Question 1

Which of the following reagents can be used to determine the immunoglobulin class of anti-M?

Accepted Answer

A)  PEG 
B)  Chloroquine 
C)  2-mercaptoethanol 
D)  Ficin 
A)  PEG 
B)  Chloroquine 
C)  2-mercaptoethanol 
D)  Ficin

Question 2

All of the following are true regarding antibody titration of maternal IgG antibodies except:

Accepted Answer

A)  the method must include the indirect antiglobulin test. 
B)  the difference of two or more dilutions between titrations is considered significant. 
C)  red blood cells should consist of the same genotype for each titration. 
D)  the first serum specimen should be run in parallel with all subsequent titrations. 
A)  the method must include the indirect antiglobulin test. 
B)  the difference of two or more dilutions between titrations is considered significant. 
C)  red blood cells should consist of the same genotype for each titration. 
D)  the first serum specimen should be run in parallel with all subsequent titrations.

Question 3

Rh-immune globulin is of no benefit after a person has been actively immunized and formed anti-D.

Accepted Answer

A) True 
 B)False

Question 4

Which red blood cell morphology is most characteristic in ABO HDFN and absent in Rh HDFN?

Accepted Answer

A)  Target cells 
B)  Teardrop cells 
C)  Microspherocytes 
D)  Burr cells 
A)  Target cells 
B)  Teardrop cells 
C)  Microspherocytes 
D)  Burr cells

Question 5

All Rh-negative recipients who are transfused with as little as 1 mL of Rh-positive cells will develop anti-D.

Accepted Answer

A) True 
 B)False

Question 6

What is the cause of HDFN?

Accepted Answer

A)  Destruction of the mother's RBCs by autoantibody 
B)  Destruction of the fetus's RBCs by antibody produced by the mother 
C)  Destruction of the fetus's RBCs by autoantibody 
D)  Destruction of the mother's RBCs by antibody produced by the fetus 
A)  Destruction of the mother's RBCs by autoantibody 
B)  Destruction of the fetus's RBCs by antibody produced by the mother 
C)  Destruction of the fetus's RBCs by autoantibody 
D)  Destruction of the mother's RBCs by antibody produced by the fetus

Question 7

Anti-D in the serum of a third trimester pregnant woman with a titer of 16 is indicative of:

Accepted Answer

A)  Rh-immune globulin. 
B)  active immunization. 
C)  passive immunization. 
D)  none of the above. 
A)  Rh-immune globulin. 
B)  active immunization. 
C)  passive immunization. 
D)  none of the above.

Question 8

How are units for exchange transfusion prepared?

Accepted Answer

A)  Group O red blood cells and group O plasma 
B)  Group O red blood cells and group A plasma 
C)  Group O red blood cells and group AB plasma 
D)  Group O red blood cells and group B plasma 
A)  Group O red blood cells and group O plasma 
B)  Group O red blood cells and group A plasma 
C)  Group O red blood cells and group AB plasma 
D)  Group O red blood cells and group B plasma

Question 9

Which of the following antibodies have not been known to cause HDFN?

Accepted Answer

A)  Anti-C 
B)  Anti-S 
C)  Anti-D 
D)  Anti-Lea 
A)  Anti-C 
B)  Anti-S 
C)  Anti-D 
D)  Anti-Lea

Question 10

What immunoglobulin is capable of crossing the placenta?

Accepted Answer

A)  IgG 
B)  IgM 
C)  IgA 
D)  All of the above 
A)  IgG 
B)  IgM 
C)  IgA 
D)  All of the above

Question 11

In HDFN, the IgG antibodies are directed against which antigen on the fetal red blood cells?

Accepted Answer

A)  Maternal 
B)  Paternal 
C)  Bacterial 
D)  Viral 
A)  Maternal 
B)  Paternal 
C)  Bacterial 
D)  Viral

Question 12

The laboratory is presented with a case of HDFN due to ABO incompatibility. The mother is Group O and the infant is Group B. The most appropriate type of blood to use for an exchange transfusion for this infant is:

Accepted Answer

A)  A 
B)  B 
C)  O 
D)  AB 
A)  A 
B)  B 
C)  O 
D)  AB

Question 13

How is an intrauterine transfusion performed?

Accepted Answer

A)  RBCs are injected into the placenta. 
B)  RBCs are injected into the fetal peritoneal cavity. 
C)  RBCs are injected into the maternal peritoneal cavity. 
D)  RBCs are injected into the mother and diffused through the placenta to the fetus. 
A)  RBCs are injected into the placenta. 
B)  RBCs are injected into the fetal peritoneal cavity. 
C)  RBCs are injected into the maternal peritoneal cavity. 
D)  RBCs are injected into the mother and diffused through the placenta to the fetus.

Question 14

Besides the Rh antibodies, what other red blood cell antibody is common to cause severe HDFN?

Accepted Answer

A)  Anti-M 
B)  Anti-Lea 
C)  Anti-K 
D)  Anti-Fyb 
A)  Anti-M 
B)  Anti-Lea 
C)  Anti-K 
D)  Anti-Fyb

Question 15

What life-threatening disorder is characterized by a severe anemia, effusions, and ascites from hepatomegaly and splenomegaly?

Accepted Answer

A)  Thalassemia 
B)  Sickle cell anemia 
C)  Hereditary persistence of fetal hemoglobin 
D)  Hydrops fetalis 
A)  Thalassemia 
B)  Sickle cell anemia 
C)  Hereditary persistence of fetal hemoglobin 
D)  Hydrops fetalis

Exam 19: Hemolytic Disease of the Fetus and Newborn

Which of the following reagents can be used to determine the immunoglobulin class of anti-M?

All of the following are true regarding antibody titration of maternal IgG antibodies except:

Rh-immune globulin is of no benefit after a person has been actively immunized and formed anti-D.

Which red blood cell morphology is most characteristic in ABO HDFN and absent in Rh HDFN?

All Rh-negative recipients who are transfused with as little as 1 mL of Rh-positive cells will develop anti-D.

What is the cause of HDFN?

Anti-D in the serum of a third trimester pregnant woman with a titer of 16 is indicative of:

How are units for exchange transfusion prepared?

Which of the following antibodies have not been known to cause HDFN?

What immunoglobulin is capable of crossing the placenta?

In HDFN, the IgG antibodies are directed against which antigen on the fetal red blood cells?

The laboratory is presented with a case of HDFN due to ABO incompatibility. The mother is Group O and the infant is Group B. The most appropriate type of blood to use for an exchange transfusion for this infant is:

How is an intrauterine transfusion performed?

Besides the Rh antibodies, what other red blood cell antibody is common to cause severe HDFN?

What life-threatening disorder is characterized by a severe anemia, effusions, and ascites from hepatomegaly and splenomegaly?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters