Question 1

Diepoxybutane causes chromosomal breakage in which of the following disorders?

Accepted Answer

A)  Acquired aplastic anemia 
B)  Fanconi anemia 
C)  Diamond-Blackfan anemia 
D)  CDA 
A)  Acquired aplastic anemia 
B)  Fanconi anemia 
C)  Diamond-Blackfan anemia 
D)  CDA B

Question 2

Which of the following is a feature of type II congenital dyserythropoietic anemia type II (CDA II)?

Accepted Answer

A)  Giant, multinucleated red cell precursors 
B)  Microcytic red cells 
C)  Positive sucrose hemolysis test 
D)  Negative acidified serum test (Ham test) 
A)  Giant, multinucleated red cell precursors 
B)  Microcytic red cells 
C)  Positive sucrose hemolysis test 
D)  Negative acidified serum test (Ham test) A

Question 3

Which of the following patients fits the typical patient demographics for aplastic anemia?

Accepted Answer

A)  Infant 
B)  A 65-year-old adult 
C)  A 45-year-old adult 
D)  A 7-year-old child 
A)  Infant 
B)  A 65-year-old adult 
C)  A 45-year-old adult 
D)  A 7-year-old child B

Question 4

Which of the following is an inherited disorder with pancytopenia, malformed kidneys, and mental deficiency?

Accepted Answer

A)  Myelodysplasia 
B)  Fanconi anemia 
C)  Diamond-Blackfan anemia 
D)  Secondary aplastic anemia 
A)  Myelodysplasia 
B)  Fanconi anemia 
C)  Diamond-Blackfan anemia 
D)  Secondary aplastic anemia

Question 5

What is the treatment of choice for a patient older than 40 years old with aplastic anemia?

Accepted Answer

A)  Hematopoietic stem cell transplant 
B)  Antibiotic agents 
C)  Antithymocyte globulin (ATG) 
D)  Erythropoietin 
A)  Hematopoietic stem cell transplant 
B)  Antibiotic agents 
C)  Antithymocyte globulin (ATG) 
D)  Erythropoietin

Question 6

The cause of acquired idiopathic aplastic anemia is:

Accepted Answer

A)  Epstein-Barr virus 
B)  Chemicals such as benzene 
C)  Radiation 
D)  Unknown 
A)  Epstein-Barr virus 
B)  Chemicals such as benzene 
C)  Radiation 
D)  Unknown

Question 7

The red cell morphology associated with aplastic anemia is:

Accepted Answer

A)  Normocytic normochromic with no polychromasia 
B)  Normocytic normochromic with marked polychromasia 
C)  Microcytic hypochromic with marked polychromasia 
D)  Microcytic normochromic with no polychromasia 
A)  Normocytic normochromic with no polychromasia 
B)  Normocytic normochromic with marked polychromasia 
C)  Microcytic hypochromic with marked polychromasia 
D)  Microcytic normochromic with no polychromasia

Question 8

Which of the following would be an unusual bone marrow finding in aplastic anemia?

Accepted Answer

A)  Predominance of lymphocytes, plasma cells, and mast cells 
B)  Hypocellular 
C)  Increased megakaryocytes 
D)  Increased fat 
A)  Predominance of lymphocytes, plasma cells, and mast cells 
B)  Hypocellular 
C)  Increased megakaryocytes 
D)  Increased fat

Question 9

Paroxysmal nocturnal hemoglobinuria has a high degree of association with which one of the following disorders?

Accepted Answer

A)  Aplastic anemia 
B)  Fanconi anemia 
C)  Diamond-Blackfan anemia 
D)  CDA 
A)  Aplastic anemia 
B)  Fanconi anemia 
C)  Diamond-Blackfan anemia 
D)  CDA

Question 10

Which of the following is most useful for considering the diagnosis of bone marrow failure?

Accepted Answer

A)  A hemoglobin concentration of 11 g/dL 
B)  An absolute neutrophil count of less than 0.5*103/dL 
C)  A hypercellular bone marrow 
D)  Abnormal platelet function tests 
A)  A hemoglobin concentration of 11 g/dL 
B)  An absolute neutrophil count of less than 0.5*103/dL 
C)  A hypercellular bone marrow 
D)  Abnormal platelet function tests

Question 11

Pancytopenia is a term that means :

Accepted Answer

A)  Decrease in red cells, white cells, and platelets 
B)  Increase in red and white cells 
C)  Decrease in any two blood cell lines 
D)  Increase in white cells and platelets 
A)  Decrease in red cells, white cells, and platelets 
B)  Increase in red and white cells 
C)  Decrease in any two blood cell lines 
D)  Increase in white cells and platelets

Question 12

Bone marrow failure causes pancytopenia:

Accepted Answer

A)  In the peripheral blood only 
B)  In the bone marrow only 
C)  In both the bone marrow and the peripheral blood 
D)  In the bone marrow, peripheral blood, and spleen 
A)  In the peripheral blood only 
B)  In the bone marrow only 
C)  In both the bone marrow and the peripheral blood 
D)  In the bone marrow, peripheral blood, and spleen

Question 13

What distinguishes PRCAs such as Diamond-Blackfan syndrome from aplastic anemia?

Accepted Answer

A)  Peripheral red blood count 
B)  Number of erythroid stem cells in the bone marrow 
C)  Normal cellularity of myeloid cells 
D)  Red cell indices 
A)  Peripheral red blood count 
B)  Number of erythroid stem cells in the bone marrow 
C)  Normal cellularity of myeloid cells 
D)  Red cell indices

Question 14

What surface antigen on cells identifies them as a hematopoietic stem cell?

Accepted Answer

A)  CD8 
B)  CD34 
C)  CD55 
D)  CD59 
A)  CD8 
B)  CD34 
C)  CD55 
D)  CD59

Question 15

The anemia associated with severe kidney disease is caused primarily by:

Accepted Answer

A)  Damage to stem cells by urea 
B)  Replacement of bone marrow cells with fat 
C)  Deficiency of erythropoietin 
D)  Bleeding into the urine 
A)  Damage to stem cells by urea 
B)  Replacement of bone marrow cells with fat 
C)  Deficiency of erythropoietin 
D)  Bleeding into the urine

Question 16

Normal bone marrow cells being replaced with malignant cells is called:

Accepted Answer

A)  Diamond-Blackfan anemia 
B)  CDA II 
C)  PRCA 
D)  Myelophthisic anemia 
A)  Diamond-Blackfan anemia 
B)  CDA II 
C)  PRCA 
D)  Myelophthisic anemia

Question 17

What is the treatment of choice for long-term survival for patients younger than 40 years old with aplastic anemia?

Accepted Answer

A)  Blood transfusion 
B)  Growth factors 
C)  Antibiotic agents 
D)  Hematopoietic stem cell transplant 
A)  Blood transfusion 
B)  Growth factors 
C)  Antibiotic agents 
D)  Hematopoietic stem cell transplant

Exam 21: Bone Marrow Failure

Diepoxybutane causes chromosomal breakage in which of the following disorders?

Which of the following is a feature of type II congenital dyserythropoietic anemia type II (CDA II)?

Which of the following patients fits the typical patient demographics for aplastic anemia?

Which of the following is an inherited disorder with pancytopenia, malformed kidneys, and mental deficiency?

What is the treatment of choice for a patient older than 40 years old with aplastic anemia?

The cause of acquired idiopathic aplastic anemia is:

The red cell morphology associated with aplastic anemia is:

Which of the following would be an unusual bone marrow finding in aplastic anemia?

Paroxysmal nocturnal hemoglobinuria has a high degree of association with which one of the following disorders?

Which of the following is most useful for considering the diagnosis of bone marrow failure?

Pancytopenia is a term that means :

Bone marrow failure causes pancytopenia:

What distinguishes PRCAs such as Diamond-Blackfan syndrome from aplastic anemia?

What surface antigen on cells identifies them as a hematopoietic stem cell?

The anemia associated with severe kidney disease is caused primarily by:

Normal bone marrow cells being replaced with malignant cells is called:

What is the treatment of choice for long-term survival for patients younger than 40 years old with aplastic anemia?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

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