Question 1

Where are the P antigens found?

Accepted Answer

A)  Red blood cells 
B)  Platelets 
C)  Tissue fibroblasts 
D)  All of the above 
A)  Red blood cells 
B)  Platelets 
C)  Tissue fibroblasts 
D)  All of the above

Question 2

How do MN antigens differ in their biochemical protein structure?

Accepted Answer

A)  M contains serine at position 1 and N contains glycine. 
B)  N contains glutamic acid at position 5 and M contains glycine. 
C)  N contains glycine at position 5 and M contains arginine. 
D)  M contains serine at position 1 and N contains lysine. 
A)  M contains serine at position 1 and N contains glycine. 
B)  N contains glutamic acid at position 5 and M contains glycine. 
C)  N contains glycine at position 5 and M contains arginine. 
D)  M contains serine at position 1 and N contains lysine.

Question 3

Anti-N will react stronger with which phenotype?

Accepted Answer

A)  M+N+ 
B)  M-N+ 
C)  M+N- 
D)  M-N- 
A)  M+N+ 
B)  M-N+ 
C)  M+N- 
D)  M-N-

Question 4

A patient presented in the emergency room needing to be transfused ASAP. According to the computer, the patient had a Kell antibody five years ago. The antibody screen is negative now. Of the following, the best procedure to obtain suitable blood for transfusion is:

Accepted Answer

A)  to use immediate spin crossmatch compatible blood. 
B)  to take the time to crossmatch the units of blood through the AHG phase. 
C)  to antigen type the units for Kell and completely crossmatch the negative ones. 
D)  to assume the electronic crossmatch is acceptable. 
A)  to use immediate spin crossmatch compatible blood. 
B)  to take the time to crossmatch the units of blood through the AHG phase. 
C)  to antigen type the units for Kell and completely crossmatch the negative ones. 
D)  to assume the electronic crossmatch is acceptable.

Question 5

The seven Gerbich antigens are located on:

Accepted Answer

A)  glycophorins A and B. 
B)  glycophorins C and D. 
C)  glycophorins A and D. 
D)  glycophorins B and C. 
A)  glycophorins A and B. 
B)  glycophorins C and D. 
C)  glycophorins A and D. 
D)  glycophorins B and C.

Question 6

Which of the following is not involved in the Kell blood group system?

Accepted Answer

A)  Jsa 
B)  K 
C)  Kpb 
D)  Jka 
A)  Jsa 
B)  K 
C)  Kpb 
D)  Jka

Question 7

The rarely encountered Scianna antibodies react in which phase of the antibody screen?

Accepted Answer

A)  Immediate spin 
B)  37°C 
C)  AHG 
D)  All of the above 
A)  Immediate spin 
B)  37°C 
C)  AHG 
D)  All of the above

Question 8

The mating of an Xg+ man with an Xg- woman would produce a son with what phenotype?

Accepted Answer

A)  Xg(a+) 
B)  Xg(a-) 
C)  All of the above 
D)  None of the above 
A)  Xg(a+) 
B)  Xg(a-) 
C)  All of the above 
D)  None of the above

Question 9

A woman came in for a cesarean section. The antibody screen was positive with a 3+ reaction in the AHG phase using screening cell I. Screening cells II and III were negative in all phases. An 8-cell panel was performed that paralleled the antibody screen, where three cells reacted 3+ at AHG and five cells were negative at all phases of reactivity. The antibody identified was anti-Kell. What procedure might be helpful in predicting the infant's susceptibility to HDN?

Accepted Answer

A)  Determination of the mother's phenotype 
B)  Determination of the father's phenotype 
C)  Plasmapheresis of the mother's plasma 
D)  A fetal screen (rosette test) on the mother 
A)  Determination of the mother's phenotype 
B)  Determination of the father's phenotype 
C)  Plasmapheresis of the mother's plasma 
D)  A fetal screen (rosette test) on the mother

Question 10

All of the following are characteristics of Duffy antibodies except:

Accepted Answer

A)  they are IgG in nature. 
B)  they may or may not show dosage. 
C)  they are destroyed by enzymes. 
D)  they are not implicated in HDN. 
A)  they are IgG in nature. 
B)  they may or may not show dosage. 
C)  they are destroyed by enzymes. 
D)  they are not implicated in HDN.

Question 11

At what age does I antigen become detectable on infant cells?

Accepted Answer

A)  1 year 
B)  18 months 
C)  4 years 
D)  1 month 
A)  1 year 
B)  18 months 
C)  4 years 
D)  1 month

Question 12

Autoantibodies to U antigen may be found in patients with:

Accepted Answer

A)  paroxysmal cold hemoglobinuria. 
B)  cold autoimmune hemolytic anemia. 
C)  warm autoimmune hemolytic anemia. 
D)  drug-induced hemolytic anemia. 
A)  paroxysmal cold hemoglobinuria. 
B)  cold autoimmune hemolytic anemia. 
C)  warm autoimmune hemolytic anemia. 
D)  drug-induced hemolytic anemia.

Question 13

Why is it strongly recommended that only homozygous cells be used when ruling out Kidd antibodies?

Accepted Answer

A)  Anti-Jka may appear compatible with homozygous cells [Jk(a+b-)]. 
B)  Anti-Jka may appear compatible with heterozygous cells [Jk(a+b+)]. 
C)  It will reduce the number of false-positive results. 
D)  Options A and C 
A)  Anti-Jka may appear compatible with homozygous cells [Jk(a+b-)]. 
B)  Anti-Jka may appear compatible with heterozygous cells [Jk(a+b+)]. 
C)  It will reduce the number of false-positive results. 
D)  Options A and C

Question 14

Which has been shown to define the Duffy receptor that Plasmodium vivax uses to penetrate red blood cells?

Accepted Answer

A)  Anti-Fy3 
B)  Anti-Fy5 
C)  Anti-Fy6 
D)  Anti-Fy4 
A)  Anti-Fy3 
B)  Anti-Fy5 
C)  Anti-Fy6 
D)  Anti-Fy4

Question 15

Patients diagnosed with_______________ , where the autoantibody is directed against the K antigen, may exhibit a diminished expression of antigen.

Accepted Answer

A)  autoimmune hemolytic anemia 
B)  lupus erythematosus 
C)  rheumatoid arthritis 
D)  chronic granulomatous disease 
A)  autoimmune hemolytic anemia 
B)  lupus erythematosus 
C)  rheumatoid arthritis 
D)  chronic granulomatous disease

Question 16

How does complement aid in the identification of alloantibodies masked by anti-Cha?

Accepted Answer

A)  C4d in plasma will absorb anti-Cha. 
B)  C3b in serum will absorb anti-Cha. 
C)  C3d in plasma will absorb anti-Cha. 
D)  C4a in plasma will absorb anti-Cha. 
A)  C4d in plasma will absorb anti-Cha. 
B)  C3b in serum will absorb anti-Cha. 
C)  C3d in plasma will absorb anti-Cha. 
D)  C4a in plasma will absorb anti-Cha.

Question 17

Type I H antigen in secretions is a product of which of the following genes?

Accepted Answer

A)  H 
B)  Le 
C)  Se 
D)  le 
A)  H 
B)  Le 
C)  Se 
D)  le

Question 18

All of the following characteristics regarding the Kell antigen are true except:

Accepted Answer

A)  it is well-developed at birth. 
B)  it exhibits dosage. 
C)  it is destroyed by ficin treatment. 
D)  it is strongly immunogenic. 
A)  it is well-developed at birth. 
B)  it exhibits dosage. 
C)  it is destroyed by ficin treatment. 
D)  it is strongly immunogenic.

Question 19

All of the following are characteristic of anti-P1 except:

Accepted Answer

A)  the antibody is IgM. 
B)  the antibody reacts strongly at room temperature. 
C)  the antibody is not neutralized by soluble P1 substance. 
D)  the antibody may be detected in AHG phase of antiglobulin test if polyspecific antiserum is used. 
A)  the antibody is IgM. 
B)  the antibody reacts strongly at room temperature. 
C)  the antibody is not neutralized by soluble P1 substance. 
D)  the antibody may be detected in AHG phase of antiglobulin test if polyspecific antiserum is used.

Question 20

Persons who inherit the In(Lu) gene will exhibit:

Accepted Answer

A)  Jk(a-b+) red blood cells that can elute anti-Jk3. 
B)  Jk(a+b-) red blood cells that can elute anti-Jka. 
C)  Jk(a+b-) red blood cells that can absorb anti-Jk3. 
D)  Jk(a-b-) red blood cells that can absorb anti-Jka. 
A)  Jk(a-b+) red blood cells that can elute anti-Jk3. 
B)  Jk(a+b-) red blood cells that can elute anti-Jka. 
C)  Jk(a+b-) red blood cells that can absorb anti-Jk3. 
D)  Jk(a-b-) red blood cells that can absorb anti-Jka.

Exam 8: Blood Group Terminology and the Other Blood Groups

Where are the P antigens found?

How do MN antigens differ in their biochemical protein structure?

Anti-N will react stronger with which phenotype?

A patient presented in the emergency room needing to be transfused ASAP. According to the computer, the patient had a Kell antibody five years ago. The antibody screen is negative now. Of the following, the best procedure to obtain suitable blood for transfusion is:

The seven Gerbich antigens are located on:

Which of the following is not involved in the Kell blood group system?

The rarely encountered Scianna antibodies react in which phase of the antibody screen?

The mating of an Xg+ man with an Xg- woman would produce a son with what phenotype?

All of the following are characteristics of Duffy antibodies except:

At what age does I antigen become detectable on infant cells?

Autoantibodies to U antigen may be found in patients with:

Why is it strongly recommended that only homozygous cells be used when ruling out Kidd antibodies?

Which has been shown to define the Duffy receptor that Plasmodium vivax uses to penetrate red blood cells?

Patients diagnosed with_______________ , where the autoantibody is directed against the K antigen, may exhibit a diminished expression of antigen.

How does complement aid in the identification of alloantibodies masked by anti-Cha?

Type I H antigen in secretions is a product of which of the following genes?

All of the following characteristics regarding the Kell antigen are true except:

All of the following are characteristic of anti-P1 except:

Persons who inherit the In(Lu) gene will exhibit:

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

How does complement aid in the identification of alloantibodies masked by anti-Ch^a?

All of the following are characteristic of anti-P₁ except: