Question 1

Which of the following mother/infant blood types would be considered at risk for ABO hemolytic disease of the fetus and newborn?

Accepted Answer

A)  Mother is group O; baby is group B. 
B)  Mother is group O; baby is group O. 
C)  Mother is group AB; baby is group B. 
D)  Mother is group A; baby is group O. 
A)  Mother is group O; baby is group B. 
B)  Mother is group O; baby is group O. 
C)  Mother is group AB; baby is group B. 
D)  Mother is group A; baby is group O. A

Question 2

The antibody titer of maternal antibody is directly proportional to severity of HDFN.

Accepted Answer

A) True 
 B)False  False

Question 3

What is done to prevent HDFN caused by maternal anti-Jka antibody formation?

Accepted Answer

A)  Give Jka immune globulin. 
B)  Monitor the mother's antibody level. 
C)  Prevent formation of Jka-positive cells in the fetus. 
D)  No action is necessary; anti-Jka will not cause HDFN. 
A)  Give Jka immune globulin. 
B)  Monitor the mother's antibody level. 
C)  Prevent formation of Jka-positive cells in the fetus. 
D)  No action is necessary; anti-Jka will not cause HDFN. B

Question 4

Cannulation of the umbilical vein under ultrasound guidance is known as:

Accepted Answer

A)  cordocentesis. 
B)  amniocentesis. 
C)  apheresis. 
D)  pericardiocentesis. 
A)  cordocentesis. 
B)  amniocentesis. 
C)  apheresis. 
D)  pericardiocentesis.

Question 5

All of the following are characteristic of ABO hemolytic disease of the fetus and newborn (HDFN) except:

Accepted Answer

A)  the mother is group O. 
B)  the mother has anti-A, B. 
C)  the antibody is IgM. 
D)  the infant has mild HDFN. 
A)  the mother is group O. 
B)  the mother has anti-A, B. 
C)  the antibody is IgM. 
D)  the infant has mild HDFN.

Question 6

When is the antenatal dose of Rh-immune globulin given?

Accepted Answer

A)  20 weeks 
B)  13 weeks 
C)  28 weeks 
D)  36 weeks 
A)  20 weeks 
B)  13 weeks 
C)  28 weeks 
D)  36 weeks

Question 7

Which IgG subclass carries more potency in red blood cell hemolysis?

Accepted Answer

A)  IgG2 
B)  IgG3 
C)  IgG4 
D)  None of the above 
A)  IgG2 
B)  IgG3 
C)  IgG4 
D)  None of the above

Question 8

What is the physiological mechanism of Rh-immune globulin?

Accepted Answer

A)  Attachment of fetal Rh-positive red blood cells in fetal circulation, inhibiting production of anti-D 
B)  Attachment of maternal Rh-negative red blood cells in maternal circulation, inhibiting production of anti-D 
C)  Attachment of fetal Rh-positive red blood cells in maternal circulation, inhibiting production of anti-D 
D)  Attachment of fetal Rh-negative red blood cells in maternal circulation, inhibiting production of anti-D 
A)  Attachment of fetal Rh-positive red blood cells in fetal circulation, inhibiting production of anti-D 
B)  Attachment of maternal Rh-negative red blood cells in maternal circulation, inhibiting production of anti-D 
C)  Attachment of fetal Rh-positive red blood cells in maternal circulation, inhibiting production of anti-D 
D)  Attachment of fetal Rh-negative red blood cells in maternal circulation, inhibiting production of anti-D

Question 9

Why is the immediate spin eliminated in the prenatal antibody screen?

Accepted Answer

A)  To reduce the detection of auto-antibodies 
B)  To reduce the detection of IgG antibodies 
C)  To reduce the detection of IgM antibodies 
D)  None of the above 
A)  To reduce the detection of auto-antibodies 
B)  To reduce the detection of IgG antibodies 
C)  To reduce the detection of IgM antibodies 
D)  None of the above

Question 10

Due to a short supply of O-negative packed cells, an Rh-negative patient was transfused with 1 unit of Rh-positive red blood cells. Calculate the number of Rh-immune globulin vials needed to protect against 250 mL of Rh-positive packed cells.

Accepted Answer

A)  5 
B)  17 
C)  10 
D)  23 
A)  5 
B)  17 
C)  10 
D)  23

Question 11

In the event of a clinically significant antibody found in the mother's serum, which of the following must be performed to determine its concentration?

Accepted Answer

A)  Fetal screen 
B)  Antibody screen 
C)  Antibody titer 
D)  Elution 
A)  Fetal screen 
B)  Antibody screen 
C)  Antibody titer 
D)  Elution

Question 12

What physiological phenomenon associates erythroblastosis fetalis with HDFN?

Accepted Answer

A)  Release of nucleated red blood cells (RB
C)  into circulation of mother inflicted with HDFN 
B)  Release of mature RBCs into circulation of neonate inflicted with HDFN 
C)  Release of nucleated RBCs into circulation of neonate inflicted with HDFN 
D)  None of the above 
A)  Release of nucleated red blood cells (RB
C)  into circulation of mother inflicted with HDFN 
B)  Release of mature RBCs into circulation of neonate inflicted with HDFN 
C)  Release of nucleated RBCs into circulation of neonate inflicted with HDFN 
D)  None of the above

Question 13

The most important serologic test for the diagnosis of HDFN is the___________ with anti-IgG reagents.

Accepted Answer

A)  elution 
B)  IAT 
C)  DAT 
D)  fetal screen 
A)  elution 
B)  IAT 
C)  DAT 
D)  fetal screen

Question 14

Why does the rate of RBC destruction after birth decrease in an infant diagnosed with HDFN?

Accepted Answer

A)  Maternal antibody is no longer entering infant circulation via the placenta. 
B)  Reticuloendothelial system of the neonate reaches an equilibrium with the rate of RBC destruction. 
C)  The bone marrow of the neonate compensates for sequestered RBCs. 
D)  None of the above 
A)  Maternal antibody is no longer entering infant circulation via the placenta. 
B)  Reticuloendothelial system of the neonate reaches an equilibrium with the rate of RBC destruction. 
C)  The bone marrow of the neonate compensates for sequestered RBCs. 
D)  None of the above

Question 15

Active immunization induced by Rh(D) antigen can be prevented by the concurrent administration of:

Accepted Answer

A)  gamma globulin. 
B)  Rh immunoglobulin. 
C)  alpha-1 protease inhibitor. 
D)  immune serum globulin. 
A)  gamma globulin. 
B)  Rh immunoglobulin. 
C)  alpha-1 protease inhibitor. 
D)  immune serum globulin.

Question 16

Why is reverse grouping omitted in neonate ABO grouping?

Accepted Answer

A)  Maternal ABO antibody is identical to newborn ABO antibody 
B)  Maternal antibodies mask the ABO antibodies of the neonate 
C)  Newborns do not produce isoagglutinins of their own 
D)  None of the above 
A)  Maternal ABO antibody is identical to newborn ABO antibody 
B)  Maternal antibodies mask the ABO antibodies of the neonate 
C)  Newborns do not produce isoagglutinins of their own 
D)  None of the above

Question 17

An O-positive mother gave birth to an A- negative baby. After 24 hours the newborn's bilirubin level rose to 18 mg/dL. A DAT performed on the cord blood specimen was positive with polyspecific AHG and anti-IgG reagents. It is probable that ___________from maternal circulation is coating the newborn's red blood cells.

Accepted Answer

A)  anti-A, B 
B)  anti-B 
C)  anti-A 
D)  anti-D 
A)  anti-A, B 
B)  anti-B 
C)  anti-A 
D)  anti-D

Question 18

Why is suppression of erythropoiesis an advantage of exchange transfusions?

Accepted Answer

A)  Reduces the production of compatible RBCs 
B)  Reduces the production of incompatible RBCs 
C)  Decreases the risk of iron overload 
D)  Clears nucleated RBCs from circulation 
A)  Reduces the production of compatible RBCs 
B)  Reduces the production of incompatible RBCs 
C)  Decreases the risk of iron overload 
D)  Clears nucleated RBCs from circulation

Question 19

Which of the following treatments uses ultraviolet light to treat hyperbilirubinemia after the infant is delivered?

Accepted Answer

A)  Phototherapy 
B)  Plasma exchange 
C)  Amniocentesis 
D)  Electrophoresis 
A)  Phototherapy 
B)  Plasma exchange 
C)  Amniocentesis 
D)  Electrophoresis

Question 20

A cord blood specimen from a jaundiced infant should be tested for which of the following?

Accepted Answer

A)  ABO 
B)  Rh 
C)  DAT 
D)  All of the above 
A)  ABO 
B)  Rh 
C)  DAT 
D)  All of the above

Exam 19: Hemolytic Disease of the Fetus and Newborn

Which of the following mother/infant blood types would be considered at risk for ABO hemolytic disease of the fetus and newborn?

The antibody titer of maternal antibody is directly proportional to severity of HDFN.

What is done to prevent HDFN caused by maternal anti-Jka antibody formation?

Cannulation of the umbilical vein under ultrasound guidance is known as:

All of the following are characteristic of ABO hemolytic disease of the fetus and newborn (HDFN) except:

When is the antenatal dose of Rh-immune globulin given?

Which IgG subclass carries more potency in red blood cell hemolysis?

What is the physiological mechanism of Rh-immune globulin?

Why is the immediate spin eliminated in the prenatal antibody screen?

Due to a short supply of O-negative packed cells, an Rh-negative patient was transfused with 1 unit of Rh-positive red blood cells. Calculate the number of Rh-immune globulin vials needed to protect against 250 mL of Rh-positive packed cells.

In the event of a clinically significant antibody found in the mother's serum, which of the following must be performed to determine its concentration?

What physiological phenomenon associates erythroblastosis fetalis with HDFN?

The most important serologic test for the diagnosis of HDFN is the___________ with anti-IgG reagents.

Why does the rate of RBC destruction after birth decrease in an infant diagnosed with HDFN?

Active immunization induced by Rh(D) antigen can be prevented by the concurrent administration of:

Why is reverse grouping omitted in neonate ABO grouping?

Why is suppression of erythropoiesis an advantage of exchange transfusions?

Which of the following treatments uses ultraviolet light to treat hyperbilirubinemia after the infant is delivered?

A cord blood specimen from a jaundiced infant should be tested for which of the following?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

What is done to prevent HDFN caused by maternal anti-Jk^a antibody formation?