Exam 27: Antimicrobial Therapy

A newly isolated antibiotic that kills Klebsiella sp. was found in soil bacteria. Chemical analysis showed the structure of this molecule to contain a cysteine/valine ring structure. This new antibiotic would be classified as a ________ inhibitor.

A novel antibiotic, discovered to treat blood-borne bacteria during sepsis infection, is found to have a dramatic effect during MIC assays. Mice studies that followed found the drug to be cleared from the body within 15 minutes of oral administration. Would this be a good drug candidate for sepsis? Why or why not? What suggestions would you make? Support your answer.

Summarize how infection is cleared from the body of a patient who has been prescribed antibiotics that are bacteriostatic. Give one example of a bacteriostatic antibiotic in your answer.

Most antiviral drugs approved for clinical use target viral proteins. Which of the following is NOT a targeted viral protein?

The antiviral nucleoside inhibitor zidovudine, used in treating HIV infection, works by

Gene-expression elements that account for rapid transmission of drug resistance due to their mobility and ability to collect resistance gene cassettes are called

A possible effective treatment for a patient who comes into a medical office with tuberculosis has been derived from

Bactrim, a sulfa drug used to treat urinary tract infections, does NOT harm host cells because eukaryotic cells

How does saving the rain forest (and other endangered habitats) correlate with the fight to prevent human morbidity and mortality caused by bacterial disease? Give an example to support your argument.

A persister cell is an unsolved mystery of microbiology because these cells

Bactericidal antibiotics include all of the following EXCEPT

The best target for development of a new antibiotic would be