Question 1

Ringed sideroblasts are a reflection of iron-laden:

Accepted Answer

A)  Mitochondria 
B)  Golgi complex 
C)  Ribosomes 
D)  Rough endoplasmic reticulum 
A)  Mitochondria 
B)  Golgi complex 
C)  Ribosomes 
D)  Rough endoplasmic reticulum

Question 2

Which of the following is decreased in patients with hereditary hemochromatosis?

Accepted Answer

A)  Albumin 
B)  Serum iron 
C)  Transferrin saturation 
D)  Ferritin 
A)  Albumin 
B)  Serum iron 
C)  Transferrin saturation 
D)  Ferritin

Question 3

What would be the likely findings if a bone marrow were performed in a complicated case of iron deficiency anemia?

Accepted Answer

A)  Increased myeloid-to-erythroid (M:
E)  ratio and increased staining with Prussian blue 
B)  Shaggy polychromatophilic normoblasts and no staining with Prussian blue 
C)  Polychromatophilic normoblasts with copious pink cytoplasm and no staining with Prussian blue 
D)  Increased M:E ratio and increased ringed sideroblasts 
A)  Increased myeloid-to-erythroid (M:
E)  ratio and increased staining with Prussian blue 
B)  Shaggy polychromatophilic normoblasts and no staining with Prussian blue 
C)  Polychromatophilic normoblasts with copious pink cytoplasm and no staining with Prussian blue 
D)  Increased M:E ratio and increased ringed sideroblasts

Question 4

Which of the following characterizes stage 1 iron deficiency? Anemia MCV Ferritin

Accepted Answer

A)  Present Decreased Decreased 
B)  Present Normal Normal 
C)  Absent Normal Decreased 
D)  Absent Decreased Normal 
A)  Present Decreased Decreased 
B)  Present Normal Normal 
C)  Absent Normal Decreased 
D)  Absent Decreased Normal

Question 5

Which of the following is true of stage 3 iron deficiency?

Accepted Answer

A)  Serum transferrin receptors are decreased. 
B)  FEP is increased. 
C)  The number of sideroblasts is normal. 
D)  The red cell count is increased, whereas the hematocrit is decreased. 
A)  Serum transferrin receptors are decreased. 
B)  FEP is increased. 
C)  The number of sideroblasts is normal. 
D)  The red cell count is increased, whereas the hematocrit is decreased.

Question 6

What parameter of the routine complete blood count (CBC) is a sensitive indicator of preclinical iron deficiency?

Accepted Answer

A)  Red blood cell distribution width (RDW) 
B)  Hematocrit 
C)  Mean cell hemoglobin (MCH) 
D)  Red blood count 
A)  Red blood cell distribution width (RDW) 
B)  Hematocrit 
C)  Mean cell hemoglobin (MCH) 
D)  Red blood count

Question 7

Chronic blood loss leads to:

Accepted Answer

A)  Iron deficiency anemia 
B)  ACI 
C)  Megaloblastic anemia 
D)  Hemolytic anemia 
A)  Iron deficiency anemia 
B)  ACI 
C)  Megaloblastic anemia 
D)  Hemolytic anemia

Question 8

Most of the clinical findings in the porphyrias are related to:

Accepted Answer

A)  Accumulated porphyrin compounds in tissue 
B)  Anemia 
C)  Reduction in heme production 
D)  Iron being unavailable 
A)  Accumulated porphyrin compounds in tissue 
B)  Anemia 
C)  Reduction in heme production 
D)  Iron being unavailable

Question 9

Why is too much iron dangerous?

Accepted Answer

A)  Transferrin, which carries iron, causes cellular swelling and lysis. 
B)  The oxygen carried by excess iron oxidizes neurologic cells. 
C)  Iron's breakdown products cause excretion of vitamins C and E. 
D)  Free radicals and superoxide formed from ferrous iron plus oxygen damage cell membranes. 
A)  Transferrin, which carries iron, causes cellular swelling and lysis. 
B)  The oxygen carried by excess iron oxidizes neurologic cells. 
C)  Iron's breakdown products cause excretion of vitamins C and E. 
D)  Free radicals and superoxide formed from ferrous iron plus oxygen damage cell membranes.

Question 10

Which group of patients is most likely to develop iron deficiency from increased need?

Accepted Answer

A)  Young men 
B)  Infants and young children 
C)  Postmenopausal women 
D)  Middle-aged men 
A)  Young men 
B)  Infants and young children 
C)  Postmenopausal women 
D)  Middle-aged men

Exam 19: Disorders of Iron and Heme Metabolism

Ringed sideroblasts are a reflection of iron-laden:

Which of the following is decreased in patients with hereditary hemochromatosis?

What would be the likely findings if a bone marrow were performed in a complicated case of iron deficiency anemia?

Which of the following characterizes stage 1 iron deficiency? Anemia MCV Ferritin

Which of the following is true of stage 3 iron deficiency?

What parameter of the routine complete blood count (CBC) is a sensitive indicator of preclinical iron deficiency?

Chronic blood loss leads to:

Most of the clinical findings in the porphyrias are related to:

Why is too much iron dangerous?

Which group of patients is most likely to develop iron deficiency from increased need?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

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