Question 1

Which of the following are components of the contact group of factors?

Accepted Answer

A)  Fibrinogen and thrombin 
B)  VIII and VWF 
C)  XII and prekallikrein 
D)  Calcium and IX 
A)  Fibrinogen and thrombin 
B)  VIII and VWF 
C)  XII and prekallikrein 
D)  Calcium and IX C

Question 2

What happens to the fibrin monomers created when thrombin cleaves fibrinopeptides A and B from fibrinogen?

Accepted Answer

A)  Immediately inactivated to prevent excess clotting 
B)  Converted to plasminogen 
C)  Digested quickly by tissue plasminogen activator (TP
A)  
D)  Polymerize and are stabilized by factor XIIIa 
A)  Immediately inactivated to prevent excess clotting 
B)  Converted to plasminogen 
C)  Digested quickly by tissue plasminogen activator (TP
A)  
D)  Polymerize and are stabilized by factor XIIIa D

Question 3

What substance digests the fibrin clot after healing?

Accepted Answer

A)  Plasmin 
B)  Activated protein C 
C)  TPA 
D)  ($\alpha$2-Antiplasmin) 
A)  Plasmin 
B)  Activated protein C 
C)  TPA 
D)  ($\alpha$2-Antiplasmin) A

Question 4

Which of the following is the most important protease of the coagulation pathway because of its role in so many different catalytic functions?

Accepted Answer

A)  Thrombin 
B)  Factor XIa 
C)  Plasmin 
D)  Factor VIIa 
A)  Thrombin 
B)  Factor XIa 
C)  Plasmin 
D)  Factor VIIa

Question 5

Which of the following is true regarding the plasma coagulation zymogens?

Accepted Answer

A)  Circulate normally in their active form 
B)  Are serine proteases that digest peptide bonds creating a new active factor 
C)  Activation normally occurs throughout the body when vascular injury occurs 
D)  Are cofactors that induce peptide bonding to make larger active molecules 
A)  Circulate normally in their active form 
B)  Are serine proteases that digest peptide bonds creating a new active factor 
C)  Activation normally occurs throughout the body when vascular injury occurs 
D)  Are cofactors that induce peptide bonding to make larger active molecules

Question 6

All of the following are functions of thrombin except:

Accepted Answer

A)  Activates factors V and VIII 
B)  Activates plasminogen 
C)  Activates factor XIII 
D)  Initiates platelet aggregation 
A)  Activates factors V and VIII 
B)  Activates plasminogen 
C)  Activates factor XIII 
D)  Initiates platelet aggregation

Question 7

What is the role of the thrombin-thrombomodulin complex?

Accepted Answer

A)  Initiates vasoconstriction 
B)  Activates thrombin 
C)  Inhibits factor Xa 
D)  Activates protein C 
A)  Initiates vasoconstriction 
B)  Activates thrombin 
C)  Inhibits factor Xa 
D)  Activates protein C

Question 8

Which of the following therapies actually lyses the clot rather than prevents future clots?

Accepted Answer

A)  Aspirin 
B)  Heparin 
C)  TPA 
D)  Coumadin 
A)  Aspirin 
B)  Heparin 
C)  TPA 
D)  Coumadin

Question 9

Which of the following is part of primary hemostasis?

Accepted Answer

A)  Fibrinolysis 
B)  Blood vessels 
C)  Intrinsic system 
D)  Inhibitors 
A)  Fibrinolysis 
B)  Blood vessels 
C)  Intrinsic system 
D)  Inhibitors

Question 10

What are the primary procoagulant roles of the blood vessel?

Accepted Answer

A)  Constrict and provide collagen and other compounds to activate clotting 
B)  Prevent the blood from escaping and promote fibrinolysis 
C)  Secrete platelet growth factors and manufacture calcium 
D)  Constrict and synthesize most plasma coagulation factors 
A)  Constrict and provide collagen and other compounds to activate clotting 
B)  Prevent the blood from escaping and promote fibrinolysis 
C)  Secrete platelet growth factors and manufacture calcium 
D)  Constrict and synthesize most plasma coagulation factors

Question 11

Which of the following aids in preventing excess clotting?

Accepted Answer

A)  Thrombin 
B)  Factor VII 
C)  Nitric oxide 
D)  Protein C 
A)  Thrombin 
B)  Factor VII 
C)  Nitric oxide 
D)  Protein C

Question 12

Which of the following is necessary for platelet aggregation?

Accepted Answer

A)  Protein S 
B)  Kallikrein 
C)  Vitamin K 
D)  Fibrinogen 
A)  Protein S 
B)  Kallikrein 
C)  Vitamin K 
D)  Fibrinogen

Question 13

Patients who have a deficiency of protein C or protein S have which type of disorder?

Accepted Answer

A)  Bleeding disorder 
B)  Thrombotic disorder 
C)  Bruising disorder 
D)  Hypercalcemia 
A)  Bleeding disorder 
B)  Thrombotic disorder 
C)  Bruising disorder 
D)  Hypercalcemia

Question 14

Absence of D dimers is useful for ruling out:

Accepted Answer

A)  Deep venous thrombosis 
B)  von Willebrand disease (VW
D)  
C)  Protein C deficiency 
D)  Factor VII deficiency 
A)  Deep venous thrombosis 
B)  von Willebrand disease (VW
D)  
C)  Protein C deficiency 
D)  Factor VII deficiency

Question 15

Oral anticoagulation is based on:

Accepted Answer

A)  Increasing plasminogen 
B)  Activating plasmin 
C)  Combining with antithrombin 
D)  Vitamin K antagonism 
A)  Increasing plasminogen 
B)  Activating plasmin 
C)  Combining with antithrombin 
D)  Vitamin K antagonism

Question 16

Where are most of the plasma procoagulant proteins produced?

Accepted Answer

A)  Liver 
B)  Megakaryocytes 
C)  Endothelial cells 
D)  Spleen 
A)  Liver 
B)  Megakaryocytes 
C)  Endothelial cells 
D)  Spleen

Question 17

What vitamin is essential for normal synthesis of prothrombin group proteins, thus enabling them to bind Ca2+?

Accepted Answer

A)  Vitamin K 
B)  Vitamin B12 
C)  Vitamin C 
D)  Vitamin D 
A)  Vitamin K 
B)  Vitamin B12 
C)  Vitamin C 
D)  Vitamin D

Question 18

What substance is known to inactivate cyclooxygenase, causing impairment of platelet function?

Accepted Answer

A)  Aspirin 
B)  Calcium 
C)  Tylenol 
D)  Vitamin K 
A)  Aspirin 
B)  Calcium 
C)  Tylenol 
D)  Vitamin K

Question 19

What plasma protein is important for normal wound healing and stabilization of the fibrin clot?

Accepted Answer

A)  Tissue factor 
B)  Prothrombin 
C)  Factor Xa 
D)  Factor XIIIa 
A)  Tissue factor 
B)  Prothrombin 
C)  Factor Xa 
D)  Factor XIIIa

Question 20

What protein does heparin work with to inhibit coagulation?

Accepted Answer

A)  Protein S 
B)  Antithrombin 
C)  Vitamin K 
D)  Factor VII 
A)  Protein S 
B)  Antithrombin 
C)  Vitamin K 
D)  Factor VII

Exam 40: Normal Hemostasis and Coagulation

Which of the following are components of the contact group of factors?

What happens to the fibrin monomers created when thrombin cleaves fibrinopeptides A and B from fibrinogen?

What substance digests the fibrin clot after healing?

Which of the following is the most important protease of the coagulation pathway because of its role in so many different catalytic functions?

Which of the following is true regarding the plasma coagulation zymogens?

All of the following are functions of thrombin except:

What is the role of the thrombin-thrombomodulin complex?

Which of the following therapies actually lyses the clot rather than prevents future clots?

Which of the following is part of primary hemostasis?

What are the primary procoagulant roles of the blood vessel?

Which of the following aids in preventing excess clotting?

Which of the following is necessary for platelet aggregation?

Patients who have a deficiency of protein C or protein S have which type of disorder?

Absence of D dimers is useful for ruling out:

Oral anticoagulation is based on:

Where are most of the plasma procoagulant proteins produced?

What vitamin is essential for normal synthesis of prothrombin group proteins, thus enabling them to bind Ca2+?

What substance is known to inactivate cyclooxygenase, causing impairment of platelet function?

What plasma protein is important for normal wound healing and stabilization of the fibrin clot?

What protein does heparin work with to inhibit coagulation?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

Filters

What vitamin is essential for normal synthesis of prothrombin group proteins, thus enabling them to bind Ca²⁺?