Question 1

Why is it essential that irradiated blood components be used in bone marrow transplant recipients?

Accepted Answer

A)  Irradiation counteracts the effects of neutrophil toxicity. 
B)  Bone marrow recipients demonstrate hyperimmunity to lymphocytes. 
C)  Bone marrow recipients are on immunosuppressive therapy. 
D)  None of the above 
A)  Irradiation counteracts the effects of neutrophil toxicity. 
B)  Bone marrow recipients demonstrate hyperimmunity to lymphocytes. 
C)  Bone marrow recipients are on immunosuppressive therapy. 
D)  None of the above

Question 2

What is the best-tolerated form of transplantation in humans?

Accepted Answer

A)  Red blood cells 
B)  Platelets 
C)  Bone marrow 
D)  Liver 
A)  Red blood cells 
B)  Platelets 
C)  Bone marrow 
D)  Liver

Question 3

Which of the following may be a serious manifestation of FFP transfusion in congenital factor deficiencies?

Accepted Answer

A)  Tachycardia 
B)  Pleurisy 
C)  Hypogammaglobulinemia 
D)  Pulmonary edema 
A)  Tachycardia 
B)  Pleurisy 
C)  Hypogammaglobulinemia 
D)  Pulmonary edema

Question 4

Which of the following criteria warrants a granulocyte concentrate transfusion?

Accepted Answer

A)  A neutrophil count greater than 1,000 per µL 
B)  A septic patient unresponsive to antibiotics 
C)  Bone marrow hyperplasia 
D)  None of the above 
A)  A neutrophil count greater than 1,000 per µL 
B)  A septic patient unresponsive to antibiotics 
C)  Bone marrow hyperplasia 
D)  None of the above

Question 5

What are the requirements for a transfusion to be classified as massive in an adult?

Accepted Answer

A)  5 units within 24 hours 
B)  10 units within 24 hours 
C)  5 units within 1 week 
D)  10 units within 1 week 
A)  5 units within 24 hours 
B)  10 units within 24 hours 
C)  5 units within 1 week 
D)  10 units within 1 week

Question 6

Cryoprecipitate AHF contains how much fibrinogen?

Accepted Answer

A)  500 to 750 mg 
B)  50 to 100 mg 
C)  150 to 250 mg 
D)  250 to 400 mg 
A)  500 to 750 mg 
B)  50 to 100 mg 
C)  150 to 250 mg 
D)  250 to 400 mg

Question 7

What hemoglobin level is considered critical and may warrant a red blood cell transfusion?

Accepted Answer

A)  10 g/dL 
B)  7 g/dL 
C)  12 g/dL 
D)  9 g/dL 
A)  10 g/dL 
B)  7 g/dL 
C)  12 g/dL 
D)  9 g/dL

Question 8

Factor IX concentrates contain which factors (otherwise known as "prothrombin complex")?

Accepted Answer

A)  I, V, VII, IX 
B)  II, V, VII, IX 
C)  II, VII, IX, X 
D)  V, VII, IX, XII 
A)  I, V, VII, IX 
B)  II, V, VII, IX 
C)  II, VII, IX, X 
D)  V, VII, IX, XII

Question 9

Liquid plasma is not indicated for factor deficiency.

Accepted Answer

A)  XI 
B)  V 
C)  II 
D)  X 
A)  XI 
B)  V 
C)  II 
D)  X

Question 10

Cryoprecipitated AHF can be used to treat von Willebrand's disease by providing vWF after has failed to release adequate amounts of endogenous vWF.

Accepted Answer

A)  exogenous/DDAVP 
B)  endogenous/DDAVP 
C)  exogenous/factor VIII concentrates 
D)  endogenous/factor VIII concentrates 
A)  exogenous/DDAVP 
B)  endogenous/DDAVP 
C)  exogenous/factor VIII concentrates 
D)  endogenous/factor VIII concentrates

Question 11

How can GVHD be prevented in transplant recipients?

Accepted Answer

A)  Filtering of cellular components 
B)  Irradiation of cellular components 
C)  Deglycerolizing of cellular components 
D)  None of the above 
A)  Filtering of cellular components 
B)  Irradiation of cellular components 
C)  Deglycerolizing of cellular components 
D)  None of the above

Question 12

How is donor platelet survival determined in the recipient?

Accepted Answer

A)  Platelet count increment (1 hour after transfusion) 
B)  Radiolabeled metals 
C)  Antiplatelet antibody detection 
D)  None of the above 
A)  Platelet count increment (1 hour after transfusion) 
B)  Radiolabeled metals 
C)  Antiplatelet antibody detection 
D)  None of the above

Question 13

Who is at risk for transfusion-associated graft-versus-host disease (TAGVHD)?

Accepted Answer

A)  Hodgkin's lymphoma patients 
B)  Bone marrow transplant recipients 
C)  Persons receiving nonirradiated directed donations 
D)  All of the above 
A)  Hodgkin's lymphoma patients 
B)  Bone marrow transplant recipients 
C)  Persons receiving nonirradiated directed donations 
D)  All of the above

Question 14

Factor VIII is treated by which of the following to ensure sterility for HIV and hepatitis B and C?

Accepted Answer

A)  Pasteurization 
B)  Nanofiltration 
C)  Solvent detergent 
D)  All of the above 
A)  Pasteurization 
B)  Nanofiltration 
C)  Solvent detergent 
D)  All of the above

Question 15

What does the first transfusion in a massive transfusion protocol consist of?

Accepted Answer

A)  2 units uncrossmatched group O whole blood 
B)  2 units uncrossmatched type-specific whole blood 
C)  2 units crossmatched group O whole blood 
D)  2 units crossmatched type-specific whole blood 
A)  2 units uncrossmatched group O whole blood 
B)  2 units uncrossmatched type-specific whole blood 
C)  2 units crossmatched group O whole blood 
D)  2 units crossmatched type-specific whole blood

Question 16

What component is indicated for patients who have had moderate to severe allergic transfusion reactions and have anti-IgA antibodies because of IgA deficiency?

Accepted Answer

A)  Whole blood 
B)  Packed RBCs 
C)  Washed RBCs 
D)  Granulocyte preparations 
A)  Whole blood 
B)  Packed RBCs 
C)  Washed RBCs 
D)  Granulocyte preparations

Question 17

Hemophilia A is clinically apparent when the factor VIII level is less than:

Accepted Answer

A)  20% 
B)  10% 
C)  50% 
D)  60% 
A)  20% 
B)  10% 
C)  50% 
D)  60%

Question 18

Which of the following is not a function of the hospital transfusion committee?

Accepted Answer

A)  FDA certification 
B)  Reviewing transfusion reactions 
C)  Submitting reports of committee recommendations to medical staff 
D)  Ensuring proper procedures are upheld by hospital personnel 
A)  FDA certification 
B)  Reviewing transfusion reactions 
C)  Submitting reports of committee recommendations to medical staff 
D)  Ensuring proper procedures are upheld by hospital personnel

Question 19

How are RBC aliquots prepared for a neonate transfusion?

Accepted Answer

A)  Blood is withdrawn from collection bag using a syringe and diluted 1:2 with saline. 
B)  Blood is withdrawn from collection bag using a syringe and diluted 1:2 with glycerol. 
C)  Blood is transferred from collection bag to satellite bag and withdrawn using a syringe. 
D)  None of the above 
A)  Blood is withdrawn from collection bag using a syringe and diluted 1:2 with saline. 
B)  Blood is withdrawn from collection bag using a syringe and diluted 1:2 with glycerol. 
C)  Blood is transferred from collection bag to satellite bag and withdrawn using a syringe. 
D)  None of the above

Question 20

Which of the following factors are found in therapeutic levels in fresh frozen plasma?

Accepted Answer

A)  Factor VIII 
B)  Factor V 
C)  Factor XI 
D)  All of the above 
A)  Factor VIII 
B)  Factor V 
C)  Factor XI 
D)  All of the above

Exam 16: Transfusion Therapy

Why is it essential that irradiated blood components be used in bone marrow transplant recipients?

What is the best-tolerated form of transplantation in humans?

Which of the following may be a serious manifestation of FFP transfusion in congenital factor deficiencies?

Which of the following criteria warrants a granulocyte concentrate transfusion?

What are the requirements for a transfusion to be classified as massive in an adult?

Cryoprecipitate AHF contains how much fibrinogen?

What hemoglobin level is considered critical and may warrant a red blood cell transfusion?

Factor IX concentrates contain which factors (otherwise known as "prothrombin complex")?

Liquid plasma is not indicated for factor deficiency.

Cryoprecipitated AHF can be used to treat von Willebrand's disease by providing vWF after has failed to release adequate amounts of endogenous vWF.

How can GVHD be prevented in transplant recipients?

How is donor platelet survival determined in the recipient?

Who is at risk for transfusion-associated graft-versus-host disease (TAGVHD)?

Factor VIII is treated by which of the following to ensure sterility for HIV and hepatitis B and C?

What does the first transfusion in a massive transfusion protocol consist of?

What component is indicated for patients who have had moderate to severe allergic transfusion reactions and have anti-IgA antibodies because of IgA deficiency?

Hemophilia A is clinically apparent when the factor VIII level is less than:

Which of the following is not a function of the hospital transfusion committee?

How are RBC aliquots prepared for a neonate transfusion?

Which of the following factors are found in therapeutic levels in fresh frozen plasma?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

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