Question 1

All of the following are immediate nonhemolytic transfusion reactions, except:

Accepted Answer

A)  being febrile. 
B)  PTP. 
C)  anaphylaxis. 
D)  an allergic response. 
A)  being febrile. 
B)  PTP. 
C)  anaphylaxis. 
D)  an allergic response.

Question 2

What would be the result of group B blood given to a group O patient?

Accepted Answer

A)  Nonimmune transfusion reaction 
B)  Immediate hemolytic transfusion reaction 
C)  Delayed hemolytic transfusion reaction 
D)  No reaction 
A)  Nonimmune transfusion reaction 
B)  Immediate hemolytic transfusion reaction 
C)  Delayed hemolytic transfusion reaction 
D)  No reaction

Question 3

In a DHTR, patient antibody attaches to the specific foreign donor red blood cell antigen, causing sensitization of red blood cells, which are removed by the:

Accepted Answer

A)  complement system. 
B)  kidneys. 
C)  reticuloendothelial system (RES). 
D)  MHC complex. 
A)  complement system. 
B)  kidneys. 
C)  reticuloendothelial system (RES). 
D)  MHC complex.

Question 4

All of the following signs are consistent with circulatory overload except:

Accepted Answer

A)  orthopnea. 
B)  fever. 
C)  dyspnea. 
D)  tachycardia. 
A)  orthopnea. 
B)  fever. 
C)  dyspnea. 
D)  tachycardia.

Question 5

What measure can be taken to prevent transfusion-associated hypothermia?

Accepted Answer

A)  Prudent use of platelet concentrates 
B)  Close monitoring of patient vital signs 
C)  Transfusion of product using a blood warmer 
D)  Premedication with calcium gluconate 
A)  Prudent use of platelet concentrates 
B)  Close monitoring of patient vital signs 
C)  Transfusion of product using a blood warmer 
D)  Premedication with calcium gluconate

Question 6

Which of the following describes the etiology of GVHD?

Accepted Answer

A)  Anti-PLA1 attaches to platelet surface, permitting extravascular destruction by RES 
B)  B lymphocytes from donor blood react with major and minor histocompatibility antigens in the patient 
C)  T lymphocytes from donor blood react with major and minor histocompatibility antigens in the patient 
D)  Alloantibody in patient serum reacts with donor red blood cells 
A)  Anti-PLA1 attaches to platelet surface, permitting extravascular destruction by RES 
B)  B lymphocytes from donor blood react with major and minor histocompatibility antigens in the patient 
C)  T lymphocytes from donor blood react with major and minor histocompatibility antigens in the patient 
D)  Alloantibody in patient serum reacts with donor red blood cells

Question 7

A transfusion reaction investigation should include all of the following except:

Accepted Answer

A)  diagnosis. 
B)  current medication. 
C)  neocyte transfusion. 
D)  washed RBCs. 
A)  diagnosis. 
B)  current medication. 
C)  neocyte transfusion. 
D)  washed RBCs.

Question 8

The principle clinical signs of extravascular hemolysis include:

Accepted Answer

A)  bilirubinemia mostly of the direct type. 
B)  hemoglobinuria. 
C)  positive DAT. 
D)  bilirubinemia and positive DAT. 
A)  bilirubinemia mostly of the direct type. 
B)  hemoglobinuria. 
C)  positive DAT. 
D)  bilirubinemia and positive DAT.

Question 9

Alloimmunization is categorized as what type of transfusion reaction?

Accepted Answer

A)  Immediate nonhemolytic 
B)  Immediate hemolytic 
C)  Delayed nonhemolytic 
D)  Delayed hemolytic 
A)  Immediate nonhemolytic 
B)  Immediate hemolytic 
C)  Delayed nonhemolytic 
D)  Delayed hemolytic

Question 10

An O-positive patient transfused with A-positive red blood cells would experience which of the following clinical manifestations?

Accepted Answer

A)  Acute hemolysis 
B)  Delayed hemolytic transfusion reaction 
C)  Anaphylaxis 
D)  External hemolysis 
A)  Acute hemolysis 
B)  Delayed hemolytic transfusion reaction 
C)  Anaphylaxis 
D)  External hemolysis

Question 11

Which of the following is not a finding associated with intravascular hemolytic reaction?

Accepted Answer

A)  Methemalbumin decreases 
B)  Haptoglobin decreases 
C)  Increased free hemoglobin in the plasma 
D)  Increased free hemoglobin in the urine 
A)  Methemalbumin decreases 
B)  Haptoglobin decreases 
C)  Increased free hemoglobin in the plasma 
D)  Increased free hemoglobin in the urine

Question 12

Hypothermia as a result of cold fluid replacement can result in all of the following except:

Accepted Answer

A)  hemolysis. 
B)  abnormal electrocardiogram. 
C)  coagulopathy. 
D)  citrate toxicity. 
A)  hemolysis. 
B)  abnormal electrocardiogram. 
C)  coagulopathy. 
D)  citrate toxicity.

Question 13

Which of the following organisms have been implicated in bacterial contamination reactions?

Accepted Answer

A)  Corynebacterium flavescens 
B)  Yersinia enterocolitica 
C)  Enterobacter aerogenes 
D)  Clostridium perfringens 
A)  Corynebacterium flavescens 
B)  Yersinia enterocolitica 
C)  Enterobacter aerogenes 
D)  Clostridium perfringens

Question 14

What test is indicated for the detection of HLA antibodies?

Accepted Answer

A)  Direct Coombs' 
B)  Antibody screen 
C)  Lymphocyte panels 
D)  Cold antibody panel 
A)  Direct Coombs' 
B)  Antibody screen 
C)  Lymphocyte panels 
D)  Cold antibody panel

Question 15

What is the primary mediator of an allergic response?

Accepted Answer

A)  Melatonin 
B)  Lysozyme 
C)  Histamine 
D)  Pyrimidine 
A)  Melatonin 
B)  Lysozyme 
C)  Histamine 
D)  Pyrimidine

Question 16

What type of hemolysis accompanies an anaphylactic reaction?

Accepted Answer

A)  Intravascular 
B)  Extravascular 
C)  Acute 
D)  None of the above 
A)  Intravascular 
B)  Extravascular 
C)  Acute 
D)  None of the above

Question 17

Which of the following is consistent with bacterial contamination reactions?

Accepted Answer

A)  The organism is a fastidious anaerobe. 
B)  The organism thrives in warm temperatures. 
C)  The organism thrives in cold temperatures. 
D)  The organism exhibits motility. 
A)  The organism is a fastidious anaerobe. 
B)  The organism thrives in warm temperatures. 
C)  The organism thrives in cold temperatures. 
D)  The organism exhibits motility.

Question 18

Changes that occur to RBCs upon storage include an increase in

Accepted Answer

A)  ATP. 
B)  calcium. 
C)  glucose. 
D)  all of these. 
A)  ATP. 
B)  calcium. 
C)  glucose. 
D)  all of these.

Question 19

What is meant by the term iatrogenic?

Accepted Answer

A)  Generic treatment 
B)  Underlying disease 
C)  Physician-caused 
D)  Hospital-contracted 
A)  Generic treatment 
B)  Underlying disease 
C)  Physician-caused 
D)  Hospital-contracted

Question 20

A patient undergoing transfusion of packed red blood cells became hypotensive and cyanotic 30 minutes into the transfusion. The nurse also noted a 0.8°C increase in temperature. The transfusion was stopped and post-blood specimens were sent down to the laboratory for a transfusion reaction investigation. The donor serum was tested against screening cells (3-vials) and was reactive at AHG in all vials. A panel was performed, and anti-Bga was identified. What special blood component should this patient now receive?

Accepted Answer

A)  Leukopoor 
B)  Washed 
C)  Deglycerolized 
D)  None of the above 
A)  Leukopoor 
B)  Washed 
C)  Deglycerolized 
D)  None of the above

Exam 17: Adverse Effects of Blood Transfusion

All of the following are immediate nonhemolytic transfusion reactions, except:

What would be the result of group B blood given to a group O patient?

In a DHTR, patient antibody attaches to the specific foreign donor red blood cell antigen, causing sensitization of red blood cells, which are removed by the:

All of the following signs are consistent with circulatory overload except:

What measure can be taken to prevent transfusion-associated hypothermia?

Which of the following describes the etiology of GVHD?

A transfusion reaction investigation should include all of the following except:

The principle clinical signs of extravascular hemolysis include:

Alloimmunization is categorized as what type of transfusion reaction?

An O-positive patient transfused with A-positive red blood cells would experience which of the following clinical manifestations?

Which of the following is not a finding associated with intravascular hemolytic reaction?

Hypothermia as a result of cold fluid replacement can result in all of the following except:

Which of the following organisms have been implicated in bacterial contamination reactions?

What test is indicated for the detection of HLA antibodies?

What is the primary mediator of an allergic response?

What type of hemolysis accompanies an anaphylactic reaction?

Which of the following is consistent with bacterial contamination reactions?

Changes that occur to RBCs upon storage include an increase in

What is meant by the term iatrogenic?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

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