Question 1

Which of the following is an expected finding in MAHA?

Accepted Answer

A)  Elevated platelets 
B)  Schistocytes or red cell fragments 
C)  Low white count 
D)  Extravascular hemolysis 
A)  Elevated platelets 
B)  Schistocytes or red cell fragments 
C)  Low white count 
D)  Extravascular hemolysis B

Question 2

A patient has crescent- or banana-shaped malarial gametocytes. Which of the following is probably true regarding the species of malaria and its clinical course?

Accepted Answer

A)  Plasmodium malariae, which is benign and needs no treatment 
B)  Plasmodium ovale, which is found mostly in Southern United States and is usually fatal 
C)  Plasmodium falciparum, which is the most clinically serious 
D)  Plasmodium vivax, which is the most clinically serious 
A)  Plasmodium malariae, which is benign and needs no treatment 
B)  Plasmodium ovale, which is found mostly in Southern United States and is usually fatal 
C)  Plasmodium falciparum, which is the most clinically serious 
D)  Plasmodium vivax, which is the most clinically serious C

Question 3

Which of the following decreases the ability of malaria species to infect RBCs?

Accepted Answer

A)  Duffy-positive phenotype 
B)  Heterozygosity for hemoglobin S (Hb S) 
C)  Hereditary spherocytosis 
D)  Rh-negative genotype 
A)  Duffy-positive phenotype 
B)  Heterozygosity for hemoglobin S (Hb S) 
C)  Hereditary spherocytosis 
D)  Rh-negative genotype B

Question 4

Which of the following techniques most often diagnoses malaria and Babesia infections?

Accepted Answer

A)  Polymerase chain reaction (PCR) 
B)  Observing the organisms in blood films 
C)  Serologic tests 
D)  Culture 
A)  Polymerase chain reaction (PCR) 
B)  Observing the organisms in blood films 
C)  Serologic tests 
D)  Culture

Question 5

What is the pathogenesis of MAHA?

Accepted Answer

A)  Microthrombi and fibrin formed on damaged endothelial cells trap and break red cells. 
B)  Chemicals or heat destroy red blood cells (RBCs). 
C)  The spleen sequesters red cells in an attempt to remove abnormal inclusions. 
D)  Antibodies that activate complement are formed and destroy the red cell membrane. 
A)  Microthrombi and fibrin formed on damaged endothelial cells trap and break red cells. 
B)  Chemicals or heat destroy red blood cells (RBCs). 
C)  The spleen sequesters red cells in an attempt to remove abnormal inclusions. 
D)  Antibodies that activate complement are formed and destroy the red cell membrane.

Question 6

Why does Plasmodium falciparum infection result in the most serious hemolysis of the various forms of malaria?

Accepted Answer

A)  Only reticulocytes are invaded. 
B)  Reticulocytes and RBCs less than 10 days old are invaded. 
C)  Only mature RBCs are invaded. 
D)  RBCs of all ages are invaded. 
A)  Only reticulocytes are invaded. 
B)  Reticulocytes and RBCs less than 10 days old are invaded. 
C)  Only mature RBCs are invaded. 
D)  RBCs of all ages are invaded.

Question 7

All of the following are examples of microangiopathic hemolytic anemias (MAHAs) except:

Accepted Answer

A)  Thrombotic thrombocytopenia purpura 
B)  Hemolytic uremic syndrome 
C)  Disseminated intravascular coagulation (DI
C)  
D)  Immune thrombocytopenia purpura 
A)  Thrombotic thrombocytopenia purpura 
B)  Hemolytic uremic syndrome 
C)  Disseminated intravascular coagulation (DI
C)  
D)  Immune thrombocytopenia purpura

Question 8

A mild intravascular hemolytic anemia resulting from forceful repeated effect of the feet on hard surfaces is called:

Accepted Answer

A)  Traumatic cardiac hemolytic anemia 
B)  Exercise-induced hemoglobinuria 
C)  Bartonellosis 
D)  Thrombotic thrombocytopenic purpura 
A)  Traumatic cardiac hemolytic anemia 
B)  Exercise-induced hemoglobinuria 
C)  Bartonellosis 
D)  Thrombotic thrombocytopenic purpura

Question 9

A patient's red cells show globular fragmentation, budding, and microspherocytes. To what have the red cells probably been exposed?

Accepted Answer

A)  Heat 
B)  Chemicals 
C)  Oxidant drugs 
D)  Bartonellosis 
A)  Heat 
B)  Chemicals 
C)  Oxidant drugs 
D)  Bartonellosis

Question 10

Which of the following infections is responsible for the most deaths worldwide?

Accepted Answer

A)  Malaria 
B)  Babesia infection 
C)  Bartonella infection 
D)  Clostridial septicemia 
A)  Malaria 
B)  Babesia infection 
C)  Bartonella infection 
D)  Clostridial septicemia

Question 11

MAHA is often secondary to all of the following conditions except:

Accepted Answer

A)  Infections, especially sepsis 
B)  Obstetric complications 
C)  Renal disease 
D)  Cancer 
A)  Infections, especially sepsis 
B)  Obstetric complications 
C)  Renal disease 
D)  Cancer

Question 12

Renal failure is a prominent feature of:

Accepted Answer

A)  Hemolytic uremic syndrome 
B)  Thrombotic thrombocytopenic purpura 
C)  Plasmodium malariae infection 
D)  March hemoglobinuria 
A)  Hemolytic uremic syndrome 
B)  Thrombotic thrombocytopenic purpura 
C)  Plasmodium malariae infection 
D)  March hemoglobinuria

Question 13

Thick blood films for malaria diagnosis are best used for which purpose?

Accepted Answer

A)  Initial screening 
B)  Determination of the percent of parasitemia 
C)  Speciation 
D)  Identification of stages 
A)  Initial screening 
B)  Determination of the percent of parasitemia 
C)  Speciation 
D)  Identification of stages

Question 14

Which of the following conditions is associated with a deficiency of von Willebrand factor (VWF)-cleaving protease?

Accepted Answer

A)  Hemolytic uremic syndrome 
B)  Thrombotic thrombocytopenic purpura 
C)  March hemoglobinuria 
D)  DIC 
A)  Hemolytic uremic syndrome 
B)  Thrombotic thrombocytopenic purpura 
C)  March hemoglobinuria 
D)  DIC

Exam 24: Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Which of the following is an expected finding in MAHA?

A patient has crescent- or banana-shaped malarial gametocytes. Which of the following is probably true regarding the species of malaria and its clinical course?

Which of the following decreases the ability of malaria species to infect RBCs?

Which of the following techniques most often diagnoses malaria and Babesia infections?

What is the pathogenesis of MAHA?

Why does Plasmodium falciparum infection result in the most serious hemolysis of the various forms of malaria?

All of the following are examples of microangiopathic hemolytic anemias (MAHAs) except:

A mild intravascular hemolytic anemia resulting from forceful repeated effect of the feet on hard surfaces is called:

A patient's red cells show globular fragmentation, budding, and microspherocytes. To what have the red cells probably been exposed?

Which of the following infections is responsible for the most deaths worldwide?

MAHA is often secondary to all of the following conditions except:

Renal failure is a prominent feature of:

Thick blood films for malaria diagnosis are best used for which purpose?

Which of the following conditions is associated with a deficiency of von Willebrand factor (VWF)-cleaving protease?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

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