Question 1

Cryoprecipitate AHF contains factor VIII. What other coagulation factor is present?

Accepted Answer

A)  I 
B)  V 
C)  VII 
D)  XII 
A)  I 
B)  V 
C)  VII 
D)  XII

Question 2

How is cryoprecipitated AHF used with prosthetic vascular grafts?

Accepted Answer

A)  Bovine thrombin activates factor XIII, which acts as a fibrin solvent to prime grafts. 
B)  Bovine thrombin activates factor VIII, which acts as a fibrin glue to seal gaps. 
C)  Bovine thrombin activates fibrinogen, which acts as a fibrin glue to seal gaps. 
D)  None of the above 
A)  Bovine thrombin activates factor XIII, which acts as a fibrin solvent to prime grafts. 
B)  Bovine thrombin activates factor VIII, which acts as a fibrin glue to seal gaps. 
C)  Bovine thrombin activates fibrinogen, which acts as a fibrin glue to seal gaps. 
D)  None of the above

Question 3

Cryoprecipitate is not used to treat which condition?

Accepted Answer

A)  Hemophilia A 
B)  von Willebrand's disease 
C)  Hemophilia B 
D)  Hypofibrinogenemia 
A)  Hemophilia A 
B)  von Willebrand's disease 
C)  Hemophilia B 
D)  Hypofibrinogenemia

Question 4

A 160-pound man was transfused with 1 unit of whole blood after being rescued from a burning apartment building. His hematocrit was determined to be 27% before transfusion. What would you expect his hematocrit to be in 48 hours?

Accepted Answer

A)  28% 
B)  30% 
C)  40% 
D)  45% 
A)  28% 
B)  30% 
C)  40% 
D)  45%

Question 5

Why is it recommended that factor VIII concentrates be used in patients with von Willebrand's disease?

Accepted Answer

A)  Because of the variability in vWF content 
B)  Because of factor VIII's short half-life 
C)  Factor VIII concentrates are reserved for hemophiliacs. 
D)  All of the above 
A)  Because of the variability in vWF content 
B)  Because of factor VIII's short half-life 
C)  Factor VIII concentrates are reserved for hemophiliacs. 
D)  All of the above

Question 6

What whole blood component contained in pheresed granulocyte concentrate warrants crossmatching of this product?

Accepted Answer

A)  White blood cells 
B)  Red blood cells 
C)  Platelets 
D)  Plasma 
A)  White blood cells 
B)  Red blood cells 
C)  Platelets 
D)  Plasma

Question 7

A patient with severe hemolytic anemia had a pulse of 120 beats per minute and a respiratory rate of 37 breaths per minute. What blood component is indicated for this patient?

Accepted Answer

A)  Plasma 
B)  Whole blood 
C)  Red blood cells 
D)  Platelets 
A)  Plasma 
B)  Whole blood 
C)  Red blood cells 
D)  Platelets

Question 8

What plasma product is used to replace fluid in patients undergoing plasmapheresis procedures?

Accepted Answer

A)  Albumin 
B)  Plasma protein fraction 
C)  Immune globulin 
D)  Cryoprecipitate 
A)  Albumin 
B)  Plasma protein fraction 
C)  Immune globulin 
D)  Cryoprecipitate

Question 9

What is the corrected platelet increment for a patient with a body surface area of 2.7 m2, an initial count of 15,000 per µL, and a 1-hour post-transfusion platelet count of 80,000 per µL given one apheresed platelet component?

Accepted Answer

A)  53,182 per µL 
B)  58,500 per µL 
C)  31,900 per µL 
D)  5,000 per µL 
A)  53,182 per µL 
B)  58,500 per µL 
C)  31,900 per µL 
D)  5,000 per µL

Question 10

Why is red blood cell transfusion contraindicated in a stable patient with chronic renal failure who has no symptoms except after climbing three flights of stairs?

Accepted Answer

A)  The anemia is compensated. 
B)  The anemia is a "nutritional anemia." 
C)  Whole blood is recommended because the plasma volume is decreased in these patients. 
D)  None of the above 
A)  The anemia is compensated. 
B)  The anemia is a "nutritional anemia." 
C)  Whole blood is recommended because the plasma volume is decreased in these patients. 
D)  None of the above

Question 11

Vitamin K is essential for the carboxylation of which coagulation factors?

Accepted Answer

A)  I, VII, IX, X 
B)  I, V, IX, X 
C)  II, VII, IX, X 
D)  II, VII, XI, XII 
A)  I, VII, IX, X 
B)  I, V, IX, X 
C)  II, VII, IX, X 
D)  II, VII, XI, XII

Question 12

The pathological cause of a decreased red blood cell mass include(s):

Accepted Answer

A)  compromised bone marrow production. 
B)  decreased red blood cell survival. 
C)  bleeding as a result of trauma. 
D)  all of the above 
A)  compromised bone marrow production. 
B)  decreased red blood cell survival. 
C)  bleeding as a result of trauma. 
D)  all of the above

Question 13

Which of the following is not an indication for transfusing platelets?

Accepted Answer

A)  Thrombocytopenia with bleeding or invasive procedure 
B)  Disseminated intravascular coagulation 
C)  Chemotherapy for malignancy 
D)  Massive transfusion, platelet count 250,000/µL 
A)  Thrombocytopenia with bleeding or invasive procedure 
B)  Disseminated intravascular coagulation 
C)  Chemotherapy for malignancy 
D)  Massive transfusion, platelet count 250,000/µL

Question 14

What disease state may require exogenous fibrinogen replacement?

Accepted Answer

A)  Disseminated intravascular coagulation 
B)  Liver failure 
C)  Congenital fibrinogen deficiency 
D)  All of the above 
A)  Disseminated intravascular coagulation 
B)  Liver failure 
C)  Congenital fibrinogen deficiency 
D)  All of the above

Question 15

Which intravenous solution is not recommended for dilution of blood components because of red blood cell damage?

Accepted Answer

A)  0.9% saline 
B)  Dextrose 
C)  5% albumin 
D)  Plasma 
A)  0.9% saline 
B)  Dextrose 
C)  5% albumin 
D)  Plasma

Question 16

Poor increment in the platelet count 1 hour following platelet transfusion is most commonly caused by:

Accepted Answer

A)  splenomegaly. 
B)  alloimmunization to HLA antigens. 
C)  disseminated intravascular coagulation. 
D)  defective platelets. 
A)  splenomegaly. 
B)  alloimmunization to HLA antigens. 
C)  disseminated intravascular coagulation. 
D)  defective platelets.

Question 17

What is the advantage of performing a type and screen for patients scheduled for surgery instead of crossmatching units for possible transfusion?

Accepted Answer

A)  Increases the amount of crossmatch performed 
B)  Increases the availability of donor units in the inventory 
C)  Contributes to outdating of blood products 
D)  Decreases the number of panel studies done on positive antibody screens 
A)  Increases the amount of crossmatch performed 
B)  Increases the availability of donor units in the inventory 
C)  Contributes to outdating of blood products 
D)  Decreases the number of panel studies done on positive antibody screens

Question 18

Which of the following is an indication for immunoglobulin administration?

Accepted Answer

A)  Cytomegalovirus 
B)  Hepatitis A 
C)  Infectious mononucleosis 
D)  Congenital hypergammaglobulinemia 
A)  Cytomegalovirus 
B)  Hepatitis A 
C)  Infectious mononucleosis 
D)  Congenital hypergammaglobulinemia

Question 19

How is the whole blood that is collected from a donor different from whole blood circulating in someone's blood vessels?

Accepted Answer

A)  The anticoagulant in donor blood prevents activation of the coagulation system. 
B)  The citrate mixed with donor blood serves as substrate for red blood cell metabolism. 
C)  The pH of whole blood is higher in collected units than in blood vessels. 
D)  Immunogenicity is diminished in collected units. 
A)  The anticoagulant in donor blood prevents activation of the coagulation system. 
B)  The citrate mixed with donor blood serves as substrate for red blood cell metabolism. 
C)  The pH of whole blood is higher in collected units than in blood vessels. 
D)  Immunogenicity is diminished in collected units.

Question 20

Which of the following is not an indication for fresh frozen plasma (FFP) transfusion?

Accepted Answer

A)  Disseminated intravascular coagulation (DI
C)  
B)  Vitamin K deficiency 
C)  Factor VIII deficiency 
D)  Massive transfusion 
A)  Disseminated intravascular coagulation (DI
C)  
B)  Vitamin K deficiency 
C)  Factor VIII deficiency 
D)  Massive transfusion

Exam 16: Transfusion Therapy

Cryoprecipitate AHF contains factor VIII. What other coagulation factor is present?

How is cryoprecipitated AHF used with prosthetic vascular grafts?

Cryoprecipitate is not used to treat which condition?

A 160-pound man was transfused with 1 unit of whole blood after being rescued from a burning apartment building. His hematocrit was determined to be 27% before transfusion. What would you expect his hematocrit to be in 48 hours?

Why is it recommended that factor VIII concentrates be used in patients with von Willebrand's disease?

What whole blood component contained in pheresed granulocyte concentrate warrants crossmatching of this product?

A patient with severe hemolytic anemia had a pulse of 120 beats per minute and a respiratory rate of 37 breaths per minute. What blood component is indicated for this patient?

What plasma product is used to replace fluid in patients undergoing plasmapheresis procedures?

What is the corrected platelet increment for a patient with a body surface area of 2.7 m2, an initial count of 15,000 per µL, and a 1-hour post-transfusion platelet count of 80,000 per µL given one apheresed platelet component?

Why is red blood cell transfusion contraindicated in a stable patient with chronic renal failure who has no symptoms except after climbing three flights of stairs?

Vitamin K is essential for the carboxylation of which coagulation factors?

The pathological cause of a decreased red blood cell mass include(s):

Which of the following is not an indication for transfusing platelets?

What disease state may require exogenous fibrinogen replacement?

Which intravenous solution is not recommended for dilution of blood components because of red blood cell damage?

Poor increment in the platelet count 1 hour following platelet transfusion is most commonly caused by:

What is the advantage of performing a type and screen for patients scheduled for surgery instead of crossmatching units for possible transfusion?

Which of the following is an indication for immunoglobulin administration?

How is the whole blood that is collected from a donor different from whole blood circulating in someone's blood vessels?

Which of the following is not an indication for fresh frozen plasma (FFP) transfusion?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters

What is the corrected platelet increment for a patient with a body surface area of 2.7 m², an initial count of 15,000 per µL, and a 1-hour post-transfusion platelet count of 80,000 per µL given one apheresed platelet component?