Exam 6: Serotonin

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Similar brain areas have been shown to be involved in fear/anxiety and aggression. Thus, before reacting to a threat a person evaluates present context and past experience, which dictates whether the person's response to the threat is _______ or _______.

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One of the current treatments for irritable bowel syndrome IBS-D is alosetron, which acts as a

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The deactivation and metabolism of serotonin

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Administration of _______ leads to a decrease in food intake, weight loss and other benefits for people that are overweight, such as lowering diabetes risk.

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Serotonin release in the gut is stimulated by

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One potential consequence of acute tryptophan depletion, (ATD) therapy is that

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The fibers of serotonergic neurons are found

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Identify the two ways by which 5-HT1A receptors exert their postsynaptic effects. List two kinds of evidence supporting a role for 5-HT1A receptors in regulating anxiety.

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Name the major serotonin cell clusters in the brainstem and describe their projection pathways.

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Explain how techniques of genetic engineering have contributed to our understanding of the behavioral and physiological functions of the serotonergic system.

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Like α1-adrenergic receptors, _______ receptors activate the phosphoinositide second-messenger system and thus increase intracellular _______ levels.

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_______ syndrome is caused by neuroendocrine tumors that release an overabundance of _______ into the bloodstream.

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What are the three major approaches to the study of the relationship between 5-HT and aggression in humans? What have these approaches showed us about the link between 5-HT and aggression?

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A specific marker for serotonin cells is

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Information regarding the effects of endogenous 5-HT on 5-HT1A receptors can be determined by administration of an antagonist such as

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Drugs that act as agonists at 5-HT2A receptors produce a characteristic "head-twitch" response in rodents, and _______ in humans.

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Pharmacologists have identified at least _______ different receptor subtypes for serotonin, most of which are _______.

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Why are cats the subject of choice in studies of firing patterns of dorsal raphe nucleus neurons? Describe the changes in firing of serotonergic neurons in the DRN of cats during different behavioral states.

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Anti-migraine drugs known as triptans act as _______ and cause _______ of blood vessels.

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Most of the cell bodies that produce serotonin in the CNS are found in the

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