Question 1

Why are patients with plasma cell myeloma susceptible to infection?

Accepted Answer

A)  Decreased lymphocytes 
B)  Neutropenia 
C)  Suppressed normal immunoglobulin levels 
D)  Both b and c 
A)  Decreased lymphocytes 
B)  Neutropenia 
C)  Suppressed normal immunoglobulin levels 
D)  Both b and c D

Question 2

What is the clinical significance of an enlarged lymph node?

Accepted Answer

A)  Usually benign related to an infection 
B)  Usually indicates lymphoma 
C)  Can be benign or malignant depending on the microscopic evaluation 
D)  Diagnostic for an autoimmune disorder 
A)  Usually benign related to an infection 
B)  Usually indicates lymphoma 
C)  Can be benign or malignant depending on the microscopic evaluation 
D)  Diagnostic for an autoimmune disorder C

Question 3

Which of the following is true regarding the clinical course of chronic lymphocytic leukemia?

Accepted Answer

A)  Aggressive disorder that presents with severe bleeding and anemia 
B)  Benign disorder that rarely requires treatment 
C)  Mild symptoms but usually fatal within 6 months 
D)  Incurable but with a median survival of approximately 10 years 
A)  Aggressive disorder that presents with severe bleeding and anemia 
B)  Benign disorder that rarely requires treatment 
C)  Mild symptoms but usually fatal within 6 months 
D)  Incurable but with a median survival of approximately 10 years D

Question 4

Mature T cells with cerebriform, clefted nuclei found in the skin and peripheral blood describe:

Accepted Answer

A)  Hairy cells 
B)  Prolymphocytes 
C)  Lymphoblasts 
D)  Sézary cells 
A)  Hairy cells 
B)  Prolymphocytes 
C)  Lymphoblasts 
D)  Sézary cells

Question 5

Which of the following are mature pan-B cell markers?

Accepted Answer

A)  CD4 and CD8 
B)  CD33 and CD45 
C)  CD19 and CD20 
D)  CD33 and CD59 
A)  CD4 and CD8 
B)  CD33 and CD45 
C)  CD19 and CD20 
D)  CD33 and CD59

Question 6

Where are malignant plasma cells found in plasma cell myeloma?

Accepted Answer

A)  Bone marrow and sometimes in the peripheral blood 
B)  Lymph nodes and liver 
C)  Spleen and liver 
D)  Bone marrow and lymph nodes 
A)  Bone marrow and sometimes in the peripheral blood 
B)  Lymph nodes and liver 
C)  Spleen and liver 
D)  Bone marrow and lymph nodes

Question 7

Which of the following is true of plasma cells?

Accepted Answer

A)  Express pan-B cell markers 
B)  Express surface immunoglobulin 
C)  Express cytoplasmic immunoglobulin 
D)  Express pan-T cell markers 
A)  Express pan-B cell markers 
B)  Express surface immunoglobulin 
C)  Express cytoplasmic immunoglobulin 
D)  Express pan-T cell markers

Question 8

Why is Burkitt lymphoma such an aggressive malignancy?

Accepted Answer

A)  Cells readily metastasize to bone marrow. 
B)  Cells have a high proliferative rate. 
C)  Cells fail to mature to functional immunophenotype. 
D)  Cells destroy red cells. 
A)  Cells readily metastasize to bone marrow. 
B)  Cells have a high proliferative rate. 
C)  Cells fail to mature to functional immunophenotype. 
D)  Cells destroy red cells.

Question 9

Normal lymph nodes contain all of the following cell types except:

Accepted Answer

A)  Myelocytes 
B)  Plasma cells 
C)  Lymphocytes 
D)  Macrophages 
A)  Myelocytes 
B)  Plasma cells 
C)  Lymphocytes 
D)  Macrophages

Question 10

What is the diagnostic cell, found in involved lymph nodes, for Hodgkin lymphoma?

Accepted Answer

A)  Small B lymphocyte 
B)  Plasma cell 
C)  Small T lymphocyte 
D)  Reed-Sternberg cell 
A)  Small B lymphocyte 
B)  Plasma cell 
C)  Small T lymphocyte 
D)  Reed-Sternberg cell

Question 11

Which of the following are mature pan-T cell markers?

Accepted Answer

A)  CD3 and CD5 
B)  Surface immunoglobulin 
C)  CD4 and CD45 
D)  CD4 and CD8 
A)  CD3 and CD5 
B)  Surface immunoglobulin 
C)  CD4 and CD45 
D)  CD4 and CD8

Question 12

What is the preferred specimen to evaluate cellular morphology in the lymphoproliferative disorders?

Accepted Answer

A)  Peripheral blood 
B)  Bone marrow 
C)  Node frozen sections 
D)  Touch imprints of nodes 
A)  Peripheral blood 
B)  Bone marrow 
C)  Node frozen sections 
D)  Touch imprints of nodes

Question 13

The strongest risk factor for development of a lymphoproliferative disorders is:

Accepted Answer

A)  Age 15 to 34 years 
B)  Altered immune function 
C)  Female sex 
D)  Cytomegalovirus infection in childhood 
A)  Age 15 to 34 years 
B)  Altered immune function 
C)  Female sex 
D)  Cytomegalovirus infection in childhood

Question 14

Which of the following is true regarding classic Hodgkin lymphoma?

Accepted Answer

A)  It is seen in young adults and includes enlarged mediastinal lymph nodes. 
B)  It is seen in young children and includes with splenomegaly. 
C)  It is seen in young adults and is rapidly fatal in most cases. 
D)  It is seen in older adults and spreads through the body before any symptoms develop. 
A)  It is seen in young adults and includes enlarged mediastinal lymph nodes. 
B)  It is seen in young children and includes with splenomegaly. 
C)  It is seen in young adults and is rapidly fatal in most cases. 
D)  It is seen in older adults and spreads through the body before any symptoms develop.

Question 15

Serum protein electrophoresis on an elderly patient reveals a monoclonal protein spike. Increased plasma cells are present in the bone marrow. They are CD19 and CD20 negative but demonstrate high-density CD38 and monoclonal cytoplasmic immunoglobulin. What is the most likely diagnosis?

Accepted Answer

A)  Plasma cell myeloma 
B)  Hodgkin lymphoma 
C)  Burkitt lymphoma 
D)  Chronic lymphocytic leukemia 
A)  Plasma cell myeloma 
B)  Hodgkin lymphoma 
C)  Burkitt lymphoma 
D)  Chronic lymphocytic leukemia

Question 16

Neoplastic lymphocytes with noncleaved clumped nuclei and very basophilic cytoplasm with prominent vacuoles describes:

Accepted Answer

A)  Reed-Sternberg cells 
B)  Mantle cell lymphoma cells 
C)  Small-cell lymphocytic lymphoma cells 
D)  Burkitt lymphoma cells 
A)  Reed-Sternberg cells 
B)  Mantle cell lymphoma cells 
C)  Small-cell lymphocytic lymphoma cells 
D)  Burkitt lymphoma cells

Question 17

All of the following are functions of normal lymph nodes except:

Accepted Answer

A)  Lymphopoiesis 
B)  Granulopoiesis 
C)  Processing antigens 
D)  Antigen recognition 
A)  Lymphopoiesis 
B)  Granulopoiesis 
C)  Processing antigens 
D)  Antigen recognition

Question 18

Malignant proliferation of plasma cells with osteolytic bone lesions and the presence of monoclonal immunoglobulin in the serum describe:

Accepted Answer

A)  Waldenström macroglobulinemia 
B)  Marginal zone B-cell lymphoma 
C)  Follicle center lymphoma 
D)  Plasma cell myeloma 
A)  Waldenström macroglobulinemia 
B)  Marginal zone B-cell lymphoma 
C)  Follicle center lymphoma 
D)  Plasma cell myeloma

Question 19

A middle-aged man has a white blood cell (WBC) count of 80 * 109/L with 90% lymphocytes and many smudge cells. Which of the following is most likely?

Accepted Answer

A)  Chronic lymphocytic leukemia 
B)  Hairy cell leukemia 
C)  T-cell lymphoma 
D)  Sézary syndrome 
A)  Chronic lymphocytic leukemia 
B)  Hairy cell leukemia 
C)  T-cell lymphoma 
D)  Sézary syndrome

Question 20

What lymphoproliferative disorder has a very favorable response to highly aggressive chemotherapy with no radiotherapy?

Accepted Answer

A)  Chronic lymphocytic leukemia 
B)  Mycosis fungoides 
C)  Hodgkin lymphoma 
D)  Burkitt lymphoma 
A)  Chronic lymphocytic leukemia 
B)  Mycosis fungoides 
C)  Hodgkin lymphoma 
D)  Burkitt lymphoma

Exam 37: Mature Lymphoid Neoplasms

Why are patients with plasma cell myeloma susceptible to infection?

What is the clinical significance of an enlarged lymph node?

Which of the following is true regarding the clinical course of chronic lymphocytic leukemia?

Mature T cells with cerebriform, clefted nuclei found in the skin and peripheral blood describe:

Which of the following are mature pan-B cell markers?

Where are malignant plasma cells found in plasma cell myeloma?

Which of the following is true of plasma cells?

Why is Burkitt lymphoma such an aggressive malignancy?

Normal lymph nodes contain all of the following cell types except:

What is the diagnostic cell, found in involved lymph nodes, for Hodgkin lymphoma?

Which of the following are mature pan-T cell markers?

What is the preferred specimen to evaluate cellular morphology in the lymphoproliferative disorders?

The strongest risk factor for development of a lymphoproliferative disorders is:

Which of the following is true regarding classic Hodgkin lymphoma?

Serum protein electrophoresis on an elderly patient reveals a monoclonal protein spike. Increased plasma cells are present in the bone marrow. They are CD19 and CD20 negative but demonstrate high-density CD38 and monoclonal cytoplasmic immunoglobulin. What is the most likely diagnosis?

Neoplastic lymphocytes with noncleaved clumped nuclei and very basophilic cytoplasm with prominent vacuoles describes:

All of the following are functions of normal lymph nodes except:

Malignant proliferation of plasma cells with osteolytic bone lesions and the presence of monoclonal immunoglobulin in the serum describe:

A middle-aged man has a white blood cell (WBC) count of 80 * 109/L with 90% lymphocytes and many smudge cells. Which of the following is most likely?

What lymphoproliferative disorder has a very favorable response to highly aggressive chemotherapy with no radiotherapy?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Energy Metabolism and Membrane Physiology of the Erythrocyte

Hemoglobin Metabolism

Iron Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Routine and Point-Of-Care Testing in Hematology: Manual and Semiautomated Methods

Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

Bone Marrow Examination

Body Fluids in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron and Heme Metabolism

Anemias Caused by Defects of Dna Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocytedestructionnonimmune Causes

Extrinsic Defects Leading to Increased Erythrocytedestructionimmune Causes

Hemoglobinopathies Structural Defects in Hemoglobin

Thalassemias

Nonmalignant Leukocyte Disorders

Introduction to Leukocyte Neoplasms

Cytochemistry

Cytogenetics

Molecular Diagnostics in the Clinical Laboratory

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Pediatric and Geriatric Hematology

Automated Cell-Counting Instrumentation

Normal Hemostasis and Coagulation

Hemorrhagic Coagulation Disorders

Thrombosis Risk Testing

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Monitoring Antithrombotic Therapies

Coagulation Instrumentation

Filters

A middle-aged man has a white blood cell (WBC) count of 80 * 10⁹/L with 90% lymphocytes and many smudge cells. Which of the following is most likely?