Exam 27: Antimicrobial Therapy

A standardized inoculum of bacteria is used in all microbiology labs when performing a Kirby-Bauer assay. This standard allows for a visual turbidity reading to achieve reproducibility in the number of bacteria inoculated on a plate. This is most important because

One way a macrolide-producing organism, such as Streptomyces sp., prevents its own demise from production of the antibiotic is to

Several antifungal therapeutic agents act to inhibit sterol synthesis. Explain why this does NOT affect mammalian systems.

A persister cell is an unsolved mystery of microbiology because these cells

Why is metronidazole uneffective against an aerobic bacteria like Staphylococcus aureas?

An example of an antibiotic that binds to the 30S ribosomal subunit would be

If a drug were designed that only seemed to affect the growth of Burkholderia pseudomallei, this drug would be considered ________ range.

A newly isolated antibiotic that kills Klebsiella sp. was found in soil bacteria. Chemical analysis showed the structure of this molecule to contain a cysteine/valine ring structure. This new antibiotic would be classified as a ________ inhibitor.

What microbe would you grow if you wanted to prepare and isolate some vancomycin?

A bacterial strain exhibiting a unique RNA polymerase structure would most likely inhibit the activity of which antibiotic?

A bacterium has evolved a new enzyme that can cleave a beta-lactam ring structure. It would NOT be treatable by which class of drugs?

A patient suffering from a systemic mycosis with aspergillosis would best be served by which antifungal?