Question 1

The most useful classification system for acute lymphoblastic leukemia based is based on:

Accepted Answer

A)  Immunophenotyping 
B)  Morphology 
C)  PAS staining 
D)  Sudan black B staining 
A)  Immunophenotyping 
B)  Morphology 
C)  PAS staining 
D)  Sudan black B staining A

Question 2

Which of the following is true regarding the symptoms of acute leukemia?

Accepted Answer

A)  Lymphadenopathy is found more often in myeloid than lymphoid. 
B)  Central nervous system involvement is the most common presenting symptom. 
C)  Most symptoms are related to abnormal cell counts. 
D)  Bone pain results from fractures related to calcium loss. 
A)  Lymphadenopathy is found more often in myeloid than lymphoid. 
B)  Central nervous system involvement is the most common presenting symptom. 
C)  Most symptoms are related to abnormal cell counts. 
D)  Bone pain results from fractures related to calcium loss. C

Question 3

An adult patient has a white blood count of 80 * 109/L. The differential has 92% Sudan black B-positive blasts and 8% lymphocytes. Which of the following is most likely?

Accepted Answer

A)  Acute myeloid leukemia, minimally differentiated 
B)  Acute myeloid leukemia without maturation 
C)  Immature B-cell acute lymphoblastic leukemia 
D)  Acute megakaryocytic leukemia 
A)  Acute myeloid leukemia, minimally differentiated 
B)  Acute myeloid leukemia without maturation 
C)  Immature B-cell acute lymphoblastic leukemia 
D)  Acute megakaryocytic leukemia B

Question 4

A 15-year-old boy is complaining of severe headaches; he has a white count of 76.0 *109/L, platelet count of 55 * 109/L, and a hematocrit of 33%. When a white cell differential is performed, most of the nucleated cells are blasts. They are CD2, CD4, and CD8 positive. What is the most likely diagnosis?

Accepted Answer

A)  Immature-B cell acute lymphoblastic leukemia 
B)  T-cell acute lymphoblastic leukemia 
C)  Acute myeloid leukemia without maturation 
D)  Acute myeloid leukemia with maturation 
A)  Immature-B cell acute lymphoblastic leukemia 
B)  T-cell acute lymphoblastic leukemia 
C)  Acute myeloid leukemia without maturation 
D)  Acute myeloid leukemia with maturation

Question 5

A 47-year-old man has gingival hypertrophy and a white blood cell (WBC) count of 108 *109/L. He has a moderate anemia and is thrombocytopenic. The differential consists primarily of a combination of mature monocytes, promonocytes, and CD14-positive blasts. Which of the following forms of acute myeloid leukemia is most likely?

Accepted Answer

A)  Acute myeloid leukemia with maturation 
B)  Acute myeloid leukemia with t(15;17)(q22:q12) 
C)  Acute monoblastic leukemia 
D)  Acute myeloid leukemia with minimal differentiation 
A)  Acute myeloid leukemia with maturation 
B)  Acute myeloid leukemia with t(15;17)(q22:q12) 
C)  Acute monoblastic leukemia 
D)  Acute myeloid leukemia with minimal differentiation

Question 6

Acute myelomonocytic leukemia is positive for which of the following?

Accepted Answer

A)  CALLa (CD10) 
B)  Periodic acid-Schiff (PAS) 
C)  HLA-DR1a 
D)  CD13 and CD14 
A)  CALLa (CD10) 
B)  Periodic acid-Schiff (PAS) 
C)  HLA-DR1a 
D)  CD13 and CD14

Question 7

Which of the following indicates a favorable prognosis in acute lymphoblastic leukemia?

Accepted Answer

A)  Chromosal translocations 
B)  Low white count at diagnosis 
C)  Patient older than 45 years old 
D)  T-cell immunophenotype 
A)  Chromosal translocations 
B)  Low white count at diagnosis 
C)  Patient older than 45 years old 
D)  T-cell immunophenotype

Question 8

A child has monotonous blasts in the peripheral blood that have scant blue cytoplasm. They are cALLa (CD10) positive. Which form of acute lymphoblastic leukemia is most likely?

Accepted Answer

A)  Immature B cell 
B)  Immature T cell 
C)  Mature B cell 
D)  Mature T cell 
A)  Immature B cell 
B)  Immature T cell 
C)  Mature B cell 
D)  Mature T cell

Question 9

What is the most common leukemia in children between the ages of 2 and 10 years?

Accepted Answer

A)  Acute myeloid 
B)  Acute monocytic 
C)  Acute myelomonocytic 
D)  Acute lymphoblastic 
A)  Acute myeloid 
B)  Acute monocytic 
C)  Acute myelomonocytic 
D)  Acute lymphoblastic

Question 10

A 27-year-old woman arrives at the emergency department with acute bleeding and is found to have a white count of 25.7 *109L with pancytopenia: hematocrit 27%, platelet count 35*109/L, and absolute neutrophil count 0.8 * 109/L. She has a combination of 97% blasts and abnormal promyelocytes in her peripheral blood; some of these cells contain stacked Auer rods. What form of leukemia does she most likely have?

Accepted Answer

A)  Acute myeloid leukemia with t(15;17)(q22:q12) 
B)  Chronic myeloid leukemia 
C)  Acute monoblastic leukemia 
D)  Acute myeloid leukemia with t(8;21)(q33:q22) 
A)  Acute myeloid leukemia with t(15;17)(q22:q12) 
B)  Chronic myeloid leukemia 
C)  Acute monoblastic leukemia 
D)  Acute myeloid leukemia with t(8;21)(q33:q22)

Question 11

Which form of acute myeloid leukemia is most often associated with disseminated intravascular coagulation (DIC)?

Accepted Answer

A)  Acute myeloid leukemia minimally differentiated 
B)  Acute myeloid leukemia with t(8;21)(q33:q22) 
C)  Acute myeloid leukemia with t(15;17)(q22:q12) 
D)  Acute myeloid leukemia with maturation 
A)  Acute myeloid leukemia minimally differentiated 
B)  Acute myeloid leukemia with t(8;21)(q33:q22) 
C)  Acute myeloid leukemia with t(15;17)(q22:q12) 
D)  Acute myeloid leukemia with maturation

Question 12

What leukemia is most likely in a patient whose bone marrow is composed of predominantly large, multinucleated, dysplastic erythroid precursors?

Accepted Answer

A)  Acute myelomonocytic leukemia 
B)  Acute megakaryocytic leukemia 
C)  Acute erythroleukemia 
D)  Acute myeloid leukemia with minimal maturation 
A)  Acute myelomonocytic leukemia 
B)  Acute megakaryocytic leukemia 
C)  Acute erythroleukemia 
D)  Acute myeloid leukemia with minimal maturation

Question 13

Which form of acute myeloid leukemia has megakaryoblasts and antibodies to platelet glycoprotein IIb/IIIa?

Accepted Answer

A)  Acute myeloid leukemia with minimal differentiation 
B)  Acute monoblastic leukemia 
C)  Acute erythroleukemia 
D)  Acute megakaryocytic leukemia 
A)  Acute myeloid leukemia with minimal differentiation 
B)  Acute monoblastic leukemia 
C)  Acute erythroleukemia 
D)  Acute megakaryocytic leukemia

Exam 36: Acute Leukemias

The most useful classification system for acute lymphoblastic leukemia based is based on:

Which of the following is true regarding the symptoms of acute leukemia?

An adult patient has a white blood count of 80 * 109/L. The differential has 92% Sudan black B-positive blasts and 8% lymphocytes. Which of the following is most likely?

Acute myelomonocytic leukemia is positive for which of the following?

Which of the following indicates a favorable prognosis in acute lymphoblastic leukemia?

A child has monotonous blasts in the peripheral blood that have scant blue cytoplasm. They are cALLa (CD10) positive. Which form of acute lymphoblastic leukemia is most likely?

What is the most common leukemia in children between the ages of 2 and 10 years?

Which form of acute myeloid leukemia is most often associated with disseminated intravascular coagulation (DIC)?

What leukemia is most likely in a patient whose bone marrow is composed of predominantly large, multinucleated, dysplastic erythroid precursors?

Which form of acute myeloid leukemia has megakaryoblasts and antibodies to platelet glycoprotein IIb/IIIa?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

Filters

An adult patient has a white blood count of 80 * 10⁹/L. The differential has 92% Sudan black B-positive blasts and 8% lymphocytes. Which of the following is most likely?