Question 1

What is the greatest drawback to autologous over allogeneic stem cell transplant for leukemia?

Accepted Answer

A)  Graft-versus-host disease (GVH
D)  
B)  Infections 
C)  Bleeding 
D)  Malignant cells more likely to return 
A)  Graft-versus-host disease (GVH
D)  
B)  Infections 
C)  Bleeding 
D)  Malignant cells more likely to return D

Question 2

What cell process is normally responsible for removal of redundant, damaged, aged, or defective cells?

Accepted Answer

A)  Apoptosis 
B)  Repression 
C)  Translocation 
D)  Progression 
A)  Apoptosis 
B)  Repression 
C)  Translocation 
D)  Progression A

Question 3

Hematopoietic stem cells can be harvested from all of the following tissues except:

Accepted Answer

A)  Bone marrow 
B)  Umbilical cord blood 
C)  Liver 
D)  Peripheral blood 
A)  Bone marrow 
B)  Umbilical cord blood 
C)  Liver 
D)  Peripheral blood C

Question 4

GVHD develops when:

Accepted Answer

A)  Donor T cells attack patient tissue or tissues. 
B)  Patient T cells attack donor stem cells. 
C)  Donor B cells attack patient tissue or tissues. 
D)  Patient B cells attack donor stem cells. 
A)  Donor T cells attack patient tissue or tissues. 
B)  Patient T cells attack donor stem cells. 
C)  Donor B cells attack patient tissue or tissues. 
D)  Patient B cells attack donor stem cells.

Question 5

What chromosomal translocation is associated with chronic myelogenous leukemia?

Accepted Answer

A)  t(9;22) 
B)  t(6;14) 
C)  t(1;22) 
D)  t(9;14) 
A)  t(9;22) 
B)  t(6;14) 
C)  t(1;22) 
D)  t(9;14)

Question 6

A proto-oncogene codes for a protein involved in cell:

Accepted Answer

A)  Differentiation 
B)  Nuclear shape 
C)  Cycle regulation 
D)  Lipid metabolism 
A)  Differentiation 
B)  Nuclear shape 
C)  Cycle regulation 
D)  Lipid metabolism

Question 7

Viruses have been found as a causative agent for which of the following hematologic malignancies?

Accepted Answer

A)  Burkitt lymphoma 
B)  Chronic myelogenous leukemia 
C)  Hairy cell leukemia 
D)  Acute myeloid leukemia 
A)  Burkitt lymphoma 
B)  Chronic myelogenous leukemia 
C)  Hairy cell leukemia 
D)  Acute myeloid leukemia

Question 8

Which of the following is true concerning the use of chemotherapeutic drugs?

Accepted Answer

A)  Affects only neoplastic cells in cell cycle 
B)  Dosage limited by the effect on normal bone marrow cells 
C)  Affects only neoplastic cells 
D)  Dosage limited by the effect on neoplastic cells 
A)  Affects only neoplastic cells in cell cycle 
B)  Dosage limited by the effect on normal bone marrow cells 
C)  Affects only neoplastic cells 
D)  Dosage limited by the effect on neoplastic cells

Question 9

What is the major drawback to chemotherapy?

Accepted Answer

A)  Makes the patient feel so bad 
B)  High cost of drug and long hospital stays 
C)  Requires extensive laboratory monitoring 
D)  Suppression of the bone marrow 
A)  Makes the patient feel so bad 
B)  High cost of drug and long hospital stays 
C)  Requires extensive laboratory monitoring 
D)  Suppression of the bone marrow

Question 10

How do chemotherapy drugs work to kill or inhibit tumor cells?

Accepted Answer

A)  Increase apoptosis 
B)  Create holes in the cell surfaces 
C)  Variety of mechanisms can damage deoxyribonucleic acid (DN
A)  or interfere with the cell cycle 
D)  Interfere with protein synthesis 
A)  Increase apoptosis 
B)  Create holes in the cell surfaces 
C)  Variety of mechanisms can damage deoxyribonucleic acid (DN
A)  or interfere with the cell cycle 
D)  Interfere with protein synthesis

Question 11

Most malignancies of the hematopoietic system are an:

Accepted Answer

A)  Inherited autosomal disease 
B)  Acquired infectious disease 
C)  Inherited X-linked disease 
D)  Acquired genetic disease 
A)  Inherited autosomal disease 
B)  Acquired infectious disease 
C)  Inherited X-linked disease 
D)  Acquired genetic disease

Question 12

What laboratory tests are used to diagnose and classify leukemia?

Accepted Answer

A)  Microscopic evaluation of peripheral blood and bone marrow 
B)  Cytochemical staining and immunologic study of bone marrow cells 
C)  Cytogenetic techniques 
D)  All of the above 
A)  Microscopic evaluation of peripheral blood and bone marrow 
B)  Cytochemical staining and immunologic study of bone marrow cells 
C)  Cytogenetic techniques 
D)  All of the above

Question 13

Imatinib mesylate is an example of:

Accepted Answer

A)  Cell cycle specific chemotherapy 
B)  An oncogene 
C)  Targeted therapy 
D)  A tumor suppressor gene 
A)  Cell cycle specific chemotherapy 
B)  An oncogene 
C)  Targeted therapy 
D)  A tumor suppressor gene

Question 14

Which of the following malignancies has the greatest chance for long-term survival or cure?

Accepted Answer

A)  Chronic myelogenous leukemia 
B)  Chronic lymphocytic leukemia 
C)  Therapy-related leukemia 
D)  Mantle cell lymphoma 
A)  Chronic myelogenous leukemia 
B)  Chronic lymphocytic leukemia 
C)  Therapy-related leukemia 
D)  Mantle cell lymphoma

Exam 29: Introduction to Leukocyte Neoplasms

What is the greatest drawback to autologous over allogeneic stem cell transplant for leukemia?

What cell process is normally responsible for removal of redundant, damaged, aged, or defective cells?

Hematopoietic stem cells can be harvested from all of the following tissues except:

GVHD develops when:

What chromosomal translocation is associated with chronic myelogenous leukemia?

A proto-oncogene codes for a protein involved in cell:

Viruses have been found as a causative agent for which of the following hematologic malignancies?

Which of the following is true concerning the use of chemotherapeutic drugs?

What is the major drawback to chemotherapy?

How do chemotherapy drugs work to kill or inhibit tumor cells?

Most malignancies of the hematopoietic system are an:

What laboratory tests are used to diagnose and classify leukemia?

Imatinib mesylate is an example of:

Which of the following malignancies has the greatest chance for long-term survival or cure?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

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