Exam 5: Catecholamines

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Describe the release and actions of norepinephrine (NE) and epinephrine (EPI) associated with one-trial passive avoidance learning, which is used to study emotional memory consolidation.

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Why might a physician prescribe metoprolol rather than propranolol to treat high blood pressure?

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Which of the following most accurately represents the synthesis of the catecholamines?

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In the passive avoidance learning paradigm, learning is demonstrated by

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Explain how the two forms of the human COMT gene code for slightly different proteins and affect the prefrontal cortex differently.

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Noradrenergic receptors

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Draw a curve describing the relationship between noradrenergic activity in the prefrontal cortex and working memory. Explain what the curve shows and describe the presumed receptor mechanisms responsible.

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A patient with Parkinson's disease is being treated with a drug that has been shown to show improvements cognitive functioning. The patient's doctor notices that the drug is working and thus increases the dose only to find that the increased dose has a negative effect cognitive functions. Which drug is the doctor likely administering?

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Describe the relationship between noradrenergic α2-autoreceptors and opiate withdrawal, including pharmacological evidence supporting this relationship.

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The A9 and A10 cell groups are associated with the _______ and the _______, respectively.

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Under conditions of high excitatory input, a dopaminergic neuron can switch from _______ to _______, causing an increase in extracellular neurotransmitter levels.

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In the CNS, dopaminergic cell bodies are found primarily in the _______, whereas adrenergic cell bodies are found in the _______.

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To create a dopamine-deficient (DD) mouse that retains the ability to produce NE, the gene for _______ is selectively restored in noradrenergic neurons.

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The first means of inactivation of the catecholamines is

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Dopaminergic cell bodies in the VTA send projections to the nucleus accumbens and the amygdala via the _______ dopamine pathway.

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Which statement regarding receptor up-regulation is false?

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Write a coherent and informative paragraph incorporating the following terms: behavioral supersensitivity, 6-OHDA, antagonist, receptor up-regulation, D2 receptors.

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Increased levels of DA or NE in the nerve terminal decreases the rate of catecholamine synthesis by affecting the action of

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The dopamine pathway most important for regulating voluntary movement is the _______ pathway.

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The drugs Ritalin and Adderall are used to treat attention-deficit/hyperactivity disorder (ADHD) and work by _______ reuptake.

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