Question 1

The Lu gene shares chromosome 19 with what other blood group gene?

Accepted Answer

A)  H 
B)  Le 
C)  LW 
D)  All of the above 
A)  H 
B)  Le 
C)  LW 
D)  All of the above

Question 2

What serologic factor distinguishes anti-Fy3 from anti-Fya or anti-Fyb?

Accepted Answer

A)  It is not destroyed by enzymes. 
B)  It is an IgM antibody. 
C)  It does not bind complement. 
D)  It does show dosage. 
A)  It is not destroyed by enzymes. 
B)  It is an IgM antibody. 
C)  It does not bind complement. 
D)  It does show dosage.

Question 3

What characteristic differentiates Ss antigens from MN antigens?

Accepted Answer

A)  Antigens well developed at birth 
B)  S and s exhibit dosage 
C)  Enzyme degradation 
D)  Biochemical structure rich in sialic acid 
A)  Antigens well developed at birth 
B)  S and s exhibit dosage 
C)  Enzyme degradation 
D)  Biochemical structure rich in sialic acid

Question 4

A cold antibody panel was performed to help identify an antibody that reacted at room temperature. The results of the panel are as follows: A1 cells = 0, A2 cells = 2+, B cells = 3+, O adult cells = 4+, Cord O cells = 1+. This is consistent with which antibody?

Accepted Answer

A)  Anti-IH 
B)  Anti-I 
C)  Anti-i 
D)  Aanti-H 
A)  Anti-IH 
B)  Anti-I 
C)  Anti-i 
D)  Aanti-H

Question 5

What is the biochemical structure of the P system antigens?

Accepted Answer

A)  Phospholipid 
B)  Glycophorin B 
C)  Glycosphingolipids 
D)  Glycophorin A 
A)  Phospholipid 
B)  Glycophorin B 
C)  Glycosphingolipids 
D)  Glycophorin A

Question 6

Which antigen(s) is/are antithetical partner(s) to s?

Accepted Answer

A)  MN 
B)  E 
C)  U 
D)  f 
A)  MN 
B)  E 
C)  U 
D)  f

Question 7

ISBT nomenclature for the Xg System is

Accepted Answer

A)  002 
B)  006 
C)  012 
D)  024 
A)  002 
B)  006 
C)  012 
D)  024

Question 8

How does anti-Lea differ from anti-Leb?

Accepted Answer

A)  Only anti-Lea will be produced in Le(a-b-) individuals. 
B)  Anti-Lea can bind complement more efficiently. 
C)  Anti-Leb is an IgG antibody. 
D)  Anti-Lea is an IgM antibody. 
A)  Only anti-Lea will be produced in Le(a-b-) individuals. 
B)  Anti-Lea can bind complement more efficiently. 
C)  Anti-Leb is an IgG antibody. 
D)  Anti-Lea is an IgM antibody.

Question 9

On which malaria receptor site is Duffy antigen dependent?

Accepted Answer

A)  Attachment receptor 
B)  Junction receptor 
C)  Ligand receptor 
D)  None of the above 
A)  Attachment receptor 
B)  Junction receptor 
C)  Ligand receptor 
D)  None of the above

Question 10

Bg antibodies are primarily directed toward antigenic determinants present on:

Accepted Answer

A)  white blood cells. 
B)  red blood cells. 
C)  platelets. 
D)  meso cells. 
A)  white blood cells. 
B)  red blood cells. 
C)  platelets. 
D)  meso cells.

Question 11

Why is it relatively easy to find compatible units for a patient with anti-K?

Accepted Answer

A)  Kell is a low-frequency antigen. 
B)  Kell is a high-frequency antigen. 
C)  Anti-K does not react at 37°C. 
D)  Anti-K has a low avidity for its respective antigen. 
A)  Kell is a low-frequency antigen. 
B)  Kell is a high-frequency antigen. 
C)  Anti-K does not react at 37°C. 
D)  Anti-K has a low avidity for its respective antigen.

Question 12

What is the definition of a blood group system?

Accepted Answer

A)  A group of antibodies produced by alleles at a single gene locus 
B)  A group of antigens produced by alleles at a single gene locus 
C)  A group of antibodies produced by alleles at multiple genetic loci 
D)  A group of antigens produced by alleles at multiple genetic loci 
A)  A group of antibodies produced by alleles at a single gene locus 
B)  A group of antigens produced by alleles at a single gene locus 
C)  A group of antibodies produced by alleles at multiple genetic loci 
D)  A group of antigens produced by alleles at multiple genetic loci

Question 13

What is a consequence of freezing Duffy-positive red blood cells in a low-ionic-strength media?

Accepted Answer

A)  Antigens will elute from red blood cells. 
B)  Reactivity of Duffy antibodies will be depressed. 
C)  Inhibitory substances will leak into plasma. 
D)  All of the above 
A)  Antigens will elute from red blood cells. 
B)  Reactivity of Duffy antibodies will be depressed. 
C)  Inhibitory substances will leak into plasma. 
D)  All of the above

Question 14

How are lipids dissociated from the red blood cell membrane for biochemical studies?

Accepted Answer

A)  Increased pH 
B)  Ion exchange 
C)  Sodium dodecyl sulfate 
D)  Organic solvents 
A)  Increased pH 
B)  Ion exchange 
C)  Sodium dodecyl sulfate 
D)  Organic solvents

Question 15

All of the following are characteristics of anti-M except:

Accepted Answer

A)  they are naturally occurring antibodies. 
B)  they do not bind complement. 
C)  they react stronger with enzyme-treated cells. 
D)  antibodies may exhibit an IgG component. 
A)  they are naturally occurring antibodies. 
B)  they do not bind complement. 
C)  they react stronger with enzyme-treated cells. 
D)  antibodies may exhibit an IgG component.

Question 16

Enzymes destroy the antigens of which of the following blood groups?

Accepted Answer

A)  N 
B)  Fya 
C)  M 
D)  All of the above 
A)  N 
B)  Fya 
C)  M 
D)  All of the above

Question 17

The genes that code for GPA and GPB are closely linked on the long arm of which chromosome?

Accepted Answer

A)  9 
B)  11 
C)  4 
D)  15 
A)  9 
B)  11 
C)  4 
D)  15

Question 18

The true Lewis phenotype will normally be detected at what age?

Accepted Answer

A)  Birth 
B)  10 days 
C)  6 years 
D)  Not necessarily ever, as circumstances such as pregnancy may alter or mask an individual's true Lewis phenotype 
A)  Birth 
B)  10 days 
C)  6 years 
D)  Not necessarily ever, as circumstances such as pregnancy may alter or mask an individual's true Lewis phenotype

Question 19

Persons who are negative for Duffy antigens are less likely to contract which of the following diseases?

Accepted Answer

A)  Chicken pox 
B)  Influenza 
C)  Malaria 
D)  Polio 
A)  Chicken pox 
B)  Influenza 
C)  Malaria 
D)  Polio

Question 20

Which antibody is viewed to be clinically significant because of its association with HTR and HDN?

Accepted Answer

A)  Anti-Bga 
B)  Anti-Kna 
C)  Anti-Dib 
D)  Anti-Cha 
A)  Anti-Bga 
B)  Anti-Kna 
C)  Anti-Dib 
D)  Anti-Cha

Exam 8: Blood Group Terminology and the Other Blood Groups

The Lu gene shares chromosome 19 with what other blood group gene?

What serologic factor distinguishes anti-Fy3 from anti-Fya or anti-Fyb?

What characteristic differentiates Ss antigens from MN antigens?

A cold antibody panel was performed to help identify an antibody that reacted at room temperature. The results of the panel are as follows: A1 cells = 0, A2 cells = 2+, B cells = 3+, O adult cells = 4+, Cord O cells = 1+. This is consistent with which antibody?

What is the biochemical structure of the P system antigens?

Which antigen(s) is/are antithetical partner(s) to s?

ISBT nomenclature for the Xg System is

How does anti-Lea differ from anti-Leb?

On which malaria receptor site is Duffy antigen dependent?

Bg antibodies are primarily directed toward antigenic determinants present on:

Why is it relatively easy to find compatible units for a patient with anti-K?

What is the definition of a blood group system?

What is a consequence of freezing Duffy-positive red blood cells in a low-ionic-strength media?

How are lipids dissociated from the red blood cell membrane for biochemical studies?

All of the following are characteristics of anti-M except:

Enzymes destroy the antigens of which of the following blood groups?

The genes that code for GPA and GPB are closely linked on the long arm of which chromosome?

The true Lewis phenotype will normally be detected at what age?

Persons who are negative for Duffy antigens are less likely to contract which of the following diseases?

Which antibody is viewed to be clinically significant because of its association with HTR and HDN?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

What serologic factor distinguishes anti-Fy3 from anti-Fy^a or anti-Fy^b?

A cold antibody panel was performed to help identify an antibody that reacted at room temperature. The results of the panel are as follows: A₁ cells = 0, A₂ cells = 2+, B cells = 3+, O adult cells = 4+, Cord O cells = 1+. This is consistent with which antibody?

How does anti-Le^a differ from anti-Le^b?