Question 1

Enlarged lymph nodes are commonly found in all of the following except:

Accepted Answer

A)  Viral infections 
B)  Liver cirrhosis 
C)  Bacterial infections 
D)  Metastatic malignancy 
A)  Viral infections 
B)  Liver cirrhosis 
C)  Bacterial infections 
D)  Metastatic malignancy B

Question 2

When hematopoiesis occurs in the liver in an adult, it is called:

Accepted Answer

A)  Intramedullary 
B)  Intermedullary 
C)  Normal 
D)  Extramedullary 
A)  Intramedullary 
B)  Intermedullary 
C)  Normal 
D)  Extramedullary D

Question 3

Where are developing red cells located in the bone marrow?

Accepted Answer

A)  Adjacent to the outer surfaces of the vascular sinuses 
B)  Outside the vascular walls of the sinusoids 
C)  Deep in the cords 
D)  Randomly spaced throughout the cords 
A)  Adjacent to the outer surfaces of the vascular sinuses 
B)  Outside the vascular walls of the sinusoids 
C)  Deep in the cords 
D)  Randomly spaced throughout the cords A

Question 4

What is the primary mechanism for the anemia associated with kidney disease?

Accepted Answer

A)  Hemolysis 
B)  Hemorrhage 
C)  Inadequate synthesis of erythropoietin 
D)  Inadequate synthesis of interleukins 
A)  Hemolysis 
B)  Hemorrhage 
C)  Inadequate synthesis of erythropoietin 
D)  Inadequate synthesis of interleukins

Question 5

Why does surgical removal of the spleen cause people to have an increased platelet count?

Accepted Answer

A)  The bone marrow makes more platelets when the person has no spleen. 
B)  The 30% of platelets normally stored in the spleen are freely circulating. 
C)  Antibodies produced after splenectomy attack platelets. 
D)  Surgery stimulates platelet growth factors. 
A)  The bone marrow makes more platelets when the person has no spleen. 
B)  The 30% of platelets normally stored in the spleen are freely circulating. 
C)  Antibodies produced after splenectomy attack platelets. 
D)  Surgery stimulates platelet growth factors.

Question 6

All of the following are functions of macrophages in the bone marrow except:

Accepted Answer

A)  Activating adipose cells 
B)  Secreting cytokines 
C)  Storing iron 
D)  Phagocytizing senescent cells 
A)  Activating adipose cells 
B)  Secreting cytokines 
C)  Storing iron 
D)  Phagocytizing senescent cells

Question 7

What are the major hematopoietic sites in the fetus and in the adult? Fetus Adult

Accepted Answer

A)  Lymph nodes Spleen 
B)  Liver Bone marrow 
C)  Liver Spleen 
D)  Bone marrow Liver 
A)  Lymph nodes Spleen 
B)  Liver Bone marrow 
C)  Liver Spleen 
D)  Bone marrow Liver

Question 8

Colony stimulating factors:

Accepted Answer

A)  Have poor affinity for their target cells 
B)  Require high concentrations to be effective 
C)  Are produced by many cells 
D)  Are all lineage specific 
A)  Have poor affinity for their target cells 
B)  Require high concentrations to be effective 
C)  Are produced by many cells 
D)  Are all lineage specific

Question 9

Apoptosis is:

Accepted Answer

A)  Enhanced red cell production 
B)  Programmed cell death 
C)  Directed exit of cells from the bone marrow 
D)  Accidental cell death from trauma 
A)  Enhanced red cell production 
B)  Programmed cell death 
C)  Directed exit of cells from the bone marrow 
D)  Accidental cell death from trauma

Question 10

Why are erythrocyte cellular inclusions such as Howell-Jolly bodies found after surgical removal of the spleen?

Accepted Answer

A)  Blood loss from surgery increases erythrocyte production. 
B)  Necessary hematopoiesis growth factors produced in the spleen are lost. 
C)  Removal of the spleen induces the formation of inclusions. 
D)  The absent spleen cannot "pit" or remove the normally formed inclusions. 
A)  Blood loss from surgery increases erythrocyte production. 
B)  Necessary hematopoiesis growth factors produced in the spleen are lost. 
C)  Removal of the spleen induces the formation of inclusions. 
D)  The absent spleen cannot "pit" or remove the normally formed inclusions.

Question 11

Germinal centers in lymph nodes contain primarily:

Accepted Answer

A)  B cells 
B)  Macrophages 
C)  Neutrophils 
D)  T cells 
A)  B cells 
B)  Macrophages 
C)  Neutrophils 
D)  T cells

Question 12

The thymus is responsible for the initial development of:

Accepted Answer

A)  Macrophages 
B)  T cells 
C)  B cells 
D)  Neutrophils 
A)  Macrophages 
B)  T cells 
C)  B cells 
D)  Neutrophils

Question 13

How many blood cells are made each day in the bone marrow of a normal adult?

Accepted Answer

A)  Thousands 
B)  Millions 
C)  About 1 billion 
D)  Hundreds of billions 
A)  Thousands 
B)  Millions 
C)  About 1 billion 
D)  Hundreds of billions

Question 14

What bone marrow cells can differentiate into all of the blood cells?

Accepted Answer

A)  Burst-forming unit-erythroid (BFU-
E)  
B)  Colony-forming unit-granulocyte-monocyte (CFU-GM) 
C)  Colony-forming unit-granulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM) 
D)  Hematopoietic stem cells (HSCs) 
A)  Burst-forming unit-erythroid (BFU-
E)  
B)  Colony-forming unit-granulocyte-monocyte (CFU-GM) 
C)  Colony-forming unit-granulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM) 
D)  Hematopoietic stem cells (HSCs)

Question 15

How do cells get from the bone marrow into peripheral circulation?

Accepted Answer

A)  Stem cells escape the bone marrow and mature in peripheral circulation. 
B)  Mature cells attach to a carrier protein for transport. 
C)  Capillaries flow into the marrow and pluck out precursor cells. 
D)  Mature cells squeeze through spaces in the vessel endothelial lining. 
A)  Stem cells escape the bone marrow and mature in peripheral circulation. 
B)  Mature cells attach to a carrier protein for transport. 
C)  Capillaries flow into the marrow and pluck out precursor cells. 
D)  Mature cells squeeze through spaces in the vessel endothelial lining.

Question 16

Which of the following is a hematopoietic growth factor?

Accepted Answer

A)  Interleukin 
B)  BFU-E 
C)  Fibroblast 
D)  HSC 
A)  Interleukin 
B)  BFU-E 
C)  Fibroblast 
D)  HSC

Question 17

All of the following functions are performed by cytokines except:

Accepted Answer

A)  Stimulating production of blood cells 
B)  Inducing macrophages to attack senescent cells 
C)  Regulating cell differentiation 
D)  Monitoring trafficking of mature blood cells 
A)  Stimulating production of blood cells 
B)  Inducing macrophages to attack senescent cells 
C)  Regulating cell differentiation 
D)  Monitoring trafficking of mature blood cells

Question 18

Which of the following, using Wright stain, is a feature of normal cells as they mature?

Accepted Answer

A)  Overall size increases 
B)  Nucleoli become more prominent 
C)  Nuclear chromatin becomes more condensed 
D)  Cytoplasmic basophilia increases 
A)  Overall size increases 
B)  Nucleoli become more prominent 
C)  Nuclear chromatin becomes more condensed 
D)  Cytoplasmic basophilia increases

Question 19

What condition is most associated with autosplenectomy?

Accepted Answer

A)  Abdominal trauma 
B)  Thrombocytopenia 
C)  Sickle cell anemia 
D)  Iron deficiency 
A)  Abdominal trauma 
B)  Thrombocytopenia 
C)  Sickle cell anemia 
D)  Iron deficiency

Question 20

Which of the following is a morphologically identifiable precursor cell using Wright stain?

Accepted Answer

A)  Promyelocyte 
B)  Colony-forming unit-erythrocyte (CFU-
E)  
C)  Colony-stimulating factor-granulocyte-monocyte (CSF-GM) 
D)  HSC 
A)  Promyelocyte 
B)  Colony-forming unit-erythrocyte (CFU-
E)  
C)  Colony-stimulating factor-granulocyte-monocyte (CSF-GM) 
D)  HSC

Exam 7: Hematopoiesis

Enlarged lymph nodes are commonly found in all of the following except:

When hematopoiesis occurs in the liver in an adult, it is called:

Where are developing red cells located in the bone marrow?

What is the primary mechanism for the anemia associated with kidney disease?

Why does surgical removal of the spleen cause people to have an increased platelet count?

All of the following are functions of macrophages in the bone marrow except:

What are the major hematopoietic sites in the fetus and in the adult? Fetus Adult

Colony stimulating factors:

Apoptosis is:

Why are erythrocyte cellular inclusions such as Howell-Jolly bodies found after surgical removal of the spleen?

Germinal centers in lymph nodes contain primarily:

The thymus is responsible for the initial development of:

How many blood cells are made each day in the bone marrow of a normal adult?

What bone marrow cells can differentiate into all of the blood cells?

How do cells get from the bone marrow into peripheral circulation?

Which of the following is a hematopoietic growth factor?

All of the following functions are performed by cytokines except:

Which of the following, using Wright stain, is a feature of normal cells as they mature?

What condition is most associated with autosplenectomy?

Which of the following is a morphologically identifiable precursor cell using Wright stain?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

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