Question 1

Which of the following is true regarding testing for the diagnosis of vascular disorders?

Accepted Answer

A)  Most do not have abnormal clinical laboratory tests. 
B)  The platelet count and aggregometry are useful. 
C)  The prothrombin time (PT) and partial thromboplastin time (PTT) are most useful. 
D)  Evaluation of von Willebrand factor (VWF) is useful. 
A)  Most do not have abnormal clinical laboratory tests. 
B)  The platelet count and aggregometry are useful. 
C)  The prothrombin time (PT) and partial thromboplastin time (PTT) are most useful. 
D)  Evaluation of von Willebrand factor (VWF) is useful. A

Question 2

Platelet count and function studies are performed on a patient with a history of easy bruising, and the following results are obtained: 
 
What is the most likely diagnosis for this patient?

Accepted Answer

A)  Bernard-Soulier disease 
B)  Dense granule deficiency 
C)  Glanzmann thrombasthenia 
D)  Gray platelet syndrome 
A)  Bernard-Soulier disease 
B)  Dense granule deficiency 
C)  Glanzmann thrombasthenia 
D)  Gray platelet syndrome B

Question 3

Which of the following is the most likely diagnosis for a patient with a normal platelet count, prolonged bleeding time, and no aggregation with any agent except ristocetin?

Accepted Answer

A)  Aspirin ingestion 
B)  Gray platelet syndrome 
C)  Vitamin C deficiency 
D)  Glanzmann thrombasthenia 
A)  Aspirin ingestion 
B)  Gray platelet syndrome 
C)  Vitamin C deficiency 
D)  Glanzmann thrombasthenia D

Question 4

Which of the following is a disorder with absent platelet glycoprotein Ib/IX/V and in which the patient has moderate thrombocytopenia, large platelets, and normal aggregometry with all agents except ristocetin?

Accepted Answer

A)  von Willebrand disorder (VW
D)  
B)  Bernard-Soulier syndrome 
C)  Glanzmann thrombasthenia 
D)  Dense granule deficiency 
A)  von Willebrand disorder (VW
D)  
B)  Bernard-Soulier syndrome 
C)  Glanzmann thrombasthenia 
D)  Dense granule deficiency

Question 5

A 78-year-old patient recently noticed dark blotches on his forearms and on the backs of his hands. He seems to bruise even when a phlebotomy is performed using excellent technique with no problems encountered. No other symptoms exist, and all laboratory tests are normal. Which of the following is the most likely diagnosis?

Accepted Answer

A)  Hereditary hemorrhagic telangiectasia 
B)  Ehlers-Danlos syndrome 
C)  Paraproteinemia and amyloidosis 
D)  Senile purpura 
A)  Hereditary hemorrhagic telangiectasia 
B)  Ehlers-Danlos syndrome 
C)  Paraproteinemia and amyloidosis 
D)  Senile purpura

Question 6

Clopidogrel is a drug used therapeutically for patients with a risk of arterial thrombi because it:

Accepted Answer

A)  Inhibits thrombin 
B)  Activates the protein C pathway 
C)  Inhibits platelet function 
D)  Activates plasminogen 
A)  Inhibits thrombin 
B)  Activates the protein C pathway 
C)  Inhibits platelet function 
D)  Activates plasminogen

Question 7

The qualitative platelet disorders and vascular disorders typically exhibit what type of symptoms?

Accepted Answer

A)  Superficial bleeding 
B)  Deep tissue bleeding 
C)  Hemarthrosis 
D)  Thrombosis 
A)  Superficial bleeding 
B)  Deep tissue bleeding 
C)  Hemarthrosis 
D)  Thrombosis

Question 8

All of the following are common conditions or situations that interfere with platelet function except:

Accepted Answer

A)  Liver disease 
B)  Uremia 
C)  Allergic purpura 
D)  Cardiopulmonary bypass surgery 
A)  Liver disease 
B)  Uremia 
C)  Allergic purpura 
D)  Cardiopulmonary bypass surgery

Question 9

Which of the following is normal in a patient regularly taking aspirin?

Accepted Answer

A)  Bleeding time 
B)  Platelet cyclooxygenase function 
C)  Synthesis of thromboxane A2 
D)  Platelet count 
A)  Bleeding time 
B)  Platelet cyclooxygenase function 
C)  Synthesis of thromboxane A2 
D)  Platelet count

Question 10

What types of hemostatic complications are found in patients with myeloproliferative disorders?

Accepted Answer

A)  Hemorrhagic 
B)  Thrombotic 
C)  Abnormal platelet function 
D)  All of the above 
A)  Hemorrhagic 
B)  Thrombotic 
C)  Abnormal platelet function 
D)  All of the above

Question 11

Which of the following is normal in primary dense granule deficiency?

Accepted Answer

A)  Platelet count 
B)  Bleeding time 
C)  Platelet aggregometry 
D)  Platelet morphology 
A)  Platelet count 
B)  Bleeding time 
C)  Platelet aggregometry 
D)  Platelet morphology

Question 12

Which of the following is the most common cause of acquired platelet dysfunction?

Accepted Answer

A)  Myeloproliferative disorders 
B)  Wiskott-Aldrich syndrome 
C)  Drugs, especially aspirin 
D)  Afibrinogenemia 
A)  Myeloproliferative disorders 
B)  Wiskott-Aldrich syndrome 
C)  Drugs, especially aspirin 
D)  Afibrinogenemia

Question 13

What is the mechanism for the platelet dysfunction in multiple myeloma and Waldenström macroglobulinemia?

Accepted Answer

A)  Granules become deficient. 
B)  Platelets are coated with paraprotein. 
C)  Nitric oxide is not produced. 
D)  Cyclooxygenase is acetylated. 
A)  Granules become deficient. 
B)  Platelets are coated with paraprotein. 
C)  Nitric oxide is not produced. 
D)  Cyclooxygenase is acetylated.

Exam 44: Qualitative Disorders of Platelets and Vasculature

Which of the following is true regarding testing for the diagnosis of vascular disorders?

Platelet count and function studies are performed on a patient with a history of easy bruising, and the following results are obtained: What is the most likely diagnosis for this patient?

Which of the following is the most likely diagnosis for a patient with a normal platelet count, prolonged bleeding time, and no aggregation with any agent except ristocetin?

Which of the following is a disorder with absent platelet glycoprotein Ib/IX/V and in which the patient has moderate thrombocytopenia, large platelets, and normal aggregometry with all agents except ristocetin?

Clopidogrel is a drug used therapeutically for patients with a risk of arterial thrombi because it:

The qualitative platelet disorders and vascular disorders typically exhibit what type of symptoms?

All of the following are common conditions or situations that interfere with platelet function except:

Which of the following is normal in a patient regularly taking aspirin?

What types of hemostatic complications are found in patients with myeloproliferative disorders?

Which of the following is normal in primary dense granule deficiency?

Which of the following is the most common cause of acquired platelet dysfunction?

What is the mechanism for the platelet dysfunction in multiple myeloma and Waldenström macroglobulinemia?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

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