Question 1

How is the Luke (LKE) system related to the P blood group system?

Accepted Answer

A)  Anti-LKE reacts with all p individuals. 
B)  Anti-LKE reacts with all P1 and P2 individuals. 
C)  Persons who do not express the Luke antigen lack neuraminic acid. 
D)  Luke-positive individuals occur more in persons who are group O. 
A)  Anti-LKE reacts with all p individuals. 
B)  Anti-LKE reacts with all P1 and P2 individuals. 
C)  Persons who do not express the Luke antigen lack neuraminic acid. 
D)  Luke-positive individuals occur more in persons who are group O.

Question 2

Approximately what percentage of the black population is [Le(a-b-)]?

Accepted Answer

A)  78% 
B)  22% 
C)  15% 
D)  35% 
A)  78% 
B)  22% 
C)  15% 
D)  35%

Question 3

What portion of GPA reacts with anti- EnaFR?

Accepted Answer

A)  Phenylalanine resistant 
B)  Phenylalanine sensitive 
C)  Ficin resistant 
D)  Ficin sensitive 
A)  Phenylalanine resistant 
B)  Phenylalanine sensitive 
C)  Ficin resistant 
D)  Ficin sensitive

Question 4

Anti-Lu3 will be compatible with donor blood from individuals with which of the following phenotypes?

Accepted Answer

A)  Lu(a-b+) 
B)  Lu (a+b-) 
C)  Lu (a-b-) 
D)  Lu (a+b+) 
A)  Lu(a-b+) 
B)  Lu (a+b-) 
C)  Lu (a-b-) 
D)  Lu (a+b+)

Question 5

What Kell phenotype is found in highest frequency in the white population?

Accepted Answer

A)  K+k+ 
B)  K+k- 
C)  K-k+ 
D)  K0 
A)  K+k+ 
B)  K+k- 
C)  K-k+ 
D)  K0

Question 6

Why are Lewis antibodies not generally implicated in hemolytic disease of the newborn?

Accepted Answer

A)  Lewis antigens are well developed at birth. 
B)  Lewis antibodies are IgM and cannot cross the placenta. 
C)  Lewis antigens can readily dissociate from the red blood cell upon transfusion of Lewis-positive cells. 
D)  Lewis antibodies do not bind complement. 
A)  Lewis antigens are well developed at birth. 
B)  Lewis antibodies are IgM and cannot cross the placenta. 
C)  Lewis antigens can readily dissociate from the red blood cell upon transfusion of Lewis-positive cells. 
D)  Lewis antibodies do not bind complement.

Question 7

Why is anti-LebL the antibody of choice when phenotyping red blood cells?

Accepted Answer

A)  It reacts best with O and A2 cells. 
B)  It is dependent on the ABH antigens. 
C)  It is neutralized by H substance. 
D)  It recognizes any Leb antigen independent of ABO type. 
A)  It reacts best with O and A2 cells. 
B)  It is dependent on the ABH antigens. 
C)  It is neutralized by H substance. 
D)  It recognizes any Leb antigen independent of ABO type.

Question 8

Anti-Fs is more likely to react with which cells?

Accepted Answer

A)  Fy(a+b-) 
B)  Fy(a-b-) 
C)  Fy(a+b+) 
D)  Fy(a-b+) 
A)  Fy(a+b-) 
B)  Fy(a-b-) 
C)  Fy(a+b+) 
D)  Fy(a-b+)

Question 9

Black persons who genotype as Fy4Fy4 will phenotype as:

Accepted Answer

A)  Fy(a+b+) 
B)  Fy(a+b-) 
C)  Fy(a-b-) 
D)  Fy(a-b+) 
A)  Fy(a+b+) 
B)  Fy(a+b-) 
C)  Fy(a-b-) 
D)  Fy(a-b+)

Question 10

Where might you expect anti-Ytb to react in antibody screening?

Accepted Answer

A)  Immediate spin phase 
B)  37°C phase 
C)  IAT phase 
D)  All of the above 
A)  Immediate spin phase 
B)  37°C phase 
C)  IAT phase 
D)  All of the above

Question 11

All of the following are inconsistent with Xga antibody characteristics except:

Accepted Answer

A)  reactive at the IAT phase. 
B)  IgM immunoglobulins. 
C)  resistant to enzymes. 
D)  known to cause HTRs. 
A)  reactive at the IAT phase. 
B)  IgM immunoglobulins. 
C)  resistant to enzymes. 
D)  known to cause HTRs.

Question 12

Anti-Lua is destroyed by what enzyme?

Accepted Answer

A)  Trypsin 
B)  Ficin 
C)  Papain 
D)  All of the above 
A)  Trypsin 
B)  Ficin 
C)  Papain 
D)  All of the above

Question 13

What is the ISBT designation for the Kell system?

Accepted Answer

A)  001 
B)  009 
C)  006 
D)  100 
A)  001 
B)  009 
C)  006 
D)  100

Question 14

Which antigen in the high-incidence series (901) is usually IgM and occasionally causes hemolysis?

Accepted Answer

A)  Vel 
B)  JMH 
C)  Lan 
D)  Sda 
A)  Vel 
B)  JMH 
C)  Lan 
D)  Sda

Question 15

In order for an individual to express Leb antigen on their red blood cells, they must have inherited which gene?

Accepted Answer

A)  Le 
B)  Se 
C)  H 
D)  All of the above 
A)  Le 
B)  Se 
C)  H 
D)  All of the above

Question 16

What is the most common Lutheran phenotype in the white population?

Accepted Answer

A)  Lu(a+b-) 
B)  Lu(a-b-) 
C)  Lu(a-b+) 
D)  Lu(a+b+) 
A)  Lu(a+b-) 
B)  Lu(a-b-) 
C)  Lu(a-b+) 
D)  Lu(a+b+)

Question 17

Anti-Anton recognizes the same specificity as:

Accepted Answer

A)  anti-Wj. 
B)  anti-Aua. 
C)  anti-Lu3. 
D)  anti-Lub. 
A)  anti-Wj. 
B)  anti-Aua. 
C)  anti-Lu3. 
D)  anti-Lub.

Question 18

A blood bank technologist needed to confirm the presence of anti-P1 in a patient specimen. Fresh cells were not available for use, so an old panel that contained cells positive for P1 was used. No cells positive for the antigen reacted at any phase of the antiglobulin test, whereas cells from the screening cells showed specificity for the presence of anti-P1. What is a possible explanation for this?

Accepted Answer

A)  Technician omitted LISS 
B)  Patient expresses the p phenotype 
C)  P1 antigen deteriorates rapidly upon storage 
D)  Technician forgot to add AHG 
A)  Technician omitted LISS 
B)  Patient expresses the p phenotype 
C)  P1 antigen deteriorates rapidly upon storage 
D)  Technician forgot to add AHG

Question 19

How is Leb substance formed?

Accepted Answer

A)  L-fucose is added to subterminal N-acetylglucosamine of type 1 H substance. 
B)  L-fucose is added to subterminal N-acetylglucosamine of type 2 H substance. 
C)  Lea and Leb are codominant alleles located on chromosome 19. 
D)  Leb is secreted into plasma in the absence of fucosyltransferase. 
A)  L-fucose is added to subterminal N-acetylglucosamine of type 1 H substance. 
B)  L-fucose is added to subterminal N-acetylglucosamine of type 2 H substance. 
C)  Lea and Leb are codominant alleles located on chromosome 19. 
D)  Leb is secreted into plasma in the absence of fucosyltransferase.

Question 20

Lewis cell-bound antigens absorbed from plasma onto the red blood cell membranes are:

Accepted Answer

A)  glycoproteins. 
B)  glycolipids. 
C)  sphingolipids. 
D)  ceramides. 
A)  glycoproteins. 
B)  glycolipids. 
C)  sphingolipids. 
D)  ceramides.

Exam 8: Blood Group Terminology and the Other Blood Groups

How is the Luke (LKE) system related to the P blood group system?

Approximately what percentage of the black population is [Le(a-b-)]?

What portion of GPA reacts with anti- EnaFR?

Anti-Lu3 will be compatible with donor blood from individuals with which of the following phenotypes?

What Kell phenotype is found in highest frequency in the white population?

Why are Lewis antibodies not generally implicated in hemolytic disease of the newborn?

Why is anti-LebL the antibody of choice when phenotyping red blood cells?

Anti-Fs is more likely to react with which cells?

Black persons who genotype as Fy4Fy4 will phenotype as:

Where might you expect anti-Ytb to react in antibody screening?

All of the following are inconsistent with Xga antibody characteristics except:

Anti-Lua is destroyed by what enzyme?

What is the ISBT designation for the Kell system?

Which antigen in the high-incidence series (901) is usually IgM and occasionally causes hemolysis?

In order for an individual to express Leb antigen on their red blood cells, they must have inherited which gene?

What is the most common Lutheran phenotype in the white population?

Anti-Anton recognizes the same specificity as:

How is Leb substance formed?

Lewis cell-bound antigens absorbed from plasma onto the red blood cell membranes are:

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

What portion of GPA reacts with anti- En^aFR?

Why is anti-Le^bL the antibody of choice when phenotyping red blood cells?

Black persons who genotype as Fy⁴Fy⁴ will phenotype as:

Where might you expect anti-Yt^b to react in antibody screening?

All of the following are inconsistent with Xg^a antibody characteristics except:

Anti-Lu^a is destroyed by what enzyme?

In order for an individual to express Le^b antigen on their red blood cells, they must have inherited which gene?

How is Le^b substance formed?