?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

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