Exam 16: Diseases of the Liver Gallbladder and Exocrine Pancreas

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Identify the enzyme that hydrolyzes interior peptide bonds to form polypeptides.

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Describe the major functions of the pancreas.

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The pancreas has two major functions: exocrine function, which produces enzymes and bicarbonate necessary for digestion, and endocrine function, which produces hormones to regulate the use of body fuels.

The most common causes of cirrhosis are chronic HCV and alcoholism, and 95% of heavy drinkers develop the disease.

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When ascites is present, which nutrition modification is typically necessary?

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JB is a 53-year-old male who has recently divorced. He has experienced periods of depression and decreased appetite. His family reports a history of heavy drinking habits and a 15 kg weight loss. He was previously diagnosed with cirrhosis and portal hypertension. Paracentesis and TIPS procedures were performed. JB's condition seems to have worsened; he complains of stomach pains, nausea, and vomiting at times. His abdomen is sore to touch and feels swollen. JB has developed ascites and pedal edema. His urinary output has decreased, and he continues to lose weight. JB also complains of pain when swallowing food. Because of JB's persistent symptoms, he's been admitted to a hospital. A referral to the SLP for an MBS was also ordered and resulted in dysphagia for which pureed diet was recommended. On day 2, JB still complains of nausea and no per os intake has been reported. The MD prescribed a dietary consultation. An RD is required to assess the patient and recommend alternate means of nutrition support, currently NPO. Ht:5′11′′ \mathrm{Ht}: 5^{\prime} 11^{\prime \prime} \quad Wt: 145# 145 \quad \# UBW: 163# 163 \# Dx: End-stage liver cirrhosis, dysphagia PMH: alcoholic cirrhosis, portal hypertension Labs: Na: 134 Cl: 101 BUN: 4 Alb: 2.3 TG: 305 Transferrin: 101 NH4: 53 Glu: 139 AST: 45 ALT 48 Alk Phos: 40 Bilirubin: 2.1 K: 5.2 CO2: 25 Cr: 1.8 H/H: 11/35 Diet: NPO Meds: Neomycin, Aldactone, Lasix, Reglan -How much protein consumption will the registered dietitian recommend to JB?

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At which level of serum bilirubin does the skin begin to appear jaundiced?

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Alcohol causes increased urinary excretion of which nutrient?

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Small crystals of cholesterol on the surface of the inflamed mucosa of the gallbladder act as _______________ (points of origin) for further precipitation of cholesterol, and the crystals grow larger and larger.

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Ethanol and acetaldehyde have a hepatotoxic effect that interferes with metabolism and activation of vitamins by liver cells.

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_______________ is defined as the replacement of functional hepatocytes by fibrotic cells.

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Describe the differences between acute and chronic pancreatitis, including causes, manifestations, and nutrition intervention.

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The pancreas is the only organ of the body that has both _______________ and _______________ functions.

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Which type of food would the dietitian most likely recommend to a patient with nonalcoholic fatty liver disease (NAFLD)?

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JB is a 53-year-old male who has recently divorced. He has experienced periods of depression and decreased appetite. His family reports a history of heavy drinking habits and a 15 kg weight loss. He was previously diagnosed with cirrhosis and portal hypertension. Paracentesis and TIPS procedures were performed. JB's condition seems to have worsened; he complains of stomach pains, nausea, and vomiting at times. His abdomen is sore to touch and feels swollen. JB has developed ascites and pedal edema. His urinary output has decreased, and he continues to lose weight. JB also complains of pain when swallowing food. Because of JB's persistent symptoms, he's been admitted to a hospital. A referral to the SLP for an MBS was also ordered and resulted in dysphagia for which pureed diet was recommended. On day 2, JB still complains of nausea and no per os intake has been reported. The MD prescribed a dietary consultation. An RD is required to assess the patient and recommend alternate means of nutrition support, currently NPO. Ht:5′11′′ \mathrm{Ht}: 5^{\prime} 11^{\prime \prime} \quad Wt: 145# 145 \quad \# UBW: 163# 163 \# Dx: End-stage liver cirrhosis, dysphagia PMH: alcoholic cirrhosis, portal hypertension Labs: Na: 134 Cl: 101 BUN: 4 Alb: 2.3 TG: 305 Transferrin: 101 NH4: 53 Glu: 139 AST: 45 ALT 48 Alk Phos: 40 Bilirubin: 2.1 K: 5.2 CO2: 25 Cr: 1.8 H/H: 11/35 Diet: NPO Meds: Neomycin, Aldactone, Lasix, Reglan -Because of JB's history of alcohol abuse, he is most likely at risk of which nutrient deficiency?

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The cause of fatty liver after alcohol ingestion is:

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The hepatic duct descends to the right for a few inches and is then joined by the cystic duct from the gallbladder to form the _______________.

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Common manifestations of all types of hepatitis include jaundice, fatigue, vomiting, and:

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The basic functional unit of the liver is the _______________, which is a cylindrical structure several millimeters in length and 0.8-2 mm in diameter.

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Which hormone is secreted by the delta cells of the islets of Langerhans?

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Which organ stores bile that is produced in the liver?

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