Question 1

What does the term exalted D refer to?

Accepted Answer

A)  Deletion of the D antigen 
B)  Stronger expression of Cc antigens when D is missing 
C)  Stronger expression of Ee antigens when D is missing 
D)  Stronger expression of D antigens when Cc and Ee are missing 
A)  Deletion of the D antigen 
B)  Stronger expression of Cc antigens when D is missing 
C)  Stronger expression of Ee antigens when D is missing 
D)  Stronger expression of D antigens when Cc and Ee are missing

Question 2

What is the frequency of E antigen in the general population?

Accepted Answer

A)  85% 
B)  15% 
C)  98% 
D)  30% 
A)  85% 
B)  15% 
C)  98% 
D)  30%

Question 3

What is an advantage of using chemically modified anti-D?

Accepted Answer

A)  It provides a low-protein medium. 
B)  Rh control is not necessary. 
C)  Few false-negative results are obtained. 
D)  Du testing is eliminated. 
A)  It provides a low-protein medium. 
B)  Rh control is not necessary. 
C)  Few false-negative results are obtained. 
D)  Du testing is eliminated.

Question 4

Which of the following genotypes is consistent with f antigen expression?

Accepted Answer

A)  DcE/DCe 
B)  Dce/DCE 
C)  DCe/DcE 
D)  DCe/dCE 
A)  DcE/DCe 
B)  Dce/DCE 
C)  DCe/DcE 
D)  DCe/dCE

Question 5

What clinical manifestation may be associated with the Rh-null syndrome?

Accepted Answer

A)  Reticulocytosis 
B)  Stomatocytosis 
C)  Low hemoglobin 
D)  All of the above 
A)  Reticulocytosis 
B)  Stomatocytosis 
C)  Low hemoglobin 
D)  All of the above

Question 6

Why must there be alpha designations in the Rosenfield system?

Accepted Answer

A)  Nomenclature applies to other blood group systems besides Rh. 
B)  Rosenfield nomenclature is only used in the Rh blood system. 
C)  Weiner and Fisher-Race use alpha designations. 
D)  None of the above 
A)  Nomenclature applies to other blood group systems besides Rh. 
B)  Rosenfield nomenclature is only used in the Rh blood system. 
C)  Weiner and Fisher-Race use alpha designations. 
D)  None of the above

Question 7

A cord blood sample was sent to the blood bank for a type and DAT. Cells were washed six times with saline before testing. The forward grouping typed as an O. There was no agglutination with anti-D and washed cord cells. The DAT was 3+ with polyspecific AHG. What is the Rh type of the baby?

Accepted Answer

A)  Rh-negative 
B)  Rh-positive 
C)  Rh type cannot be determined 
D)  None of the above 
A)  Rh-negative 
B)  Rh-positive 
C)  Rh type cannot be determined 
D)  None of the above

Question 8

Most Rh antibodies are of what immunoglobulin class?

Accepted Answer

A)  IgM 
B)  IgG 
C)  IgA 
D)  IgE 
A)  IgM 
B)  IgG 
C)  IgA 
D)  IgE

Question 9

What protocol is put in place to validate Rh testing when high-protein reagents are used, especially when the patient types as an AB-positive?

Accepted Answer

A)  Wash cells before testing 
B)  Run a control with Rh test 
C)  Add LISS to test system 
D)  Use only saline reactive anti-D 
A)  Wash cells before testing 
B)  Run a control with Rh test 
C)  Add LISS to test system 
D)  Use only saline reactive anti-D

Question 10

In which population is the genetic Du usually found?

Accepted Answer

A)  White 
B)  Asian 
C)  Black 
D)  Native American 
A)  White 
B)  Asian 
C)  Black 
D)  Native American

Question 11

All of the following may cause a false-negative reaction in Rh typing except:

Accepted Answer

A)  omission of reagent. 
B)  immunoglobulin coating cells. 
C)  rouleaux. 
D)  cell suspension that is too heavy. 
A)  omission of reagent. 
B)  immunoglobulin coating cells. 
C)  rouleaux. 
D)  cell suspension that is too heavy.

Question 12

What does the "R" represent in Rh-Hr terminology?

Accepted Answer

A)  Absence of D antigen 
B)  Presence of D antigen 
C)  Presence of C antigen 
D)  Presence of e antigen 
A)  Absence of D antigen 
B)  Presence of D antigen 
C)  Presence of C antigen 
D)  Presence of e antigen

Question 13

The biochemical structure of the Rh antigens is a nonglycosylated protein, meaning:

Accepted Answer

A)  lipids are not attached to protein structure. 
B)  carbohydrates are not attached to protein structure. 
C)  glucose is attached to protein. 
D)  glycerol is attached to protein. 
A)  lipids are not attached to protein structure. 
B)  carbohydrates are not attached to protein structure. 
C)  glucose is attached to protein. 
D)  glycerol is attached to protein.

Question 14

All of the following are consistent with International Society of Blood Transfusion (ISBT) terminology except:

Accepted Answer

A)  A six-digit number specifies each blood group antigen. 
B)  004 represents Rh group. 
C)  D is written as "R1." 
D)  All genes are written in bold print. 
A)  A six-digit number specifies each blood group antigen. 
B)  004 represents Rh group. 
C)  D is written as "R1." 
D)  All genes are written in bold print.

Question 15

Which of the following reagents or methods is best for categorizing partial D types?

Accepted Answer

A)  Saline based anti-D 
B)  High protein anti-D 
C)  A combination of serological typing and molecular analysis 
D)  Monoclonal anti-D reagents 
A)  Saline based anti-D 
B)  High protein anti-D 
C)  A combination of serological typing and molecular analysis 
D)  Monoclonal anti-D reagents

Question 16

Anti-LW will react most strongly with:

Accepted Answer

A)  adult Rh-positive RBCs. 
B)  Rh-negative RBCs. 
C)  Rh-null RBCs. 
D)  Rh-negative cord blood. 
A)  adult Rh-positive RBCs. 
B)  Rh-negative RBCs. 
C)  Rh-null RBCs. 
D)  Rh-negative cord blood.

Question 17

Where is the Rh antigen located relative to the red blood cell membrane?

Accepted Answer

A)  Integrally 
B)  Peripherally 
C)  Centrally 
D)  None of the above 
A)  Integrally 
B)  Peripherally 
C)  Centrally 
D)  None of the above

Question 18

When a patient has Rh-null syndrome, what kind of packed RBCs need to be transfused?

Accepted Answer

A)  ABO compatible Rh-positive blood 
B)  ABO compatible Rh-negative blood 
C)  ABO compatible Rh-null blood 
D)  O-negative PRBCs 
A)  ABO compatible Rh-positive blood 
B)  ABO compatible Rh-negative blood 
C)  ABO compatible Rh-null blood 
D)  O-negative PRBCs

Question 19

Which of the following Rh antigens is the most immunogenic?

Accepted Answer

A)  D 
B)  C 
C)  e 
D)  E 
A)  D 
B)  C 
C)  e 
D)  E

Question 20

The Rh gene is located on which chromosome?

Accepted Answer

A)  1 
B)  7 
C)  9 
D)  11 
A)  1 
B)  7 
C)  9 
D)  11

Exam 7: The RH Blood Group System

What does the term exalted D refer to?

What is the frequency of E antigen in the general population?

What is an advantage of using chemically modified anti-D?

Which of the following genotypes is consistent with f antigen expression?

What clinical manifestation may be associated with the Rh-null syndrome?

Why must there be alpha designations in the Rosenfield system?

A cord blood sample was sent to the blood bank for a type and DAT. Cells were washed six times with saline before testing. The forward grouping typed as an O. There was no agglutination with anti-D and washed cord cells. The DAT was 3+ with polyspecific AHG. What is the Rh type of the baby?

Most Rh antibodies are of what immunoglobulin class?

What protocol is put in place to validate Rh testing when high-protein reagents are used, especially when the patient types as an AB-positive?

In which population is the genetic Du usually found?

All of the following may cause a false-negative reaction in Rh typing except:

What does the "R" represent in Rh-Hr terminology?

The biochemical structure of the Rh antigens is a nonglycosylated protein, meaning:

All of the following are consistent with International Society of Blood Transfusion (ISBT) terminology except:

Which of the following reagents or methods is best for categorizing partial D types?

Anti-LW will react most strongly with:

Where is the Rh antigen located relative to the red blood cell membrane?

When a patient has Rh-null syndrome, what kind of packed RBCs need to be transfused?

Which of the following Rh antigens is the most immunogenic?

The Rh gene is located on which chromosome?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

When a patient has Rh-nullsyndrome, what kind of packed RBCs need to be transfused?