Question 1

A patient has a hematologic malignancy. Karyotyping is performed for all of the following reasons except:

Accepted Answer

A)  To provide unique cytogenetic profile to confirm the patient's identification 
B)  To provide diagnostic information 
C)  To identify whether the patient will respond to appropriate therapy 
D)  To provide prognostic information 
A)  To provide unique cytogenetic profile to confirm the patient's identification 
B)  To provide diagnostic information 
C)  To identify whether the patient will respond to appropriate therapy 
D)  To provide prognostic information A

Question 2

Nonrandom chromosomal abnormalities are:

Accepted Answer

A)  Congenital chromosome abnormalities that are consistently found in all tissues of an affected individual 
B)  Acquired chromosome abnormalities that are found in the abnormal or malignant tissue of an affected individual 
C)  Acquired chromosome abnormalities that are found in all tissues of an affected individual 
D)  Congenital chromosome abnormalities that are found in only one type of tissue of an affected individual 
A)  Congenital chromosome abnormalities that are consistently found in all tissues of an affected individual 
B)  Acquired chromosome abnormalities that are found in the abnormal or malignant tissue of an affected individual 
C)  Acquired chromosome abnormalities that are found in all tissues of an affected individual 
D)  Congenital chromosome abnormalities that are found in only one type of tissue of an affected individual B

Question 3

Cytogenetics is performed on the bone marrow of a patient, and 20 cells are examined. The patient's karyotype is reported as 47, XX, +7(14), indicating that:

Accepted Answer

A)  This is a female patient with trisomy chromosome 7 found in 14 of the cells examined. 
B)  This is a female patient with monosomy chromosome 7 found in 1 of 4 cells examined. 
C)  This is a male patient with trisomy 7 found in 1 of 4 cells examined. 
D)  This is a male patient with monosomy 7 found in 14 of the cells examined. 
A)  This is a female patient with trisomy chromosome 7 found in 14 of the cells examined. 
B)  This is a female patient with monosomy chromosome 7 found in 1 of 4 cells examined. 
C)  This is a male patient with trisomy 7 found in 1 of 4 cells examined. 
D)  This is a male patient with monosomy 7 found in 14 of the cells examined. A

Question 4

What happens to nuclear chromatin at mitosis?

Accepted Answer

A)  Opens 
B)  Condenses 
C)  Disappears 
D)  Develops nucleoli 
A)  Opens 
B)  Condenses 
C)  Disappears 
D)  Develops nucleoli

Question 5

What chromosome abnormality was the first to be identified and associated with a specific malignancy?

Accepted Answer

A)  Trisomy 8 
B)  Deletion 7 
C)  Philadelphia 
D)  Isocentric chromosome 16 
A)  Trisomy 8 
B)  Deletion 7 
C)  Philadelphia 
D)  Isocentric chromosome 16

Question 6

The period in the cell cycle when deoxyribonucleic acid (DNA) is synthesized is:

Accepted Answer

A)  G1 
B)  S 
C)  G2 
D)  M 
A)  G1 
B)  S 
C)  G2 
D)  M

Question 7

The congenital gain or loss of an entire chromosome in a developing fetus usually results in what type of clinical condition?

Accepted Answer

A)  Sexual ambiguity 
B)  Myeloid leukemia 
C)  Mental retardation 
D)  Usually incompatibility with life 
A)  Sexual ambiguity 
B)  Myeloid leukemia 
C)  Mental retardation 
D)  Usually incompatibility with life

Question 8

What tissue is most often studied for hematologic malignancies?

Accepted Answer

A)  Peripheral blood 
B)  Bone marrow 
C)  Spleen 
D)  Lymph node sections 
A)  Peripheral blood 
B)  Bone marrow 
C)  Spleen 
D)  Lymph node sections

Question 9

A break in two chromosomes with each piece uniting with different chromosomes is called:

Accepted Answer

A)  Deletion 
B)  Duplication 
C)  Insertion 
D)  Translocation 
A)  Deletion 
B)  Duplication 
C)  Insertion 
D)  Translocation

Question 10

All of the following disorders are associated with acquired chromosome abnormalities except:

Accepted Answer

A)  Megaloblastic anemia 
B)  Chronic myelogenous leukemia 
C)  Acute myeloid leukemia 
D)  Acute lymphoblastic leukemia 
A)  Megaloblastic anemia 
B)  Chronic myelogenous leukemia 
C)  Acute myeloid leukemia 
D)  Acute lymphoblastic leukemia

Question 11

How many chromosomes does a human with triploidy have?

Accepted Answer

A)  3 
B)  23 
C)  47 
D)  69 
A)  3 
B)  23 
C)  47 
D)  69

Question 12

What is the best method for detecting chromosomal material that has been structurally altered?

Accepted Answer

A)  Fluorescence in situ hybridization (FISH) 
B)  G banding 
C)  Q banding 
D)  Ag-NOR banding 
A)  Fluorescence in situ hybridization (FISH) 
B)  G banding 
C)  Q banding 
D)  Ag-NOR banding

Question 13

All of the following samples are commonly analyzed for chromosomes except:

Accepted Answer

A)  Bone marrow 
B)  Amniotic fluid 
C)  Peripheral lymphocytes 
D)  Tissue with a low mitotic rate 
A)  Bone marrow 
B)  Amniotic fluid 
C)  Peripheral lymphocytes 
D)  Tissue with a low mitotic rate

Question 14

Which of the following is true regarding the number of chromosomes of different species?

Accepted Answer

A)  All mammals have the same number. 
B)  Numbers vary greatly among mammals unrelated to characteristics. 
C)  Primates have more than lower mammals. 
D)  Primates have fewer than lower mammals. 
A)  All mammals have the same number. 
B)  Numbers vary greatly among mammals unrelated to characteristics. 
C)  Primates have more than lower mammals. 
D)  Primates have fewer than lower mammals.

Question 15

Where is a gene designated 9p23 located?

Accepted Answer

A)  Short arm of chromosome 23, region 9 
B)  Long arm of chromosome 3, region 2, band 9 
C)  Short arm of chromosome 9, region 2, band 3 
D)  On the translocated part of chromosome 9 on chromosome 23 
A)  Short arm of chromosome 23, region 9 
B)  Long arm of chromosome 3, region 2, band 9 
C)  Short arm of chromosome 9, region 2, band 3 
D)  On the translocated part of chromosome 9 on chromosome 23

Question 16

Cell division to produce daughter cells identical to the parent cell is an example of:

Accepted Answer

A)  Nondisjunction 
B)  Meiosis 
C)  Mitosis 
D)  Gamete production 
A)  Nondisjunction 
B)  Meiosis 
C)  Mitosis 
D)  Gamete production

Question 17

A chromosome number that is not a multiple of the haploid number is:

Accepted Answer

A)  Aneuploidy 
B)  Mosaic 
C)  Polyploidy 
D)  Incompatible with life 
A)  Aneuploidy 
B)  Mosaic 
C)  Polyploidy 
D)  Incompatible with life

Exam 31: Cytogenetics

A patient has a hematologic malignancy. Karyotyping is performed for all of the following reasons except:

Nonrandom chromosomal abnormalities are:

Cytogenetics is performed on the bone marrow of a patient, and 20 cells are examined. The patient's karyotype is reported as 47, XX, +7(14), indicating that:

What happens to nuclear chromatin at mitosis?

What chromosome abnormality was the first to be identified and associated with a specific malignancy?

The period in the cell cycle when deoxyribonucleic acid (DNA) is synthesized is:

The congenital gain or loss of an entire chromosome in a developing fetus usually results in what type of clinical condition?

What tissue is most often studied for hematologic malignancies?

A break in two chromosomes with each piece uniting with different chromosomes is called:

All of the following disorders are associated with acquired chromosome abnormalities except:

How many chromosomes does a human with triploidy have?

What is the best method for detecting chromosomal material that has been structurally altered?

All of the following samples are commonly analyzed for chromosomes except:

Which of the following is true regarding the number of chromosomes of different species?

Where is a gene designated 9p23 located?

Cell division to produce daughter cells identical to the parent cell is an example of:

A chromosome number that is not a multiple of the haploid number is:

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

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