Question 1

The Wright blood group antigens belong to which blood group system?

Accepted Answer

A)  Wr 
B)  DI 
C)  DO 
D)  SC 
A)  Wr 
B)  DI 
C)  DO 
D)  SC

Question 2

End-stage renal disease may be present in persons with alloanti-MER2 because:

Accepted Answer

A)  MER2- persons who have MER2 on cells other than RBCs will make alloanti-MER2. 
B)  MER2 is essential for assembly of basement membranes in the kidneys. 
C)  persons who have made anti-MER2 do not exhibit CD151 mutations. 
D)  persons who have made alloanti-MER2 are MER2+. 
A)  MER2- persons who have MER2 on cells other than RBCs will make alloanti-MER2. 
B)  MER2 is essential for assembly of basement membranes in the kidneys. 
C)  persons who have made anti-MER2 do not exhibit CD151 mutations. 
D)  persons who have made alloanti-MER2 are MER2+.

Question 3

An antibody that reacts in the IAT phase of the antiglobulin test and whose antigen expression is depressed by the In (Lu) gene is:

Accepted Answer

A)  anti-Xga. 
B)  anti-Ytb . 
C)  anti-Inb. 
D)  anti-Sc1. 
A)  anti-Xga. 
B)  anti-Ytb . 
C)  anti-Inb. 
D)  anti-Sc1.

Question 4

Anti-JMH is found mostly in patients who:

Accepted Answer

A)  lack the JMH protein from birth. 
B)  form the antibody early in life 
C)  lost the JMH antigen later in life. 
D)  show autoimmune RBC destruction. 
A)  lack the JMH protein from birth. 
B)  form the antibody early in life 
C)  lost the JMH antigen later in life. 
D)  show autoimmune RBC destruction.

Question 5

The Hu antigen is present in the highest prevalence in which people group?

Accepted Answer

A)  African Americas 
B)  Native Americans 
C)  West Africans 
D)  Southeast Asians 
A)  African Americas 
B)  Native Americans 
C)  West Africans 
D)  Southeast Asians

Question 6

What blood group antigens are involved in the regulation of complement because they are located on decoy accelerating factor?

Accepted Answer

A)  CO 
B)  DO 
C)  CROM 
D)  IN 
A)  CO 
B)  DO 
C)  CROM 
D)  IN

Question 7

Which of the following is a characteristic of the Rh-associated glycoprotein (RhAG) ?

Accepted Answer

A)  RhAG does not have Rh blood group antigens. 
B)  RhAG is present in a complex with the Rh proteins. 
C)  RhAG is essential for Rh antigen expression. 
D)  These are all characteristics of RhAG. 
A)  RhAG does not have Rh blood group antigens. 
B)  RhAG is present in a complex with the Rh proteins. 
C)  RhAG is essential for Rh antigen expression. 
D)  These are all characteristics of RhAG.

Question 8

Which antigen is useful as a genetic marker for Mongolian derivation and anthropologic studies?

Accepted Answer

A)  Yta 
B)  Dia 
C)  Sda 
D)  Xga 
A)  Yta 
B)  Dia 
C)  Sda 
D)  Xga

Question 9

The rarely encountered Scianna antibodies react in which phase of the antibody screen?

Accepted Answer

A)  Immediate spin 
B)  37°C 
C)  AHG 
D)  All of the above 
A)  Immediate spin 
B)  37°C 
C)  AHG 
D)  All of the above

Question 10

The Sc1 antigen occurs in approximately what percentage of the random population?

Accepted Answer

A)  100% 
B)  50% 
C)  10% 
D)  35% 
A)  100% 
B)  50% 
C)  10% 
D)  35%

Question 11

All of the following are inconsistent with Xga antibody characteristics except:

Accepted Answer

A)  reactive at the IAT phase. 
B)  IgM immunoglobulins. 
C)  resistant to enzymes. 
D)  known to cause HTRs. 
A)  reactive at the IAT phase. 
B)  IgM immunoglobulins. 
C)  resistant to enzymes. 
D)  known to cause HTRs.

Question 12

High prevalence Gerbich-negative phenotypes include all of these EXCEPT

Accepted Answer

A)  GEAT 
B)  GEIS 
C)  GEPL 
D)  GETI 
A)  GEAT 
B)  GEIS 
C)  GEPL 
D)  GETI

Question 13

Anti-Vel is able to cause:

Accepted Answer

A)  severe immediate hemolytic transfusion reactions. 
B)  hemolytic disease of the fetus and newborn. 
C)  both of these 
D)  neither of these 
A)  severe immediate hemolytic transfusion reactions. 
B)  hemolytic disease of the fetus and newborn. 
C)  both of these 
D)  neither of these

Question 14

Disease associations have linked which Colton phenotype with monosomy-7?

Accepted Answer

A)  Co(a+b-) 
B)  Co(a+b+) 
C)  Co(a-b+) 
D)  Co(a-b-) 
A)  Co(a+b-) 
B)  Co(a+b+) 
C)  Co(a-b+) 
D)  Co(a-b-)

Question 15

How does complement aid in the identification of alloantibodies masked by anti-Cha?

Accepted Answer

A)  C4d in plasma will absorb anti-Cha. 
B)  C3b in serum will absorb anti-Cha. 
C)  C3d in plasma will absorb anti-Cha. 
D)  C4a in plasma will absorb anti-Cha. 
A)  C4d in plasma will absorb anti-Cha. 
B)  C3b in serum will absorb anti-Cha. 
C)  C3d in plasma will absorb anti-Cha. 
D)  C4a in plasma will absorb anti-Cha.

Question 16

Placental tissue will absorb antibodies from which blood group?

Accepted Answer

A)  Augustine 
B)  Cromer 
C)  Forssman 
D)  Gerbich 
A)  Augustine 
B)  Cromer 
C)  Forssman 
D)  Gerbich

Question 17

Which antigen is resistant to DTT?

Accepted Answer

A)  Chido 
B)  Dombrock 
C)  Knops 
D)  All of these 
A)  Chido 
B)  Dombrock 
C)  Knops 
D)  All of these

Question 18

Cord blood can be used to differentiate anti-LW and anti-D antibodies because:

Accepted Answer

A)  anti-LW reacts equally well with cord RBCs regardless of their D type. 
B)  anti-LW reacts only with D+ cord blood and not D- cord blood. 
C)  anti-LW reacts only with D- cord blood and not with D+ cord blood. 
D)  anti-LW reacts only with adult cells and not with cord blood. 
A)  anti-LW reacts equally well with cord RBCs regardless of their D type. 
B)  anti-LW reacts only with D+ cord blood and not D- cord blood. 
C)  anti-LW reacts only with D- cord blood and not with D+ cord blood. 
D)  anti-LW reacts only with adult cells and not with cord blood.

Question 19

LW has a phenotypic relationship with the antigen.

Accepted Answer

A)  D 
B)  P1 
C)  M 
D)  Wra 
A)  D 
B)  P1 
C)  M 
D)  Wra

Question 20

The presence of normal GPA (MNS system) is required for the expression of:

Accepted Answer

A)  Coa 
B)  Dob 
C)  Wrb 
D)  Yta 
A)  Coa 
B)  Dob 
C)  Wrb 
D)  Yta

Exam 9: Uncommon Blood Groups

The Wright blood group antigens belong to which blood group system?

End-stage renal disease may be present in persons with alloanti-MER2 because:

An antibody that reacts in the IAT phase of the antiglobulin test and whose antigen expression is depressed by the In (Lu) gene is:

Anti-JMH is found mostly in patients who:

The Hu antigen is present in the highest prevalence in which people group?

What blood group antigens are involved in the regulation of complement because they are located on decoy accelerating factor?

Which of the following is a characteristic of the Rh-associated glycoprotein (RhAG) ?

Which antigen is useful as a genetic marker for Mongolian derivation and anthropologic studies?

The rarely encountered Scianna antibodies react in which phase of the antibody screen?

The Sc1 antigen occurs in approximately what percentage of the random population?

All of the following are inconsistent with Xga antibody characteristics except:

High prevalence Gerbich-negative phenotypes include all of these EXCEPT

Anti-Vel is able to cause:

Disease associations have linked which Colton phenotype with monosomy-7?

How does complement aid in the identification of alloantibodies masked by anti-Cha?

Placental tissue will absorb antibodies from which blood group?

Which antigen is resistant to DTT?

Cord blood can be used to differentiate anti-LW and anti-D antibodies because:

LW has a phenotypic relationship with the antigen.

The presence of normal GPA (MNS system) is required for the expression of:

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters

All of the following are inconsistent with Xg^a antibody characteristics except:

How does complement aid in the identification of alloantibodies masked by anti-Ch^a?