Question 1

Immunoglobulin prepared from pooled plasma is primarily:

Accepted Answer

A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE 
A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE

Question 2

Oncology patients usually receive repeated red blood cell and platelet transfusions because of:

Accepted Answer

A)  radiation therapy. 
B)  tumor infiltration of bone marrow. 
C)  chemotherapy. 
D)  all of the above. 
A)  radiation therapy. 
B)  tumor infiltration of bone marrow. 
C)  chemotherapy. 
D)  all of the above.

Question 3

What is the only blood component that provides high concentrations of vWF?

Accepted Answer

A)  FFP 
B)  Whole blood 
C)  Platelets 
D)  Cryoprecipitated AHF 
A)  FFP 
B)  Whole blood 
C)  Platelets 
D)  Cryoprecipitated AHF

Question 4

Deglycerolized red blood cells can be used interchangeably with washed red blood cells, because both procedures:

Accepted Answer

A)  remove white blood cells. 
B)  remove plasma. 
C)  have 24-hour outdate. 
D)  all of the above 
A)  remove white blood cells. 
B)  remove plasma. 
C)  have 24-hour outdate. 
D)  all of the above

Question 5

A patient with hypofibrinogenemia is receiving cryoprecipitate on an outpatient basis. His plasma volume is 4,000 mL, and his physician wants to increase factor I from 40 mg/dL to 120 mg/dL. How many bags of cryoprecipitate are needed?

Accepted Answer

A)  8 
B)  13 
C)  15 
D)  21 
A)  8 
B)  13 
C)  15 
D)  21

Question 6

Platelets prepared from are referred to as random donor platelets.

Accepted Answer

A)  recovered plasma 
B)  pheresis products 
C)  whole blood units 
D)  red blood cells 
A)  recovered plasma 
B)  pheresis products 
C)  whole blood units 
D)  red blood cells

Question 7

Leukoreduction filters are used in the transfusion of red blood cells and platelets to prevent:

Accepted Answer

A)  nonfebrile hemolytic transfusion reactions. 
B)  febrile hemolytic transfusion reactions. 
C)  febrile nonhemolytic transfusion reactions. 
D)  nonfebrile nonhemolytic transfusion reactions. 
A)  nonfebrile hemolytic transfusion reactions. 
B)  febrile hemolytic transfusion reactions. 
C)  febrile nonhemolytic transfusion reactions. 
D)  nonfebrile nonhemolytic transfusion reactions.

Question 8

Neonatal exchange transfusion is performed using which blood preservative?

Accepted Answer

A)  AS-1 
B)  Citrate-phosphate-dextrose (CP
D)  
C)  Citrate-phosphate-dextrose adenine (CPDA-1) 
D)  Both B and C can be safely used 
A)  AS-1 
B)  Citrate-phosphate-dextrose (CP
D)  
C)  Citrate-phosphate-dextrose adenine (CPDA-1) 
D)  Both B and C can be safely used

Question 9

What is the purpose of dialysis in uremic patients?

Accepted Answer

A)  Release of functional von Willebrand factor (vWF) from endothelial cells 
B)  Removal of by-products of protein metabolism that renders vWF and platelets nonfunctional 
C)  Release of platelets from the bone marrow 
D)  All of the above 
A)  Release of functional von Willebrand factor (vWF) from endothelial cells 
B)  Removal of by-products of protein metabolism that renders vWF and platelets nonfunctional 
C)  Release of platelets from the bone marrow 
D)  All of the above

Question 10

All of the following are consistent with graft-versus-host disease (GVHD) except:

Accepted Answer

A)  transplantation of immunocompetent T lymphocytes. 
B)  HLA incompatibility between graft and recipient. 
C)  transplantation of "immunologically naive" T lymphocytes. 
D)  an immunocompromised recipient. 
A)  transplantation of immunocompetent T lymphocytes. 
B)  HLA incompatibility between graft and recipient. 
C)  transplantation of "immunologically naive" T lymphocytes. 
D)  an immunocompromised recipient.

Question 11

Antithrombin III concentrates are used in the treatment of:

Accepted Answer

A)  dysfibrinogenemia. 
B)  acquired antithrombin III deficiency caused by DIC. 
C)  hereditary antithrombin III deficiency caused by venous thrombosis. 
D)  all of the above 
A)  dysfibrinogenemia. 
B)  acquired antithrombin III deficiency caused by DIC. 
C)  hereditary antithrombin III deficiency caused by venous thrombosis. 
D)  all of the above

Question 12

Why is the increase in hemoglobin and hematocrit evident more quickly in red blood cell transfusions than in whole blood transfusions?

Accepted Answer

A)  Blood volume adjustment is less when red blood cells are transfused. 
B)  Blood volume adjustment is greater when red blood cells are transfused. 
C)  Whole blood takes longer to mix. 
D)  Whole blood is usually transfused through a porous filter. 
A)  Blood volume adjustment is less when red blood cells are transfused. 
B)  Blood volume adjustment is greater when red blood cells are transfused. 
C)  Whole blood takes longer to mix. 
D)  Whole blood is usually transfused through a porous filter.

Question 13

Which component(s) provide(s) a concentrated source of fibrinogen?

Accepted Answer

A)  Fresh or frozen RBCs and FFP 
B)  FFP and cryoprecipitate 
C)  Cryoprecipitate 
D)  Random donor platelets and plasma 
A)  Fresh or frozen RBCs and FFP 
B)  FFP and cryoprecipitate 
C)  Cryoprecipitate 
D)  Random donor platelets and plasma

Question 14

Which of the following is an indication for plasma transfusion in a patient who has been massively transfused?

Accepted Answer

A)  PT = 12 seconds 
B)  PTT greater than 60 seconds 
C)  Fibrinogen = 120 mg/dL 
D)  Platelets = 25,000/µL 
A)  PT = 12 seconds 
B)  PTT greater than 60 seconds 
C)  Fibrinogen = 120 mg/dL 
D)  Platelets = 25,000/µL

Question 15

Granulocytes for transfusion should:

Accepted Answer

A)  be administered through a microaggregate filter. 
B)  be ABO- and Rh-compatible with the recipient's serum. 
C)  be infused within 72 hours of collection. 
D)  never be transfused to patients with a history of febrile transfusion reaction. 
A)  be administered through a microaggregate filter. 
B)  be ABO- and Rh-compatible with the recipient's serum. 
C)  be infused within 72 hours of collection. 
D)  never be transfused to patients with a history of febrile transfusion reaction.

Question 16

How would the hematocrit of a patient with chronic anemia be affected by transfusion of 2 units of whole blood versus transfusion with 3 units of packed RBCs?

Accepted Answer

A)  Patient's hematocrit would be equally affected. 
B)  The packed RBCs would increase the hematocrit more than the whole blood. 
C)  The whole blood would increase the hematocrit more than the packed RBCs. 
D)  The hematocrit would not change at all with the whole blood because of the plasma in the unit. 
A)  Patient's hematocrit would be equally affected. 
B)  The packed RBCs would increase the hematocrit more than the whole blood. 
C)  The whole blood would increase the hematocrit more than the packed RBCs. 
D)  The hematocrit would not change at all with the whole blood because of the plasma in the unit.

Question 17

Which of the following methods provides the purest factor VIII concentrates?

Accepted Answer

A)  Anion exchange chromatography 
B)  Monoclonal antibody purification 
C)  DNA technology 
D)  Pasteurization 
A)  Anion exchange chromatography 
B)  Monoclonal antibody purification 
C)  DNA technology 
D)  Pasteurization

Question 18

Which platelet pheresis product should be irradiated?

Accepted Answer

A)  Autologous unit collected prior to surgery 
B)  Random stock unit going to a patient with disseminated intravascular coagulation (DI
C)  
C)  A directed donation given by a mother to her son 
D)  A directed donation given by an unrelated family friend 
A)  Autologous unit collected prior to surgery 
B)  Random stock unit going to a patient with disseminated intravascular coagulation (DI
C)  
C)  A directed donation given by a mother to her son 
D)  A directed donation given by an unrelated family friend

Question 19

What is used to anticoagulate the shed blood obtained from intraoperative salvage?

Accepted Answer

A)  EDTA 
B)  Citrate 
C)  Heparin 
D)  Citrate and heparin 
A)  EDTA 
B)  Citrate 
C)  Heparin 
D)  Citrate and heparin

Question 20

Why is thrombocytopenia a manifestation of a massive transfusion?

Accepted Answer

A)  Platelets are diluted by resuscitation fluids and stored blood. 
B)  Platelets are refractory to infused blood. 
C)  Platelets are sequestered in the spleen due to abnormal hemodynamics. 
D)  None of the above 
A)  Platelets are diluted by resuscitation fluids and stored blood. 
B)  Platelets are refractory to infused blood. 
C)  Platelets are sequestered in the spleen due to abnormal hemodynamics. 
D)  None of the above

Exam 16: Transfusion Therapy

Immunoglobulin prepared from pooled plasma is primarily:

Oncology patients usually receive repeated red blood cell and platelet transfusions because of:

What is the only blood component that provides high concentrations of vWF?

Deglycerolized red blood cells can be used interchangeably with washed red blood cells, because both procedures:

A patient with hypofibrinogenemia is receiving cryoprecipitate on an outpatient basis. His plasma volume is 4,000 mL, and his physician wants to increase factor I from 40 mg/dL to 120 mg/dL. How many bags of cryoprecipitate are needed?

Platelets prepared from are referred to as random donor platelets.

Leukoreduction filters are used in the transfusion of red blood cells and platelets to prevent:

Neonatal exchange transfusion is performed using which blood preservative?

What is the purpose of dialysis in uremic patients?

All of the following are consistent with graft-versus-host disease (GVHD) except:

Antithrombin III concentrates are used in the treatment of:

Why is the increase in hemoglobin and hematocrit evident more quickly in red blood cell transfusions than in whole blood transfusions?

Which component(s) provide(s) a concentrated source of fibrinogen?

Which of the following is an indication for plasma transfusion in a patient who has been massively transfused?

Granulocytes for transfusion should:

How would the hematocrit of a patient with chronic anemia be affected by transfusion of 2 units of whole blood versus transfusion with 3 units of packed RBCs?

Which of the following methods provides the purest factor VIII concentrates?

Which platelet pheresis product should be irradiated?

What is used to anticoagulate the shed blood obtained from intraoperative salvage?

Why is thrombocytopenia a manifestation of a massive transfusion?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters