Question 1

What does Rh genotype refer to?

Accepted Answer

A)  Antigens detected on a red blood cell by serologic methods 
B)  Antibodies detected in serum by serologic methods 
C)  Rh genes inherited from both parents 
D)  Rh genes inherited from the mother 
A)  Antigens detected on a red blood cell by serologic methods 
B)  Antibodies detected in serum by serologic methods 
C)  Rh genes inherited from both parents 
D)  Rh genes inherited from the mother C

Question 2

On which chromosome are the genes that code for RH proteins, namely, RHD and RHCE located?

Accepted Answer

A)  Chromosome 1 
B)  Chromosome 19 
C)  Chromosome 20 
D)  Chromosome 9 
A)  Chromosome 1 
B)  Chromosome 19 
C)  Chromosome 20 
D)  Chromosome 9 A

Question 3

If an individual with a partial D expression is transfused with a normal Rh-positive unit of blood, a likely result will be:

Accepted Answer

A)  the patient will develop an anti-D antibody. 
B)  the patient will form an antibody to the portion of Rh(
D)  protein that they are missing. 
C)  the patient will have an acute hemolytic transfusion reaction. 
D)  the patient will experience no consequence of receiving Rh-positive blood. 
A)  the patient will develop an anti-D antibody. 
B)  the patient will form an antibody to the portion of Rh(
D)  protein that they are missing. 
C)  the patient will have an acute hemolytic transfusion reaction. 
D)  the patient will experience no consequence of receiving Rh-positive blood. B

Question 4

Which of the following statements regarding anti-LW is true?

Accepted Answer

A)  Anti-LW reacts poorly with cord cells. 
B)  Anti-LW reacts stronger with Rh-positive cells than with Rh-negative cells. 
C)  Rh-null individuals lack the LW gene. 
D)  The gene coding for LW is located on the same chromosome as the Rh genes. 
A)  Anti-LW reacts poorly with cord cells. 
B)  Anti-LW reacts stronger with Rh-positive cells than with Rh-negative cells. 
C)  Rh-null individuals lack the LW gene. 
D)  The gene coding for LW is located on the same chromosome as the Rh genes.

Question 5

The Rh antibody agglutinates what percentage of RBCs?

Accepted Answer

A)  15% 
B)  85% 
C)  50% 
D)  35% 
A)  15% 
B)  85% 
C)  50% 
D)  35%

Question 6

The Rh testing on a blood donor was negative at immediate spin. The tube was incubated at 37°C for 15 minutes. The tube was centrifuged and read macroscopically. The test was negative at 37°C. The tube was washed three times with saline, and two drops of AHG were added. After centrifugation, the tube yielded a 2+ reaction. How is this Rh type reported on the donor unit?

Accepted Answer

A)  Rh-positive 
B)  Rh-negative 
C)  Du-positive 
D)  Rh-variable 
A)  Rh-positive 
B)  Rh-negative 
C)  Du-positive 
D)  Rh-variable

Question 7

Why do false-negative Rh testing results occur in babies with severe hemolytic disease of the newborn due to anti-D?

Accepted Answer

A)  The cord cells may be contaminated with Wharton's jelly. 
B)  All D sites are covered by maternal anti-D, which blocks the reagent. 
C)  Antigens are not expressed yet. 
D)  None of the above 
A)  The cord cells may be contaminated with Wharton's jelly. 
B)  All D sites are covered by maternal anti-D, which blocks the reagent. 
C)  Antigens are not expressed yet. 
D)  None of the above

Question 8

Why is determination of Rh status crucial for obstetric patients?

Accepted Answer

A)  An Rh-positive mother can form anti-D, which will destroy D-positive red blood cells of the fetus. 
B)  All Rh-positive mothers are possible candidates for Rh immune globulin. 
C)  All Rh-negative mothers are possible candidates for Rh immune globulin. 
D)  An Rh-negative mother can form anti-D if she gives birth to an Rh-negative baby. 
A)  An Rh-positive mother can form anti-D, which will destroy D-positive red blood cells of the fetus. 
B)  All Rh-positive mothers are possible candidates for Rh immune globulin. 
C)  All Rh-negative mothers are possible candidates for Rh immune globulin. 
D)  An Rh-negative mother can form anti-D if she gives birth to an Rh-negative baby.

Question 9

How are the Rh antigens inherited?

Accepted Answer

A)  X-linked recessive 
B)  Codominant alleles 
C)  X-linked dominant 
D)  None of the above 
A)  X-linked recessive 
B)  Codominant alleles 
C)  X-linked dominant 
D)  None of the above

Question 10

Which antigen represents Rh3 in Rosenfield terminology?

Accepted Answer

A)  D 
B)  E 
C)  C 
D)  e 
A)  D 
B)  E 
C)  C 
D)  e

Question 11

A male patient was seen in the emergency room with an acute bleed. The recommendation from the blood supplier is to give O-positive RBCs as uncrossmatched blood. This patient has already been exposed to Rh-positive blood after a previous accident. What is a possible outcome?

Accepted Answer

A)  The patient may have a hemolytic transfusion reaction from an allo immunized anti-D. 
B)  Anti-D is not immunogenic, and the patient probably would not have formed an anti-D. 
C)  Anti-D is not hemolytic, and even with the circulating antibody there would be no danger to the patient. 
D)  The anti-D would activate complement, and a strong intravascular transfusion reaction would occur. 
A)  The patient may have a hemolytic transfusion reaction from an allo immunized anti-D. 
B)  Anti-D is not immunogenic, and the patient probably would not have formed an anti-D. 
C)  Anti-D is not hemolytic, and even with the circulating antibody there would be no danger to the patient. 
D)  The anti-D would activate complement, and a strong intravascular transfusion reaction would occur.

Question 12

When one or more D epitopes within the entire D protein is missing it is termed_______________.

Accepted Answer

A)  weak D 
B)  C in trans to Rh(
D)  
C)  Del 
D)  partial D 
A)  weak D 
B)  C in trans to Rh(
D)  
C)  Del 
D)  partial D

Question 13

An individuals of the dce/dce genotype given dCe/dce blood has an antibody response that appears to be anti-C and anti-D. The most likely explanation for this is:

Accepted Answer

A)  The antibody is anti-G. 
B)  The antibody is anti-partial D. 
C)  The antibody is anti-Cw. 
D)  There was an incorrect reading of the agglutination reactions. 
A)  The antibody is anti-G. 
B)  The antibody is anti-partial D. 
C)  The antibody is anti-Cw. 
D)  There was an incorrect reading of the agglutination reactions.

Question 14

G antigen is present on all of which type of red blood cells?

Accepted Answer

A)  D-positive 
B)  C-positive 
C)  E-positive 
D)  e-positive 
A)  D-positive 
B)  C-positive 
C)  E-positive 
D)  e-positive

Question 15

Which of the following genotypes would demonstrate the strongest expression of D antigen?

Accepted Answer

A)  Dce/dCE 
B)  DCe/dce 
C)  dce/dce 
D)  dCe/dcE 
A)  Dce/dCE 
B)  DCe/dce 
C)  dce/dce 
D)  dCe/dcE

Question 16

What are the dangers of transfusing donor Rh-negative RBCs to an Rh-positive patient?

Accepted Answer

A)  There are no dangers. 
B)  A hemolytic transfusion reaction will occur. 
C)  A patient will be sensitized and will develop an Anti-D. 
D)  Most Rh-negative blood is c- and e-positive, and because of their immunogenicity the patient may form an antibody to those antigens. 
A)  There are no dangers. 
B)  A hemolytic transfusion reaction will occur. 
C)  A patient will be sensitized and will develop an Anti-D. 
D)  Most Rh-negative blood is c- and e-positive, and because of their immunogenicity the patient may form an antibody to those antigens.

Question 17

All of the following are true regarding Rh antibodies except:

Accepted Answer

A)  Rh antibodies can bind complement on the red blood cell membrane. 
B)  An individual with a low titer Rh antibody may experience a secondary immune response on antigen exposure. 
C)  Rh antibodies may cause a delayed hemolytic transfusion reaction. 
D)  Red blood cell destruction is usually extravascular. 
A)  Rh antibodies can bind complement on the red blood cell membrane. 
B)  An individual with a low titer Rh antibody may experience a secondary immune response on antigen exposure. 
C)  Rh antibodies may cause a delayed hemolytic transfusion reaction. 
D)  Red blood cell destruction is usually extravascular.

Question 18

Of the three following categories of altered D antigen, in which variation of D antigen expression are you more likely to encounter an allo-anti-D?

Accepted Answer

A)  C in Trans to RhD 
B)  Weak D 
C)  Partial D 
D)  None of the above 
A)  C in Trans to RhD 
B)  Weak D 
C)  Partial D 
D)  None of the above

Question 19

What does hr' refer to in the Weiner nomenclature?

Accepted Answer

A)  c 
B)  e 
C)  C 
D)  E 
A)  c 
B)  e 
C)  C 
D)  E

Question 20

Rh-immune globulin is effective is preventing which type of hemolytic disease of the newborn (HDN)?

Accepted Answer

A)  Anti-c 
B)  Anti-E 
C)  Anti-D 
D)  Anti-C 
A)  Anti-c 
B)  Anti-E 
C)  Anti-D 
D)  Anti-C

Exam 7: The RH Blood Group System

What does Rh genotype refer to?

On which chromosome are the genes that code for RH proteins, namely, RHD and RHCE located?

If an individual with a partial D expression is transfused with a normal Rh-positive unit of blood, a likely result will be:

Which of the following statements regarding anti-LW is true?

The Rh antibody agglutinates what percentage of RBCs?

Why do false-negative Rh testing results occur in babies with severe hemolytic disease of the newborn due to anti-D?

Why is determination of Rh status crucial for obstetric patients?

How are the Rh antigens inherited?

Which antigen represents Rh3 in Rosenfield terminology?

A male patient was seen in the emergency room with an acute bleed. The recommendation from the blood supplier is to give O-positive RBCs as uncrossmatched blood. This patient has already been exposed to Rh-positive blood after a previous accident. What is a possible outcome?

When one or more D epitopes within the entire D protein is missing it is termed_______________.

An individuals of the dce/dce genotype given dCe/dce blood has an antibody response that appears to be anti-C and anti-D. The most likely explanation for this is:

G antigen is present on all of which type of red blood cells?

Which of the following genotypes would demonstrate the strongest expression of D antigen?

What are the dangers of transfusing donor Rh-negative RBCs to an Rh-positive patient?

All of the following are true regarding Rh antibodies except:

Of the three following categories of altered D antigen, in which variation of D antigen expression are you more likely to encounter an allo-anti-D?

What does hr' refer to in the Weiner nomenclature?

Rh-immune globulin is effective is preventing which type of hemolytic disease of the newborn (HDN)?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

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