Question 1

Which group of antigens below best represents the definition of high-frequency antigens?

Accepted Answer

A)  Jsb, Kpb 
B)  K, k 
C)  Kpa, Jsa 
D)  Jka, K 
A)  Jsb, Kpb 
B)  K, k 
C)  Kpa, Jsa 
D)  Jka, K

Question 2

Why is HDN not a consideration when the mother possesses anti-P1 in her serum?

Accepted Answer

A)  Anti-P1 is an IgM antibody. 
B)  P1 antigen is poorly expressed at birth. 
C)  Anti-P1 does not react at 37°C. 
D)  Anti-P1 is a naturally occurring antibody. 
A)  Anti-P1 is an IgM antibody. 
B)  P1 antigen is poorly expressed at birth. 
C)  Anti-P1 does not react at 37°C. 
D)  Anti-P1 is a naturally occurring antibody.

Question 3

What is the most common genetic combination in the Kell blood group system?

Accepted Answer

A)  kKKpbJsb 
B)  kKpbJsaK11 
C)  kKpbJsbK11 
D)  KKpbJsbK11 
A)  kKKpbJsb 
B)  kKpbJsaK11 
C)  kKpbJsbK11 
D)  KKpbJsbK11

Question 4

What finding may protect individuals from making alloanti-Lub in dominant In(Lu) genotypes?

Accepted Answer

A)  The ability to neutralize anti-Lub 
B)  The ability to absorb and elute anti-Lub 
C)  Trace amounts of Lua on red blood cells 
D)  The ability to secrete Lub substance in plasma 
A)  The ability to neutralize anti-Lub 
B)  The ability to absorb and elute anti-Lub 
C)  Trace amounts of Lua on red blood cells 
D)  The ability to secrete Lub substance in plasma

Question 5

Most Kell autoantibodies are directed against which antigens that are usually undefined?

Accepted Answer

A)  Low-frequency 
B)  High-frequency 
C)  Soluble 
D)  Leukocyte 
A)  Low-frequency 
B)  High-frequency 
C)  Soluble 
D)  Leukocyte

Question 6

What is the function of a GPB-GPA hybrid (anti-Lepore type)?

Accepted Answer

A)  Encodes normal GPA 
B)  Encodes altered GPB 
C)  Encodes the COOH end of GPB 
D)  Encodes the NH2 end of GPB 
A)  Encodes normal GPA 
B)  Encodes altered GPB 
C)  Encodes the COOH end of GPB 
D)  Encodes the NH2 end of GPB

Question 7

Anti-Lea, which is reactive at the Coombs phase, may cause what kind of hemolysis?

Accepted Answer

A)  In vivo 
B)  In vitro 
C)  Intravascular 
D)  None of the above 
A)  In vivo 
B)  In vitro 
C)  Intravascular 
D)  None of the above

Question 8

Anti-I is found in association with what microorganism?

Accepted Answer

A)  Mycoplasma pneumoniae 
B)  Treponema pallidum 
C)  Escherichia coli 
D)  Proteus vulgaris 
A)  Mycoplasma pneumoniae 
B)  Treponema pallidum 
C)  Escherichia coli 
D)  Proteus vulgaris

Question 9

What Kidd antibody will react with all panel cells and phenotype as Jk(a-b-)?

Accepted Answer

A)  Anti-Jka 
B)  Anti-Jkb 
C)  Anti-Jk3 
D)  None of the above 
A)  Anti-Jka 
B)  Anti-Jkb 
C)  Anti-Jk3 
D)  None of the above

Question 10

A panel suggests that the patient has an anti-K antibody. All other clinically significant antibodies have been ruled out with the exception of Anti-E. Which of the following cells would be best to rule out the presence of the Anti-E?

Accepted Answer

A)  K+, k+, E-, e- 
B)  K- k+, E+, e+ 
C)  K-, k+, E+, e- 
D)  K+,k-,E-,e+ 
A)  K+, k+, E-, e- 
B)  K- k+, E+, e+ 
C)  K-, k+, E+, e- 
D)  K+,k-,E-,e+

Question 11

Which of the following may be a possible cause for the lack of expression of Lewis antigens during pregnancy?

Accepted Answer

A)  Increased ratio of plasma lipoproteins to RBC mass 
B)  Decreased ratio of plasma lipoproteins to RBC mass 
C)  Antigenic sites blocked by IgG antibody 
D)  Antigenic sites blocked by IgM antibody 
A)  Increased ratio of plasma lipoproteins to RBC mass 
B)  Decreased ratio of plasma lipoproteins to RBC mass 
C)  Antigenic sites blocked by IgG antibody 
D)  Antigenic sites blocked by IgM antibody

Question 12

Lewis antibodies are of what immunoglobulin class?

Accepted Answer

A)  IgM 
B)  IgG 
C)  IgA 
D)  IgE 
A)  IgM 
B)  IgG 
C)  IgA 
D)  IgE

Question 13

Why is dosage inconsistent in the Duffy blood group?

Accepted Answer

A)  The genotype could be inherited as FyaFyb or FyaFy for Fy(a+b-) red blood cells. 
B)  Antigen expression is depressed in low ionic strength media. 
C)  The genotype could be inherited as FyaFya or FyaFy for Fy(a+b-) red blood cells. 
D)  All of the above 
A)  The genotype could be inherited as FyaFyb or FyaFy for Fy(a+b-) red blood cells. 
B)  Antigen expression is depressed in low ionic strength media. 
C)  The genotype could be inherited as FyaFya or FyaFy for Fy(a+b-) red blood cells. 
D)  All of the above

Question 14

What MN phenotype is found in highest frequency in the white population?

Accepted Answer

A)  M+N+ 
B)  M+N- 
C)  M-N- 
D)  M-N+ 
A)  M+N+ 
B)  M+N- 
C)  M-N- 
D)  M-N+

Question 15

What is Kell's antithetical partner?

Accepted Answer

A)  Penney 
B)  Cellano 
C)  Sutter 
D)  Rautenberg 
A)  Penney 
B)  Cellano 
C)  Sutter 
D)  Rautenberg

Question 16

Of the following Rh gene complexes, which one gives rise to a red blood cell antigen that gives a positive reaction with anti-f sera?

Accepted Answer

A)  R1 
B)  R2 
C)  Ro 
D)  r' 
A)  R1 
B)  R2 
C)  Ro 
D)  r'

Question 17

What does the U in U antigen stand for?

Accepted Answer

A)  unusual 
B)  universal 
C)  uniform 
D)  unique 
A)  unusual 
B)  universal 
C)  uniform 
D)  unique

Question 18

Infection with which organism is associated with naturally occurring IgM anti-K.

Accepted Answer

A)  Escherichia coli 
B)  Mycobacterium species 
C)  Campylobacter coli 
D)  All of the above 
A)  Escherichia coli 
B)  Mycobacterium species 
C)  Campylobacter coli 
D)  All of the above

Question 19

Which of the following is known to enhance K antigen expression in the antihuman globulin test?

Accepted Answer

A)  LISS 
B)  DTT 
C)  Albumin 
D)  Polyethylene glycol 
A)  LISS 
B)  DTT 
C)  Albumin 
D)  Polyethylene glycol

Question 20

Anti-Lua reacts at what temperature?

Accepted Answer

A)  Room temperature 
B)  37°C 
C)  AHG 
D)  All of the above 
A)  Room temperature 
B)  37°C 
C)  AHG 
D)  All of the above

Exam 8: Blood Group Terminology and the Other Blood Groups

Which group of antigens below best represents the definition of high-frequency antigens?

Why is HDN not a consideration when the mother possesses anti-P1 in her serum?

What is the most common genetic combination in the Kell blood group system?

What finding may protect individuals from making alloanti-Lub in dominant In(Lu) genotypes?

Most Kell autoantibodies are directed against which antigens that are usually undefined?

What is the function of a GPB-GPA hybrid (anti-Lepore type)?

Anti-Lea, which is reactive at the Coombs phase, may cause what kind of hemolysis?

Anti-I is found in association with what microorganism?

What Kidd antibody will react with all panel cells and phenotype as Jk(a-b-)?

A panel suggests that the patient has an anti-K antibody. All other clinically significant antibodies have been ruled out with the exception of Anti-E. Which of the following cells would be best to rule out the presence of the Anti-E?

Which of the following may be a possible cause for the lack of expression of Lewis antigens during pregnancy?

Lewis antibodies are of what immunoglobulin class?

Why is dosage inconsistent in the Duffy blood group?

What MN phenotype is found in highest frequency in the white population?

What is Kell's antithetical partner?

Of the following Rh gene complexes, which one gives rise to a red blood cell antigen that gives a positive reaction with anti-f sera?

What does the U in U antigen stand for?

Infection with which organism is associated with naturally occurring IgM anti-K.

Which of the following is known to enhance K antigen expression in the antihuman globulin test?

Anti-Lua reacts at what temperature?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

Why is HDN not a consideration when the mother possesses anti-P₁ in her serum?

What finding may protect individuals from making alloanti-Lu^b in dominant In(Lu) genotypes?

Anti-Le^a, which is reactive at the Coombs phase, may cause what kind of hemolysis?

Anti-Lu^a reacts at what temperature?