Question 1

Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?

Accepted Answer

A)  Pentose phosphate shunt 
B)  Luebering-Rapoport shunt 
C)  Glycolysis 
D)  Methemoglobin reductase 
A)  Pentose phosphate shunt 
B)  Luebering-Rapoport shunt 
C)  Glycolysis 
D)  Methemoglobin reductase C

Question 2

What cryoprotective agent is added to red blood cells upon freezing?

Accepted Answer

A)  Dextrose 
B)  Adsol 
C)  Glycerol 
D)  All of the above 
A)  Dextrose 
B)  Adsol 
C)  Glycerol 
D)  All of the above C

Question 3

The normal position of the oxygen dissociation curve depends on three ligands normally found within the RBC. Which one of the following is not one of these ligands?

Accepted Answer

A)  H+ ions 
B)  CO2 
C)  2,3-diphosphoglycerate (2,3-DPG) 
D)  Na+ 
A)  H+ ions 
B)  CO2 
C)  2,3-diphosphoglycerate (2,3-DPG) 
D)  Na+ D

Question 4

What role do platelets play in hemostasis?

Accepted Answer

A)  Maintenance of vascular integrity 
B)  Initial arrest of bleeding by platelet plug formation 
C)  Stabilization of the hemostatic plug 
D)  All of the above 
A)  Maintenance of vascular integrity 
B)  Initial arrest of bleeding by platelet plug formation 
C)  Stabilization of the hemostatic plug 
D)  All of the above

Question 5

Which of the following is a possible future method in pathogen reduction to treat platelet components?

Accepted Answer

A)  UV light and amotosalen 
B)  Amphotericin B 
C)  Vitamin B12 and UV light 
D)  Penicillin 
A)  UV light and amotosalen 
B)  Amphotericin B 
C)  Vitamin B12 and UV light 
D)  Penicillin

Question 6

What is the primary function of hemoglobin?

Accepted Answer

A)  Iron metabolism 
B)  Porphyrin synthesis 
C)  Oxygen transport 
D)  Signal transduction 
A)  Iron metabolism 
B)  Porphyrin synthesis 
C)  Oxygen transport 
D)  Signal transduction

Question 7

Which of the following best describes "integral" membrane proteins?

Accepted Answer

A)  Reside at the cytoplasmic surface of membrane 
B)  Span the entire membrane surface 
C)  Form the red blood cell cytoskeleton 
D)  None of the above 
A)  Reside at the cytoplasmic surface of membrane 
B)  Span the entire membrane surface 
C)  Form the red blood cell cytoskeleton 
D)  None of the above

Question 8

What is the major biochemical consideration in platelet storage?

Accepted Answer

A)  Glucose metabolism 
B)  Oxygen supply 
C)  Production of carbon dioxide 
D)  Regulation of pH 
A)  Glucose metabolism 
B)  Oxygen supply 
C)  Production of carbon dioxide 
D)  Regulation of pH

Question 9

The RBC membrane is relatively permeable to all of the following except:

Accepted Answer

A)  chloride. 
B)  sodium. 
C)  bicarbonate. 
D)  water. 
A)  chloride. 
B)  sodium. 
C)  bicarbonate. 
D)  water.

Question 10

If platelets are to be stored for 5 days on a rotator, what is the optimal storage temperature?

Accepted Answer

A)  1°C to 6°C 
B)  20°C to 24°C 
C)  35°C to 37°C 
D)  1°C to 10°C 
A)  1°C to 6°C 
B)  20°C to 24°C 
C)  35°C to 37°C 
D)  1°C to 10°C

Question 11

Which of the following red blood cell morphologies may be present on the peripheral blood smear as a result of loss of RBC membrane?

Accepted Answer

A)  Spherocytes 
B)  Target cells 
C)  Burr cells 
D)  Schistocytes 
A)  Spherocytes 
B)  Target cells 
C)  Burr cells 
D)  Schistocytes

Question 12

Which of the following is not a commercial system approved by the FDA for screening for bacterial contamination in platelet collections?

Accepted Answer

A)  BacT/ALERT 
B)  eBDS 
C)  BACTEC 
D)  Scansytems 
A)  BacT/ALERT 
B)  eBDS 
C)  BACTEC 
D)  Scansytems

Question 13

In the normal hemoglobin-oxygen dissociation curve, what percentage of oxygen is released to the tissues when PO2 averages 40 mm Hg?

Accepted Answer

A)  75% 
B)  25% 
C)  100% 
D)  50% 
A)  75% 
B)  25% 
C)  100% 
D)  50%

Question 14

What is the average diameter of a platelet?

Accepted Answer

A)  5 to 10 µm 
B)  2 to 4 µm 
C)  1 to 2 µm 
D)  4 to 6 µm 
A)  5 to 10 µm 
B)  2 to 4 µm 
C)  1 to 2 µm 
D)  4 to 6 µm

Question 15

In order to maintain ATP levels in stored blood, _____________can be added to CPD to extend the shelf-life of stored RBCs from 21 days to 35 days. This new preservative is designated as CPDA-1.

Accepted Answer

A)  mannitol 
B)  adenine saline 
C)  adenine and glucose 
D)  Rejuvenix 
A)  mannitol 
B)  adenine saline 
C)  adenine and glucose 
D)  Rejuvenix

Question 16

What does the term autologous transfusion refer to?

Accepted Answer

A)  A parent donating blood for his or her child 
B)  An individual donating blood for a friend 
C)  An individual donating blood for a relative 
D)  An individual donating blood for his or her own transfusion 
A)  A parent donating blood for his or her child 
B)  An individual donating blood for a friend 
C)  An individual donating blood for a relative 
D)  An individual donating blood for his or her own transfusion

Question 17

What is the normal platelet count range per cubic millimeter?

Accepted Answer

A)  100 to 350 
B)  150,000 to 350,000 
C)  50,000 to 200,000 
D)  350,000 to 500,000 
A)  100 to 350 
B)  150,000 to 350,000 
C)  50,000 to 200,000 
D)  350,000 to 500,000

Question 18

What is the normal life span of an RBC?

Accepted Answer

A)  100 days 
B)  120 days 
C)  120 hours 
D)  2 days 
A)  100 days 
B)  120 days 
C)  120 hours 
D)  2 days

Question 19

Which of the following is licensed additive solutions approved for the storage of red blood cells for 42 days?

Accepted Answer

A)  Adsol (AS-1) 
B)  Nutricel (AS-3) 
C)  Optisol (AS-5) 
D)  All of the above 
A)  Adsol (AS-1) 
B)  Nutricel (AS-3) 
C)  Optisol (AS-5) 
D)  All of the above

Question 20

Name the main lipid components of a red blood cell membrane.

Accepted Answer

A)  Phospholipid 
B)  Sphingomyelin 
C)  Glycolipid 
D)  Glycophorin A 
A)  Phospholipid 
B)  Sphingomyelin 
C)  Glycolipid 
D)  Glycophorin A

Exam 1: Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?

What cryoprotective agent is added to red blood cells upon freezing?

The normal position of the oxygen dissociation curve depends on three ligands normally found within the RBC. Which one of the following is not one of these ligands?

What role do platelets play in hemostasis?

Which of the following is a possible future method in pathogen reduction to treat platelet components?

What is the primary function of hemoglobin?

Which of the following best describes "integral" membrane proteins?

What is the major biochemical consideration in platelet storage?

The RBC membrane is relatively permeable to all of the following except:

If platelets are to be stored for 5 days on a rotator, what is the optimal storage temperature?

Which of the following red blood cell morphologies may be present on the peripheral blood smear as a result of loss of RBC membrane?

Which of the following is not a commercial system approved by the FDA for screening for bacterial contamination in platelet collections?

In the normal hemoglobin-oxygen dissociation curve, what percentage of oxygen is released to the tissues when PO2 averages 40 mm Hg?

What is the average diameter of a platelet?

In order to maintain ATP levels in stored blood, _____________can be added to CPD to extend the shelf-life of stored RBCs from 21 days to 35 days. This new preservative is designated as CPDA-1.

What does the term autologous transfusion refer to?

What is the normal platelet count range per cubic millimeter?

What is the normal life span of an RBC?

Which of the following is licensed additive solutions approved for the storage of red blood cells for 42 days?

Name the main lipid components of a red blood cell membrane.

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

In the normal hemoglobin-oxygen dissociation curve, what percentage of oxygen is released to the tissues when PO₂ averages 40 mm Hg?