Question 1

Which disorder is described as an unregulated release of thrombin with subsequent fibrin formation and accelerated fibrinolysis?

Accepted Answer

A)  Disseminated intravascular coagulation (DI
C)  
B)  Immune thrombocytopenic purpura (ITP) 
C)  Heparin induced thrombocytopenia (HIT) 
D)  Essential thrombocythemia (ET) 
A)  Disseminated intravascular coagulation (DI
C)  
B)  Immune thrombocytopenic purpura (ITP) 
C)  Heparin induced thrombocytopenia (HIT) 
D)  Essential thrombocythemia (ET)

Question 2

Early detection of acute leukemia would include which of the following symptoms?

Accepted Answer

A)  Dizziness,dehydration,palpitations,hypotension 
B)  Dyspnea,paresthesia,malaise 
C)  Bradycardia,abdominal pain,fever 
D)  Bruising,fatigue,bone pain,anorexia 
A)  Dizziness,dehydration,palpitations,hypotension 
B)  Dyspnea,paresthesia,malaise 
C)  Bradycardia,abdominal pain,fever 
D)  Bruising,fatigue,bone pain,anorexia

Question 3

Which electrolyte imbalance accompanies multiple myeloma?

Accepted Answer

A)  Hyperkalemia 
B)  Hypercalcemia 
C)  Hyperphosphatemia 
D)  Hypernatremia 
A)  Hyperkalemia 
B)  Hypercalcemia 
C)  Hyperphosphatemia 
D)  Hypernatremia

Question 4

MATCHING
Match the causes or diagnostic tests with the hematologic disorders.
-Multiple myeloma

Accepted Answer

A) Epstein-Barr virus 
B) Bence Jones protein 
C) Diagnosed by the Reed-Sternberg cell 
D) Diagnosed by the Philadelphia chromosome 
A) Epstein-Barr virus 
B) Bence Jones protein 
C) Diagnosed by the Reed-Sternberg cell 
D) Diagnosed by the Philadelphia chromosome

Question 5

Match the descriptions with the platelet disorders.
-Immune thrombocytopenic purpura (ITP)

Accepted Answer

A) Thrombi composed of platelets with minimal fibrin and erythrocytes occlude arterioles and capillaries 
B) Causes ischemic signs and symptoms in the central nervous system 
C) Caused by an alteration of multipotent stem cells,resulting in an excess production of platelets 
D) Antibody-coated platelets removed from circulation by mononuclear phagocytes in the spleen 
A) Thrombi composed of platelets with minimal fibrin and erythrocytes occlude arterioles and capillaries 
B) Causes ischemic signs and symptoms in the central nervous system 
C) Caused by an alteration of multipotent stem cells,resulting in an excess production of platelets 
D) Antibody-coated platelets removed from circulation by mononuclear phagocytes in the spleen

Question 6

Frequently the initial sign of Hodgkin disease is a painless mass,lump,or swelling,most commonly on the neck.

Accepted Answer

A) True 
 B)False

Question 7

A shift-to-the-left describes the premature release of immature neutrophils when the demand for mature neutrophils exceeds the supply.

Accepted Answer

A) True 
 B)False

Question 8

What is the most reliable and specific test for diagnosing disseminated intravascular coagulation (DIC)?

Accepted Answer

A)  Prothrombin time (PT) 
B)  Activated partial thromboplastin time (aPTT) 
C)  Fibrin degradation products (FDP) 
D)  D-dimer 
A)  Prothrombin time (PT) 
B)  Activated partial thromboplastin time (aPTT) 
C)  Fibrin degradation products (FDP) 
D)  D-dimer

Question 9

Match the descriptions with the platelet disorders.
-Thrombotic thrombocytopenic purpura (TTP)

Accepted Answer

A) Thrombi composed of platelets with minimal fibrin and erythrocytes occlude arterioles and capillaries 
B) Causes ischemic signs and symptoms in the central nervous system 
C) Caused by an alteration of multipotent stem cells,resulting in an excess production of platelets 
D) Antibody-coated platelets removed from circulation by mononuclear phagocytes in the spleen 
A) Thrombi composed of platelets with minimal fibrin and erythrocytes occlude arterioles and capillaries 
B) Causes ischemic signs and symptoms in the central nervous system 
C) Caused by an alteration of multipotent stem cells,resulting in an excess production of platelets 
D) Antibody-coated platelets removed from circulation by mononuclear phagocytes in the spleen

Question 10

What change is seen in leukocytes during an allergic disorder (type 1)often caused by asthma,hay fever,and drug reactions?

Accepted Answer

A)  Neutrophilia 
B)  Basophilia 
C)  Eosinophilia 
D)  Monocytosis 
A)  Neutrophilia 
B)  Basophilia 
C)  Eosinophilia 
D)  Monocytosis

Question 11

Which of the following is a description consistent with chronic lymphocytic leukemia (CLL)?

Accepted Answer

A)  There are defects in the ras oncogene,p53 tumor suppressor gene,and INK4A,the gene encoding a cell-cycle regulatory protein. 
B)  The bone marrow and peripheral blood are characterized by leukocytosis and a predominance of blast cells.As the immature blasts increase,they replace normal myelocytic cells,megakaryocytes,and erythrocytes. 
C)  There is failure of B cells to mature into plasma cells that synthesize immunoglobulins. 
D)  The translocation of genetic material from genes 9 and 22 create an abnormal,fused gene identified as BCR-ABL. 
A)  There are defects in the ras oncogene,p53 tumor suppressor gene,and INK4A,the gene encoding a cell-cycle regulatory protein. 
B)  The bone marrow and peripheral blood are characterized by leukocytosis and a predominance of blast cells.As the immature blasts increase,they replace normal myelocytic cells,megakaryocytes,and erythrocytes. 
C)  There is failure of B cells to mature into plasma cells that synthesize immunoglobulins. 
D)  The translocation of genetic material from genes 9 and 22 create an abnormal,fused gene identified as BCR-ABL.

Question 12

Vitamin _____ is required for normal clotting factor synthesis by the _____.

Accepted Answer

A)  K;kidneys 
B)  D;kidneys 
C)  K;liver 
D)  D;liver 
A)  K;kidneys 
B)  D;kidneys 
C)  K;liver 
D)  D;liver

Question 13

Philadelphia chromosome is present in lymph nodes of an individual with Hodgkin disease.

Accepted Answer

A) True 
 B)False

Question 14

In infectious mononucleosis (IM),what does the Monospot test detect?

Accepted Answer

A)  Immunoglobulin E (Ig
E)  
B)  Immunoglobulin M (IgM) 
C)  Immunoglobulin G (IgG) 
D)  Immunoglobulin A (Ig
A)  
A)  Immunoglobulin E (Ig
E)  
B)  Immunoglobulin M (IgM) 
C)  Immunoglobulin G (IgG) 
D)  Immunoglobulin A (Ig
A)

Question 15

_____ is the virus associated with Burkitt lymphoma in African children.

Accepted Answer

A)  Cytomegalovirus 
B)  Adenovirus 
C)  Human papillomavirus 
D)  Epstein-Barr virus 
A)  Cytomegalovirus 
B)  Adenovirus 
C)  Human papillomavirus 
D)  Epstein-Barr virus

Question 16

What is the most common cause of vitamin K deficiency?

Accepted Answer

A)  Administration of warfarin (Coumadin) 
B)  Total parenteral nutrition (TPN)with antibiotic therapy 
C)  An immunoglobulin G (IgG)-mediated autoimmune disorder 
D)  Liver failure 
A)  Administration of warfarin (Coumadin) 
B)  Total parenteral nutrition (TPN)with antibiotic therapy 
C)  An immunoglobulin G (IgG)-mediated autoimmune disorder 
D)  Liver failure

Question 17

A patient with bleeding disorder has a red-purplish discoloration caused by diffuse hemorrhage into skin tissues.The nurse documents this discoloration as:

Accepted Answer

A)  Petechiae 
B)  Hematoma 
C)  Ecchymosis 
D)  Purpura 
A)  Petechiae 
B)  Hematoma 
C)  Ecchymosis 
D)  Purpura

Question 18

MATCHING
Match the causes or diagnostic tests with the hematologic disorders.
-Hodgkin disease

Accepted Answer

A) Epstein-Barr virus 
B) Bence Jones protein 
C) Diagnosed by the Reed-Sternberg cell 
D) Diagnosed by the Philadelphia chromosome 
A) Epstein-Barr virus 
B) Bence Jones protein 
C) Diagnosed by the Reed-Sternberg cell 
D) Diagnosed by the Philadelphia chromosome

Question 19

Arterial thrombi are composed of erythrocytes with larger amounts of fibrin and very few platelets,whereas venous thrombi are composed of mostly platelets held together by fibrin strands.

Accepted Answer

A) True 
 B)False

Question 20

Non-Hodgkin lymphoma may be associated with Epstein Barr virus or hepatitis C virus.

Accepted Answer

A) True 
 B)False

Exam 46: Alterations of Leukocyte, Lymphoid, and Hemostatic Function

Which disorder is described as an unregulated release of thrombin with subsequent fibrin formation and accelerated fibrinolysis?

Early detection of acute leukemia would include which of the following symptoms?

Which electrolyte imbalance accompanies multiple myeloma?

MATCHING Match the causes or diagnostic tests with the hematologic disorders. -Multiple myeloma

Match the descriptions with the platelet disorders. -Immune thrombocytopenic purpura (ITP)

Frequently the initial sign of Hodgkin disease is a painless mass,lump,or swelling,most commonly on the neck.

A shift-to-the-left describes the premature release of immature neutrophils when the demand for mature neutrophils exceeds the supply.

What is the most reliable and specific test for diagnosing disseminated intravascular coagulation (DIC)?

Match the descriptions with the platelet disorders. -Thrombotic thrombocytopenic purpura (TTP)

What change is seen in leukocytes during an allergic disorder (type 1)often caused by asthma,hay fever,and drug reactions?

Which of the following is a description consistent with chronic lymphocytic leukemia (CLL)?

Vitamin _____ is required for normal clotting factor synthesis by the _____.

Philadelphia chromosome is present in lymph nodes of an individual with Hodgkin disease.

In infectious mononucleosis (IM),what does the Monospot test detect?

_____ is the virus associated with Burkitt lymphoma in African children.

What is the most common cause of vitamin K deficiency?

A patient with bleeding disorder has a red-purplish discoloration caused by diffuse hemorrhage into skin tissues.The nurse documents this discoloration as:

MATCHING Match the causes or diagnostic tests with the hematologic disorders. -Hodgkin disease

Arterial thrombi are composed of erythrocytes with larger amounts of fibrin and very few platelets,whereas venous thrombi are composed of mostly platelets held together by fibrin strands.

Non-Hodgkin lymphoma may be associated with Epstein Barr virus or hepatitis C virus.

Cellular Biology

Altered Cellular and Tissue Biology

The Cellular Environment

Genes and Genetic Diseases

Genes, Environment-Lifestyle, and Common Diseases

Innate Immunity Including Inflammation

Adaptive Immunity

Alterations in Immunity and Inflammation Including Hypersensitivies

Infection Including Hivaids

Stress and Disease

Biology of Cancer

Tumor Invasion and Metastasis

Cancer in Children

Structure and Function of the Neurologic System

Pain, Temperature Regulation, Sleep, and Sensory Function

Concepts of Neurologic Dysfunction

Disorders of Neurologic Function

Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

Alterations of Neurologic Function in Children

Mechanisms of Hormonal Regulation

Alterations of Hormonal Regulation

Structure and Function of the Reproductive Systems

Alterations of the Reproductive Systems

Sexually Transmitted Infections

Structure and Function of the Hematologic System

Alterations of Erythrocyte Function

Alterations in Hematologic Function in Children

Structure and Function of the Cardiovascular and Lymphatic Systems

Alterations of Cardiovascular Function

Alterations of Cardiovascular Function in Children

Structure and Function of the Pulmonary System

Alterations of Pulmonary Function

Structure and Function of the Renal and Urologic Systems

Alterations of Renal and Urinary Tract Function

Alterations of Renal and Urinary Tract Function in Children

Structure and Function of the Digestive System

Alterations of Digestive Function

Alterations of Digestive Function in Children

Structure and Function of the Musculoskeletal System

Alterations of Musculoskeletal Function

Alterations of Musculoskeletal Function in Children

Structure, Function, and Disorders of the Integument

Alterations of the Integument in Children

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

Alterations of Pulmonary Function in Children

Filters

Vitamin _ is required for normal clotting factor synthesis by the _.