Question 1

Which of the following is true for transferrin?

Accepted Answer

A)  It can bind two molecules of ferrous iron. 
B)  It binds to a transferrin receptor found on the cell membrane. 
C)  It is synthesized in the kidney. 
D)  It is normally about 50% saturated with iron. 
A)  It can bind two molecules of ferrous iron. 
B)  It binds to a transferrin receptor found on the cell membrane. 
C)  It is synthesized in the kidney. 
D)  It is normally about 50% saturated with iron. B

Question 2

Which of the following is true about iron absorption?

Accepted Answer

A)  It occurs primarily in the stomach. 
B)  Phytates and tannates enhance its absorption. 
C)  Ascorbic acid inhibits its absorption. 
D)  It must be in ferrous form for absorption. 
A)  It occurs primarily in the stomach. 
B)  Phytates and tannates enhance its absorption. 
C)  Ascorbic acid inhibits its absorption. 
D)  It must be in ferrous form for absorption. D

Question 3

Which of the following stains blue with the Prussian blue stain?

Accepted Answer

A)  Ferritin 
B)  Hemosiderin 
C)  Transferrin 
D)  Both ferritin and hemosiderin 
A)  Ferritin 
B)  Hemosiderin 
C)  Transferrin 
D)  Both ferritin and hemosiderin B

Question 4

Which two organs are the major storage sites for iron in a normal individual?

Accepted Answer

A)  Lymph nodes and muscle 
B)  Bone marrow and pancreas 
C)  Spleen and heart 
D)  Liver and spleen 
A)  Lymph nodes and muscle 
B)  Bone marrow and pancreas 
C)  Spleen and heart 
D)  Liver and spleen

Question 5

Heme is composed of iron and:

Accepted Answer

A)  Globin chains 
B)  Oxygen 
C)  Methemoglobin 
D)  Protoporphyrin IX 
A)  Globin chains 
B)  Oxygen 
C)  Methemoglobin 
D)  Protoporphyrin IX

Question 6

The serum iron and TIBC results given in Question 10 are consistent with:

Accepted Answer

A)  Iron overload 
B)  Iron toxicity 
C)  Iron deficiency 
D)  Acute infection 
A)  Iron overload 
B)  Iron toxicity 
C)  Iron deficiency 
D)  Acute infection

Question 7

Transferrin receptors can be measured and are elevated when:

Accepted Answer

A)  Erythropoietin increases. 
B)  Transferrin increases. 
C)  Iron stores are decreased. 
D)  Chronic disease is present. 
A)  Erythropoietin increases. 
B)  Transferrin increases. 
C)  Iron stores are decreased. 
D)  Chronic disease is present.

Question 8

A bone marrow Prussian blue stain shows blue granules inside of macrophages. What disorder can be ruled out by this result?

Accepted Answer

A)  Iron overload 
B)  Iron deficiency 
C)  Chronic disease 
D)  Lead poisoning 
A)  Iron overload 
B)  Iron deficiency 
C)  Chronic disease 
D)  Lead poisoning

Question 9

Where is the largest percentage of iron in the body located?

Accepted Answer

A)  Stored in the bone marrow 
B)  Stored in the liver 
C)  Attached to hemoglobin in erythrocytes 
D)  In the cytoplasm of macrophages 
A)  Stored in the bone marrow 
B)  Stored in the liver 
C)  Attached to hemoglobin in erythrocytes 
D)  In the cytoplasm of macrophages

Question 10

A patient has a serum iron of 10 g/dL and a total iron-binding capacity (TIBC) of 490 g/dL. What is the percent saturation of transferrin?

Accepted Answer

A)  2% 
B)  25% 
C)  40% 
D)  60% 
A)  2% 
B)  25% 
C)  40% 
D)  60%

Question 11

Which of the following is true regarding iron absorption?

Accepted Answer

A)  Vegetable nonheme iron is more easily absorbed than heme iron. 
B)  Most of the iron consumed is absorbed. 
C)  Ascorbic acid (vitamin 
C)  enhances absorption. 
D)  Those who are iron deficient absorb less iron. 
A)  Vegetable nonheme iron is more easily absorbed than heme iron. 
B)  Most of the iron consumed is absorbed. 
C)  Ascorbic acid (vitamin 
C)  enhances absorption. 
D)  Those who are iron deficient absorb less iron.

Question 12

The proportion of hemosiderin to ferritin increases when:

Accepted Answer

A)  Iron stores increase. 
B)  Anemia is present. 
C)  Transferrin increases. 
D)  Erythropoietin increases. 
A)  Iron stores increase. 
B)  Anemia is present. 
C)  Transferrin increases. 
D)  Erythropoietin increases.

Question 13

What are hemosiderin and ferritin?

Accepted Answer

A)  Enzymes necessary for iron absorption 
B)  Carrier proteins for iron 
C)  Storage forms of iron 
D)  Iron regulatory chemicals 
A)  Enzymes necessary for iron absorption 
B)  Carrier proteins for iron 
C)  Storage forms of iron 
D)  Iron regulatory chemicals

Question 14

Why is it not advisable for people with adequate iron stores to take supplemental iron?

Accepted Answer

A)  Iron overload is a risk. 
B)  The RBC count will increase. 
C)  Erythropoietin will increase. 
D)  Severe anemia is a risk. 
A)  Iron overload is a risk. 
B)  The RBC count will increase. 
C)  Erythropoietin will increase. 
D)  Severe anemia is a risk.

Question 15

What is the plasma carrier protein for iron?

Accepted Answer

A)  Ferritin 
B)  Transferrin 
C)  Albumin 
D)  Hemosiderin 
A)  Ferritin 
B)  Transferrin 
C)  Albumin 
D)  Hemosiderin

Question 16

Good dietary sources of iron include all except:

Accepted Answer

A)  Meat 
B)  Fruit 
C)  Fortified flour 
D)  Legumes 
A)  Meat 
B)  Fruit 
C)  Fortified flour 
D)  Legumes

Question 17

The serum ferritin is used more often than bone marrow or liver biopsies to assess iron stores because it is:

Accepted Answer

A)  A more direct measurement 
B)  More accurate 
C)  More precise 
D)  Less invasive 
A)  A more direct measurement 
B)  More accurate 
C)  More precise 
D)  Less invasive

Question 18

What is the mechanism for iron toxicity if iron is present in excess amounts?

Accepted Answer

A)  Acts as a catalyst in forming free oxygen radicals 
B)  Impedes hematopoiesis 
C)  Reduces hemoglobin to methemoglobin 
D)  Interferes with globin synthesis 
A)  Acts as a catalyst in forming free oxygen radicals 
B)  Impedes hematopoiesis 
C)  Reduces hemoglobin to methemoglobin 
D)  Interferes with globin synthesis

Question 19

A congenital deficiency of transferrin results in:

Accepted Answer

A)  Severe anemia 
B)  Reduced absorption of iron 
C)  Increased excretion of iron 
D)  Decreased storage of iron in organs 
A)  Severe anemia 
B)  Reduced absorption of iron 
C)  Increased excretion of iron 
D)  Decreased storage of iron in organs

Exam 11: Iron Metabolism

Which of the following is true for transferrin?

Which of the following is true about iron absorption?

Which of the following stains blue with the Prussian blue stain?

Which two organs are the major storage sites for iron in a normal individual?

Heme is composed of iron and:

The serum iron and TIBC results given in Question 10 are consistent with:

Transferrin receptors can be measured and are elevated when:

A bone marrow Prussian blue stain shows blue granules inside of macrophages. What disorder can be ruled out by this result?

Where is the largest percentage of iron in the body located?

A patient has a serum iron of 10 g/dL and a total iron-binding capacity (TIBC) of 490 g/dL. What is the percent saturation of transferrin?

Which of the following is true regarding iron absorption?

The proportion of hemosiderin to ferritin increases when:

What are hemosiderin and ferritin?

Why is it not advisable for people with adequate iron stores to take supplemental iron?

What is the plasma carrier protein for iron?

Good dietary sources of iron include all except:

The serum ferritin is used more often than bone marrow or liver biopsies to assess iron stores because it is:

What is the mechanism for iron toxicity if iron is present in excess amounts?

A congenital deficiency of transferrin results in:

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

Filters