Exam 17: Cellular Therapy

A 41-year-old multiparous woman was rushed to the emergency room after being shot in the chest. She received 8 units of packed red blood cells and 5 units of platelets. The hemoglobin and hematocrit determinations stabilized after 6 hours in surgery, but the platelet counts remained less than 50,000 per µL. She had received additional units of platelets at 48-hour intervals with little efficacy. Her serum was tested for platelet antibodies. She was placed on corticosteroids to control chest wound bleeding. Anti-PL^A1 was identified in the patient's serum. This case is representative of what type of transfusion reaction?

An identical twin donating to its twin sibling is an example of what kind of hematopoietic progenitor cell donation?

A delta check was noted for potassium after a surgical patient was transfused with 2 units of packed red blood cells. The pre-transfusion potassium was 3.1 mmol/L and the post-transfusion specimen was 6.2 mmol/L. What could be the reason for this sudden increase?

Which of the following is not a finding associated with intravascular hemolytic reaction?

Which of the following should be collected immediately from a patient exhibiting signs of a septic reaction to blood products?

A transfusion reaction investigation should include all of the following except:

A patient with two or more documented febrile nonhemolytic transfusion reactions (FNHTRs) should receive_____ blood components.

Which of the following therapies is not advocated in circulatory overload?

How can depletion and dilution of coagulation factors be avoided in a massively transfused patient?

Which of the following can be added to blood prior to or during transfusion?

Which of the following statements is false?

What is the length of time required for production of antibody in a DHTR caused by an anamnestic immune response?

What would be the result of group B blood given to a group O patient?

A severe manifestation of alloimmunization might include:

Which of the following is indicative of GVHD?

Which of the following products may lead to sepsis in a patient when contaminated with Escherichia coli?

Why is an FNHTR said to be a "diagnosis of exclusion"?

A patient undergoing transfusion of packed red blood cells became hypotensive and cyanotic 30 minutes into the transfusion. The nurse also noted a 0.8°C increase in temperature. The transfusion was stopped and post-blood specimens were sent down to the laboratory for a transfusion reaction investigation. The donor serum was tested against screening cells (3-vials) and was reactive at AHG in all vials. A panel was performed, and anti-Bg^a was identified. What special blood component should this patient now receive?

In a DHTR, patient antibody attaches to the specific foreign donor red blood cell antigen, causing sensitization of red blood cells, which are removed by the:

Physical or chemical damage of the transfused red blood cells can result in: