Exam 20: Neurodegenerative Diseases, by Jennifer R : Yates, Lander University

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The comorbidity of HD with psychiatric symptoms/disorders is problematic for treatment of HD symptoms. Decreasing excess movement is achieved therapeutically by _______ or _______, but these treatments can lead to _______ and _______.

(Multiple Choice)
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Familial cases of AD (known as autosomal dominant Alzheimer's disease) are caused by mutations of _______ genes, including _______, and make up _______ of cases.

(Multiple Choice)
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Which of the following is not a symptom of Huntington's disease?

(Multiple Choice)
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Alzheimer's disease is the most common form of dementia, affecting _______ of the 25 million patients worldwide.

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The two most basic risk factors for AD are

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Which statement about shortcomings of treatment for PD is true?

(Multiple Choice)
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Explain the procedures used to assess disease progression in MS and identify/describe the four courses the disease can take, including the incidence of each.

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Which statement about the diagnosis of Alzheimer's disease is true?

(Multiple Choice)
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Huntington's disease is unusual compared to other neurodegenerative disorders in that

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The tau protein is normally associated with microtubules and is important in cellular function. In tangles, it is abnormally

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Which statement about apolipoprotein E, which has the gene greatest influence on risk of AD development, is true?

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Explain why l-DOPA is the primary drug treatment for Parkinson's disease. What is its mechanism of action? Identify three other ways DA receptor activation could be increased and name one drug from each of these categories.

(Essay)
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A critical characteristic of a good animal model of AD is

(Multiple Choice)
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People with ALS may experience _______, which is exaggeration of emotional responses, including uncontrolled laughing or crying, or laughing in sad situations and crying when others are laughing.

(Multiple Choice)
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Pharmacological treatments for Parkinson's disease include all of the following except drugs that

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The major consequence of degeneration of substantia nigra cells is a decrease in _______ input into the striatum, which results in less _______ of the globus pallidus and greater tonic inhibition of the _______, reducing _______ input to the cortex.

(Multiple Choice)
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_______ is a peculiar symptom of HD and manifests as _______.

(Multiple Choice)
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